Any individual that meets the suspected case definition of monkeypox should be offered testing in appropriately equipped laboratories by staff trained in the relevant technical and safety procedures. Confirmation of monkeypox virus infection is based on nucleic acid amplification testing (NAAT), usi...ng real-time or conventional polymerase chain reaction (PCR), for detection of unique sequences of viral DNA. PCR can be used alone, or in combination with sequencing. The recommended specimen type for laboratory confirmation of monkeypox is skin lesion material, including swabs of lesion surface and/or exudate, roofs from more than one lesion, or lesion crusts.
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Monkeypox: Cumulative confirmed cases, by date of confirmation
Cases of human monkeypox are rarely seen outside of west and central Africa. There are few data regarding viral kinetics or the duration of viral shedding and no licensed treatments. Two oral drugs, brincidofovir and tecovirimat, have been approved for treatment of smallpox and have demonstrated eff...icacy against monkeypox in animals. Our aim was to describe the longitudinal clinical course of monkeypox in a high-income setting, coupled with viral dynamics, and any adverse events related to novel antiviral therapies.
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Therapiehinweise des STAKOB unter Mitwirkung von BfArM, DGI, DGPI, DTG, PEI und Pocken Konsiliarlabor RKI - ZBS 1
Where are the outbreaks? What is monkeypox? Recongnizing monkeypox and more. An update on the monkeypox outbreak including protection, diagnosis, treatment.
Nach dem derzeitigen Informationsstand sind aktuell humane Infektionen durch das Affenpockenvirus (monkeypox virus, MPX) in einigen Regionen der Welt einschließlich mehreren europäischen Ländern aufgetreten. Die Daten belegen eine Mensch-zu-Mensch-Übertragung unter bestimmten Bedingungen. Die Ü...bertragung von MPX von Mensch zu Mensch erfolgt in der Regel durch engen Haut- bzw. Schleimhautkontakt mit infektiösem Material aus den Hautläsionen einer infizierten Person, sowie – seltener – durch respiratorische Tröpfchen/Sekrete z.B. bei längerem Kontakt von Angesicht zu Angesicht oder durch kontaminierte Gegenstände und Oberflächen. Bei diesem Erreger ist besonders zu beachten, dass Partikel des Affenpockenvirus eingebettet in Sekreten bzw. getrocknet an Hautschuppen bzw. Schorfpartikeln für längere Zeiträume infektiös sein können, was eine sorgfältige und umfassende Reinigung und Desinfektion der Patientenumgebung bzw. der Oberflächen notwendig macht.
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The goal of the global outbreak response for monkeypox is to stop human-to-human transmission of monkeypox, with a priority focus on communities at high risk of exposure which may differ according to context, and to effectively use strong public health measures to prevent onward spread of the diseas...e. Judicious use of vaccines can support this response. This interim guidance, developed with the advice and support of the Strategic Advisory Group of Experts (SAGE) Working Group on smallpox and monkeypox vaccines, provides the first WHO recommendations on vaccines and immunization for monkeypox. Key points follow.
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Interim rapid response guidance, 10 June 2022.
It includes considerations for certain populations such as patients with mild disease with considerations for community care, patients with moderate to severe disease, sexually active persons, pregnant or breastfeeding women, children and young persons.... The guidance also addresses considerations for clinical management such as the use of therapeutics, nutritional support, mental health services, and post-infection follow-up.
The document provides guidance for clinicians, health facility managers, health workers and infection prevention and control practitioners including but not limited to those working in primary care clinics, sexual health clinics, emergency departments, infectious diseases clinics, genitourinary clinics, dermatology clinics, maternity services, paediatrics, obstetrics and gynaecology and acute care facilities that provide care for patients with suspected or confirmed monkeypox
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MEDBOX Issue Brief no.22, updated August 9, 2022
Interim rapid response guidance, 10 June 2022.
It includes considerations for certain populations such as patients with mild disease with considerations for community care, patients with moderate to severe disease, sexually active persons, pregnant or breastfeeding women, children and young persons.... The guidance also addresses considerations for clinical management such as the use of therapeutics, nutritional support, mental health services, and post-infection follow-up.
The document provides guidance for clinicians, health facility managers, health workers and infection prevention and control practitioners including but not limited to those working in primary care clinics, sexual health clinics, emergency departments, infectious diseases clinics, genitourinary clinics, dermatology clinics, maternity services, paediatrics, obstetrics and gynaecology and acute care facilities that provide care for patients with suspected or confirmed monkeypox
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