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Preventive chemotherapy to control soil-transmitted helminth infections in at-risk population groups
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A. Montresor World Health Organisation (WHO) (2017) C_WHO

Treating children infected with intestinal worms is one of the simplest and most cost–effective ways to improve their health. The recommendations are intended for a wide audience, including policy-makers and their expert advisers as well as technical and programme staff at government institution... more

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Preventive chemotherapy in human helminthiasis : coordinated use of anthelminthic drugs in control

World Health Organization (2006) C_WHO

Coordinated Use of Anthelminthic Drugs in Control Interventions: a Manual for Health Professionals and Programme Managers

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Helminth control in school age children: a guide for managers of control programmes

WHO (2011)

2nd ed.

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Stunting as a Risk Factor of Soil-Transmitted Helminthiasis in Children: A Literature Review

Fauziah, N.; Ar-Rizqi, M.A.; Hana, S. et al. Interdisciplinary Perspectives on Infectious Diseases (2022) CC

As a high-burden neglected tropical disease, soil-transmitted helminth (STH) infections remain a major problem in the world, especially among children under five years of age. Since young children are at high risk of being infected, STH infection can have a long-term negative impact on their life, i... more

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Crossing the billion: Lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminthiases and trachoma. Preventive chemotherapy for neglected tropical diseases

World Health Organization (WHO) (2017) C_WHO

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HELP - Helminthiasis factsheet

HELP - Helminth Elimination Platform (2023) C2

Accessed on 22.04.2023 To target helminth elimination, a new consortium of research institutes, universities, not-for-profit organizations, and pharmaceutical companies have joined forces and expertise to establish a research and development pipeline for the development of anthelminthics targeti... more

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WASH and the Neglected Tropical Diseases

Ogden, S., Gallo, K., Davis, S., et al Sightsavers, Department for International Development, The International Trachoma Initiative , et al. (2013) C2

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WASH and the Neglected Tropical Diseases (MOZAMBIQUE)

Ogden Stephanie et al (2013) C1

This manual is intended to enable WASH practitioners who work in Mozambique to contribute to the reduction of WASH-preventable NTDs.

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Diagnostic target product profile for monitoring and evaluation of soil-transmitted helminth control programmes

World Health Organization WHO (2021) C_WHO

Soil-transmitted helminths are a group of intestinal worms that include Ascaris lumbricoides (giant roundworm), Trichuris trichiura (whipworm), and Ancylostoma spp. (A. duodenale, A. ceylanicum) and Necator americanus (hookworms). Despite the clear biological differences among the different species,... more

Guidelines for School-based Deworming Programs

School Health Integrated Programming (SHIP) (2016) C1

Information for policy-makers and planners on conducting deworming as part of an integrated school health program

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Plan Directeur National de Lutte Integrée Contre les Maladies Tropicales Négligées

Ministere de la Santé, Direction Nationale de la Santé Publique , Programme National de Lutte contre les Maladies Transmissibles, Bénin (2017) C2

L’OMS a ciblé 17 maladies comme des Maladies Tropicales Négligées. Ces maladies sont très différentes les unes des autres, mais elles ont comme point commun de toucher principalement les populations les plus pauvres. Elles maintiennent dans la pauvreté les populations ayant initialement un n... more

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Burden of disease from inadequate water, sanitation and hygiene for selected adverse health outcomes: An updated analysis with a focus on low- and middle-income countries

Prüss-Ustün A., Wolf J., Bartram J., et al. (2019) CC

Int J Hyg Environ Health. 2019 Jun; 222(5): 765–777. doi: 10.1016/j.ijheh.2019.05.004; To develop updated estimates in response to new exposure and exposure-response data of the burden of diarrhoea, respiratory infections, malnutrition, schistosomiasis, malaria, soil-transmitted helminth infec... more

Safety in administering medicines for neglected tropical diseases

World Health Organization WHO (2021) C_WHO

This manual summarizes key issues related to the safety of NTD medicines and their administration, with a focus on essential medicines used in mass drug administration (MDA), also called preventive chemotherapy. It can be used as a standalone reference manual, but is intended to be used in conjuncti... more

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Helminths Filarisasis

RWJF Microbiology, Immunology & Infectious Diseases (2016) C2

This video is part of a comprehensive medical school microbiology, immunology & infectious diseases course. Your comments on videos will be key as we iterate content.

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Soil-Transmitted Helminthiasis in Children from a Rural Community Taking Part in a Periodic Deworming Program in the Peruvian Amazon

Errea, R.; Vasquez-Rios, G.; Calderon, M.; et al. The American Jornal of Tropical Medicine and Hygiene (2019) CC

Infections by the soil-transmitted helminths (STH), including Ascaris lumbricoides, Trichuris trichiura, Ancylostoma duodenale/Necator americanus (hookworms), and Strongyloides stercoralis, disproportionately affect children around the world. Because of their transmission associated with poor sanita... more

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Assessing the feasibility of interrupting the transmission of soil-transmitted helminths through mass drug administration: The DeWorm3 cluster randomized trial protocol

Ásbjörnsdóttir K.H., Ajjampur S.S.R., Anderson R.M. et al (2018) C2

Soil-transmitted helminths (STH) affect 1.45 billion people worldwide, and high intensity infections are associated with anemia, undernutrition and impaired cognition, particularly among children. Mathematical models suggest it may be possible to interrupt the transmission of STH in a community by e... more

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CDC - Soil-Transmitted Helminths

Centers for Disease Control and Prevention CDC (2023) C2

Website last accessed on 24.03.2023 Education and information about Soil-Transmitted Helminths including Human Hookworm, Roundworm and Whipworm.

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Current epidemiological evidence for predisposition to high or low intensity human helminth infection: a systematic review

Wright J.E., Werkman M., Dunn J.C. et al Parasites and Vectors (2018) C2

Background: The human helminth infections include ascariasis, trichuriasis, hookworm infections, schistosomiasis, lymphatic filariasis (LF) and onchocerciasis. It is estimated that almost 2 billion people worldwide are infected with helminths. Whilst the WHO treatment guidelines for helminth infecti...ons are mostly aimed at controlling morbidity, there has been a recent shift with some countries moving towards goals of disease elimination through mass drug administration, especially for LF and onchocerciasis. However, as prevalence is driven lower, treating entire populations may no longer be the most efficient or cost-effective strategy. Instead, it may be beneficial to identify individuals or demographic groups who are persistently infected, often termed as being “predisposed” to infection, and target treatment at them. Methods: The authors searched Embase, MEDLINE, Global Health, and Web of Science for all English language, humanbased papers investigating predisposition to helminth infections published up to October 31st, 2017. The varying definitions used to describe predisposition, and the statistical tests used to determine its presence, are summarised. Evidence for predisposition is presented, stratified by helminth species, and risk factors for predisposition to infection are identified and discussed. Results: In total, 43 papers were identified, summarising results from 34 different studies in 23 countries. Consistent evidence of predisposition to infection with certain species of human helminth was identified. Children were regularly found to experience greater predisposition to Ascaris lumbricoides, Schistosoma mansoni and S. haematobium than adults. Females were found to be more predisposed to A. lumbricoides infection than were males. Household clustering of infection was identified for A. lumbricoides, T. trichiura and S. japonicum. Ascaris lumbricoides and T. trichiura also showed evidence of familial predisposition. Whilst strong evidence for predisposition to hookworm infection was identified, findings with regards to which groups were affected were considerably more varied than for other helminth species. Conclusion: This review has found consistent evidence of predisposition to heavy (and light) infection for certain human helminth species. However, further research is needed to identify reasons for the reported differences between demographic groups. Molecular epidemiological methods associated with whole genome sequencing to determine ‘who infects whom’ may shed more light on the factors generating predisposition. more

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Deadly Worms!!! – A look at Soil Transmitted Helminths

Let's learn abut bugs (2023) C2

Website last accessed on 31.03.2023 Youtube Video (Explainity)

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Integrated community-based intervention for urinary schistosomiasis and soil-transmitted helminthiasis in children from Caxito, Angola

Lemosa, M.; Fançonya, C.; Moura, S. et al The royal society of tropical medicine and hygiene (2020) C2

Schistosomiasis and soil-transmitted helminths (STH) infections are major public health problems. We aimed to study the 6-mo impact of mass drug administration with praziquantel and albendazole on urinary schistosomiasis and STH.We examined children (aged 2–15 y) from one hamlet, who provided urin... more

Preventive chemotherapy to control soil-transmitted helminth infections in at-risk population groups recommended

Preventive chemotherapy to control soil-transmitted helminth infections in at-risk population groups
recommended