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Original research article
Contraception 97 (2018) 439–444
https://doi.org/10.1016/j.contraception.2018.01.003
0010-7824/© 2018 The Authors. Published by Elsevier Inc.
PLoS Medicine Vol. 6 no. 10 (2009) e1000165
Health Services Insights Volume 10: 1–7
The Global Burden of Disease Study (GBD) is the most comprehensive worldwide observational epidemiological study to date. It describes mortality and morbidity from major diseases, injuries and risk factors to health at global, national and regional levels. Examining trends from 1990 to the present a
...
nd making comparisons across populations enables understanding of the changing health challenges facing people across the world in the 21st century.
Accessed July 4, 2019
more
This paper looks at the increasing use of 'new psychoactive substances', a term which is defined differently by different people, but which is here defined as 'narcotic drugs or psychotropic substances made available or used from the early to mid-2000s for their psychoactive properties'
Series: Ser
...
ies|Drug Use| Volume 394, ISSUE 10209, P1668-1684, November 02, 2019
more
A Systematic Review and Meta-analysis
Clinical Infectious Diseases® 2016;62(12):1586–94
Lancet Glob Health 2019 Published Online January 24, 2019 http://dx.doi.org/10.1016/S2214-109X(18)30479-0
The health-care system collapse underway in Venezuela is a cause of utmost concern for its people and, increasingly, for the wider region. Declines in provision of basic services, such as
...
childhood immunisation, malaria control, water, sanitation, and nutritional support, have led to increasing morbidity and mortality rates from an array of preventable diseases, including malaria, measles, and diphtheria. Secondary and tertiary care have also been greatly affected, due to declining investment, out-migration of providers, and spiralling hyperinflation that has driven the country and its people into poverty.1 As is so often, and so tragically, the case, the most affected populations have been the most vulnerable: infants and children, their mothers, the poor (now the great majority of the populations), and indigenous people
more
Open AccessPublished:March 28, 2019DOI:https://doi.org/10.1016/S1473-3099(18)30730-8
The Lancet Infectious Diseases
Les programmes de planification familiale sont une solution gagnant-gagnant ; le bien-être de chaque femme et des enfants est amélioré, et l'économie nationale et l'environnement en tirentles bénéfices
BMJ Global Health2019;4:e001504. doi:10.1136/bmjgh-2019-00150
Bull World Health Organ 2016;94:554–556 | doi: http://dx.doi.org/10.2471/BLT.15.162610
After 100 years of chemotherapy with impractical and toxic drugs, an oral cure for human African trypanosomiasis (HAT) is available: Fexinidazole. In this case, we review the history of drug discovery for HAT with special emphasis on the discovery, pre-clinical development, and operational challenge
...
s of the clinical trials of fexinidazole. The screening of the Drugs for Neglected Diseases initiative (DNDi) HAT-library by the Swiss TPH had singled out fexinidazole, originally developed by Hoechst (now Sanofi), as the most promising of a series of over 800 nitroimidazoles and related molecules. In cell culture, fexinidazole has an IC50 of around 1 µM against Trypanosoma brucei and is more than 100-fold less toxic to mammalian cells. In the mouse model, fexinidazole cures both the first, haemolymphatic, and the second, meningoencephalitic stage of the infection, the latter at 100 mg/kg twice daily for 5 days. In patients, the clinical trials managed by DNDi and supported by Swiss TPH mainly conducted in the Democratic Republic of the Congo demonstrated that oral fexinidazole is safe and effective for use against first- and early second-stage sleeping sickness. Based on the positive opinion issued by the European Medicines Agency in 2018, the WHO has released new interim guidelines for the treatment of HAT including fexinidazole as the new therapy for first-stage and non-severe second-stage sleeping sickness caused by Trypanosoma brucei gambiense (gHAT). This greatly facilitates the diagnosis and treatment algorithm for gHAT, increasing the attainable coverage and paving the way towards the envisaged goal of zero transmission by 2030.
more
Lancet 2013; 381: 1405–16
Series: Childhood Pneumonia and Diarrhoea no.1
Public health Panoram, Vol.2 Issue 1 March 2016
BMC Public Health (2018) 18:668 https://doi.org/10.1186/s12889-018-5594-3
Lancet. 2018 Dec 19. pii: S0140-6736(18)31647-7. doi: 10.1016/S0140-6736(18)31647-7. [Epub ahead of print]
Rund drei Viertel der in Deutschland lebenden Flüchtlinge aus Syrien, dem Irak und Afghanistan sind nach Gewalterlebnissen traumatisiert.
Neue Empfehlungen für die Umgebungsuntersuchungen bei Tuberkulose
Diel, R., G. Loytved, A.Nienhaus, et al.
Deutsches Zentralkomitee zur Bekämpfung der Tuberkulose
(2011)
C2
DOI http://dx.doi.org/ 10.1055/s-0030-1256439 Online-Publikation: 10. 5. 2011 Pneumologie 2011; 65: 359–378
La crisis del sistema de salud colombiano: una aproximación desde la legitimidad y la regulación
recommended
Suárez-Rozo LF, Puerto-García S, Rodríguez-Moreno LM, Ramírez-Moreno
Rev. Gerenc. Polit. Salud, Bogotá, Colombia
(2017)
C1
El objetivo fue determinar cuáles son las percepciones de distintos actores del sistema de salud
colombiano sobre los problemas del sistema que están detrás de la crisis. Se realizó un estudio
cualitativo a partir de entrevistas semiestructuradas y en profundidad con cuarenta agentes del
sect
...
or salud, en Bogotá, Cali, Ibagué, Espinal y Calima-Darién. Los resultados mostraron que la
corrupción, el incumplimiento de normas y los conflictos entre los intereses de diversos actores
del sistema debilitan la legitimidad de este último, atomizan la cooperación y cohesión de los
actores y fortalecen el interés particular.
more