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WHO Sciene in 5 #13 - COVID-19 - Vaccine trials

World Health Organization WHO (2021) C_WHO
Learn what scientists look for in the different phases of a clinical trial for a vaccine. What does it mean when a vaccine ... is halted due to an adverse event? WHO’s Dr Kate O’Brien explains in Science in 5 this week more
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GUIDELINES FOR CONDUCTING CLINICAL TRIALS OF MEDICINES, FOOD SUPPLEMENTS, VACCINES AND MEDICAL DEVICES IN GHANA

Food and Drugs Authority (FDA), Ghana (2013) C1
Document No. : FDA/SMC/CTD/GL-CCT/2013/01
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Efficacy and effectiveness of an rVSV-vectored vaccine expressing Ebola surface glycoprotein: interim results from the Guinea ring vaccination cluster-randomised trial

Ana Maria Henao-Restrepo, Ira M Longini, Matthias Egger, et al. (2015)
the Lancet : Published Online July 31, 2015 http://dx.doi.org/10.1016/S0140-6736(15)61117-5
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Emergency Use Designation of COVID-19 candidate vaccines: Ethical considerations for current and future COVID-19 placebo-controlled vaccine trials and trial unblinding

World Health Organization WHO (2020) C_WHO
The conduct of COVID-19 vaccine trials in the context of a candidate vaccine being issued with Emergency Use Designation raises challenging ethical... more
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Africa CDC Consortium for COVID-19 Vaccine Clinical Trials (CONCVACT)

African Union; Africa CDC Centres for Disease Control and Prevention (2020) C1
August 2020, The Africa Joint Continental Strategy for COVID-19 is underpinned by the need to limit transmission, prevent deaths and reduce associated harms. Participation by African nations in clinical trials is an essential step to ensure that suf... more
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Guidelines for Cunducting Clinical Trials of Medicines, Food Supplements, Vaccines, and Medical Devices in Sierra Leone

Pharmacy Board Sierra Leone (2014) C1
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Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: final results from the Guinea ring vaccination, open-label, cluster-randomised trial (Ebola Ça Suffit!)

Henao-Restrepo, A.M.; et al. (2016)
The Lancet. Published Online December 22, 2016 http://dx.doi.org/10.1016/S0140-6736(16)32621-6. Open Access
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Sierra Leone: Guidelines for Conducting Clinical Trials of Medicinal Products and Vaccines

Pharmacy Board Sierra Leone (2014) C1
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Effect of a single inactivated poliovirus vaccine dose on intestinal immunity against poliovirus in children previously given oral vaccine: an open-label, randomised controlled trial

Jacob John, et al. The Lancet (2014)
The Lancet, Early Online Publication, 11 July 2014 doi:10.1016/S0140-6736(14)60934-X *Free registration is required to view this article
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Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia

Logunov, D.Y, et al. (2021) C1
Published:February 02, 2021DOI:https://doi.org/10.1016/S0140-6736(21)00234-8
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Global roadmap for research and development of tuberculosis vaccines

European & Developing Countries Clinical Trials Partnership EDCTTP; Amterdam Institute for Global health & Development aighd (2021) C1
The roadmap describes the actions needed to achieve the three development goals for TB vaccines set by the WHO: 1. A safe, effective and affordable TB vaccine for adolescents and adults. 2. An ... more
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Ebola research and development landscape of clinical candidates and trials

World Health Organization (WHO) (2015) C_WHO
The report presents current information (updated to September 2015) on candidate vaccines, therapies and medical devices for Ebola and gives an overview of completed and on-going trials.
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COVID-19 vaccine tracker and landscape
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World Health Organization WHO (2022) C_WHO
The COVID-19 vaccine tracker and landscape compiles detailed information of each COVID-19 vaccine candidate in development by closely monitoring their progress through the pipeline. The COVID-19 ... more
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Manufacturing, safety and quality control of vaccines

World Health Organization WHO (2020) C_WHO
This document is part three in a series of explainers on vaccine development and distribution. Part one focused on how vaccines work to protect our bodies from disease-carrying germs. Part two focu... more
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How are vaccines developed?

World Health Organization WHO (2021) C_WHO
This article is part two in a series of explainers on vaccine development and distribution. Part one focused on how vaccines work to protect our bodies from disease-carrying germs. This article foc... more
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How does the Pfizer COVID vaccine work?

BioDigital (2020) CC
Exciting news this week with @Pfizer reporting their mRNA vaccine is 90% effective, based on their Phase III clinical trial data. Dr. Tom looks inside the virus to break down how mRNA ... work, and whether news this promising means we can finally relax. more
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The different types of COVID-19 vaccines

World Health Organization WHO (2020) C_WHO
This article is part four in a series of explainers on vaccine development and distribution. Part one focused on how vaccines work to protect our bodies from disease-carrying germs. Part two focus... more
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ChAdOx1-S [recombinant], COVID-19 vaccine

World Health Organization WHO (2021) C_WHO
Manufacturers: SK Bioscience Co. Ltd. [COVID-19 Vaccine (ChAdOx1-S [recombinant])] Serum Institute of India Pvt. Ltd. [COVISHIELD™, ChAdOx1 nCoV-19 Corona Virus Vaccine (Recombinant)] ... more
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AstraZeneca ChAdOx1-S/nCoV-19 [recombinant], COVID-19 vaccine

World Health Organization WHO (2021) C_WHO
10 May 2021. Manufactureres: SK Bioscience Co. Ltd. [COVID-19 Vaccine (ChAdOx1-S [recombinant])] Serum Institute of India Pvt. Ltd. [COVISHIELD™, ChAdOx1 nCoV-19 Corona Virus Vaccine (R... more
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How does Moderna's Coronavirus vaccine work?

The Telegraph (2020) CC
Early data from US biotech Moderna has revealed that its Covid-19 vaccine candidate is 94.5 per cent effective, raising hopes that a range of immunisations will be available to help end the pandemic. The interim analysis of the ..., currently known as mRNA-1273, comes after 95 trial participants contracted Covid-19, including just five who were given the coronavirus jab. more