Leishmaniasis is a spectrum of disease caused by the infection of protozoan parasite Leishmania mainly affecting the antigen presenting cell of the host. The disease is although considered as neglected tropical disease still it is not completely eradicated. Majority of the issues related to the ther...apeutic approach is due to increased cytotoxicity of the drugs, less effectiveness, high cost and occurrence of drug resistance. Therefore, recent advancement in the field of parasitology has taken into consideration of the specific arms of immunity which can be triggered with the help of natural products, synthetic molecules or parasite specific ligands which helps in the restoration of host protective immunity and recovery from the infection. Therefore, in this review, we have highlighted the recent advancement in the field of Leishmania research taken into consideration of the therapeutic perspective. We have shown that apart from therapeutic potential of the available drugs and vaccination approach, the immune-therapy are emerging as the modern regime of treatment where the effectiveness of the therapy is significantly increased and making it safer and promising.
more
Little progress has been made since the 1960s and 1970s to widen the therapeutic arsenal against Trypanosoma cruzi, the causative pathogen of Chagas disease, which remains a frustrating and perplexing infectious disease. This chapter focuses on the strategic and operational challenges in the clinica...l drug development of a novel antitrypanosomal agent for Chagas disease. The various elements that contribute to a robust assessment of treatment effect including dose selection, choice of patient population, trial methodology, endpoint measures, and regulatory perspectives are discussed. The learnings herein should serve as resource to help researchers and other stakeholders optimize their clinical development plans and speed delivery of new medicines to patients with Chagas disease.
more
To meet the need for laboratory diagnosis to be integrated in community care, the new 2022 Update describes point-of-care tests that can be performed both in district laboratories and peripheral healthcare facilities by non-specialist staff. Also included are recently developed self-tests.
23 March 2021
The meeting addressed the last key area, that is, determining the best method or combination of diagnostic methods for a control programme for S. stercoralis infections in humans.
Dr Montresor’s presentation highlighted that while there is currently no “gold standard” for the... diagnosis of S. stercoralis, there is a felt urgency to optimize diagnostic regimens that are currently available, and in the context of population-based testing (as opposed to individual focused diagnostics in clinical settings).
In other words, the diagnostic test(s) should have good accuracy, but we should remember that in public health we do not aim at individual diagnosis: rather, we need a tool that should help to estimate the prevalence in a population.
more
Estas Pranchas para o diagnóstico microscópico da malária servem como guia para laboratoristas e técnicos de campo responsáveis por diagnóstico microscópico da malária pelo método de Giemsa. Também devem ser úteis para professores e alunos de disciplinas correlatas. As pranchas mostram fo...tomicrografias coloridas de lâminas de sangue (esfregaços e gotas espessas), coradas, e texto explicativo sobre as quatro espécies de parasitos causadores da malária humana e sua morfologia. São fornecidas descrições completas de cada espécie, bem como instruções sobre o preparo de lâminas e esfregaços, o uso de soluções tampão, o método de coloração Giemsa, o exame das lâminas e procedimentos para estimar a densidade parasitária. Nada será adicionado sobre knowlesi e simium? Acho importante até para que as pessoas saibam com o que se parecem. Também são descritos outros elementos celulares observados no sangue, bem como vários contaminantes comuns que podem ser confundidos com parasitos da malária.
more
Este manual (Parte I dos módulos de capacitação em Bases do diagnóstico microscópico da malária) ajudará os participantes durante seu treinamento em diagnóstico microscópico da malária humana. O manual foi concebido como base para um treinamento formal de quatro a cinco semanas de duraçã...o e destina-se a alunos com conhecimentos rudimentares de ciência. Ao concluir a capacitação, o aluno será responsável pelo diagnóstico de malária com lâminas de sangue de casos suspeitos na sua comunidade. Desse modo, decisões importantes referentes ao tratamento dependem da sua competência em garantir o diagnóstico de malária sem supervisão.
more
For the purposes of presenting the Guide as an e-course it has been divided into five parts. Each part of the course takes 30 to 45 minutes and must be completed in order. You can save and exit at any point throughout the course.
The five quiz sections presented at the end of each part of the cours...e are not part of the Basic Malaria Microscopy Learner’s Guide. They have been created by the Global Health Network to help you test your knowledge of the course and to gain a certificate to demonstrate that you have completed it
more
This WHO information note provides an updated list of recommended criteria for selecting RDTs for malaria, and highlights the performance of RDTs evaluated by the WHO malaria RDT product testing programme. It also provides an overview of additional considerations in the procurement of rapid tests.
The purpose of this manual is to train health workers to use G6PD rapid diagnostic tests (RDTs) safely and effectively, so as to inform appropriate decision making for P. vivax radical cure. This manual should be used with the accompanying job aid. The job aid is a set of step-by-step instructions a...bout how to use a G6PD RDT. It contains both words and pictures.
more