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Helminths Filarisasis

RWJF Microbiology, Immunology & Infectious Diseases (2016) C2

This video is part of a comprehensive medical school microbiology, immunology & infectious diseases course. Your comments on videos will be key as we iterate content.

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Helminth control in school age children: a guide for managers of control programmes

WHO (2011)

2nd ed.

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Preventive chemotherapy in human helminthiasis : coordinated use of anthelminthic drugs in control

World Health Organization (2006) C_WHO

Coordinated Use of Anthelminthic Drugs in Control Interventions: a Manual for Health Professionals and Programme Managers

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Preventive chemotherapy to control soil-transmitted helminth infections in at-risk population groups
recommended

A. Montresor World Health Organisation (WHO) (2017) C_WHO

Treating children infected with intestinal worms is one of the simplest and most cost–effective ways to improve their health. The recommendations are intended for a wide audience, including policy-makers and their expert advisers as well as technical and programme staff at government institution... more

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Diagnostic target product profile for monitoring and evaluation of soil-transmitted helminth control programmes

World Health Organization WHO (2021) C_WHO

Soil-transmitted helminths are a group of intestinal worms that include Ascaris lumbricoides (giant roundworm), Trichuris trichiura (whipworm), and Ancylostoma spp. (A. duodenale, A. ceylanicum) and Necator americanus (hookworms). Despite the clear biological differences among the different species,... more

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HELP - Helminthiasis factsheet

HELP - Helminth Elimination Platform (2023) C2

Accessed on 22.04.2023 To target helminth elimination, a new consortium of research institutes, universities, not-for-profit organizations, and pharmaceutical companies have joined forces and expertise to establish a research and development pipeline for the development of anthelminthics targeti... more

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Soil-Transmitted Helminthiasis in Children from a Rural Community Taking Part in a Periodic Deworming Program in the Peruvian Amazon

Errea, R.; Vasquez-Rios, G.; Calderon, M.; et al. The American Jornal of Tropical Medicine and Hygiene (2019) CC

Infections by the soil-transmitted helminths (STH), including Ascaris lumbricoides, Trichuris trichiura, Ancylostoma duodenale/Necator americanus (hookworms), and Strongyloides stercoralis, disproportionately affect children around the world. Because of their transmission associated with poor sanita... more

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Assessing the feasibility of interrupting the transmission of soil-transmitted helminths through mass drug administration: The DeWorm3 cluster randomized trial protocol

Ásbjörnsdóttir K.H., Ajjampur S.S.R., Anderson R.M. et al (2018) C2

Soil-transmitted helminths (STH) affect 1.45 billion people worldwide, and high intensity infections are associated with anemia, undernutrition and impaired cognition, particularly among children. Mathematical models suggest it may be possible to interrupt the transmission of STH in a community by e... more

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CDC - Soil-Transmitted Helminths

Centers for Disease Control and Prevention CDC (2023) C2

Website last accessed on 24.03.2023 Education and information about Soil-Transmitted Helminths including Human Hookworm, Roundworm and Whipworm.

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Current epidemiological evidence for predisposition to high or low intensity human helminth infection: a systematic review

Wright J.E., Werkman M., Dunn J.C. et al Parasites and Vectors (2018) C2

Background: The human helminth infections include ascariasis, trichuriasis, hookworm infections, schistosomiasis, lymphatic filariasis (LF) and onchocerciasis. It is estimated that almost 2 billion people worldwide are infected with helminths. Whilst the WHO treatment guidelines for helminth infecti...ons are mostly aimed at controlling morbidity, there has been a recent shift with some countries moving towards goals of disease elimination through mass drug administration, especially for LF and onchocerciasis. However, as prevalence is driven lower, treating entire populations may no longer be the most efficient or cost-effective strategy. Instead, it may be beneficial to identify individuals or demographic groups who are persistently infected, often termed as being “predisposed” to infection, and target treatment at them. Methods: The authors searched Embase, MEDLINE, Global Health, and Web of Science for all English language, humanbased papers investigating predisposition to helminth infections published up to October 31st, 2017. The varying definitions used to describe predisposition, and the statistical tests used to determine its presence, are summarised. Evidence for predisposition is presented, stratified by helminth species, and risk factors for predisposition to infection are identified and discussed. Results: In total, 43 papers were identified, summarising results from 34 different studies in 23 countries. Consistent evidence of predisposition to infection with certain species of human helminth was identified. Children were regularly found to experience greater predisposition to Ascaris lumbricoides, Schistosoma mansoni and S. haematobium than adults. Females were found to be more predisposed to A. lumbricoides infection than were males. Household clustering of infection was identified for A. lumbricoides, T. trichiura and S. japonicum. Ascaris lumbricoides and T. trichiura also showed evidence of familial predisposition. Whilst strong evidence for predisposition to hookworm infection was identified, findings with regards to which groups were affected were considerably more varied than for other helminth species. Conclusion: This review has found consistent evidence of predisposition to heavy (and light) infection for certain human helminth species. However, further research is needed to identify reasons for the reported differences between demographic groups. Molecular epidemiological methods associated with whole genome sequencing to determine ‘who infects whom’ may shed more light on the factors generating predisposition. more

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Deadly Worms!!! – A look at Soil Transmitted Helminths

Let's learn abut bugs (2023) C2

Website last accessed on 31.03.2023 Youtube Video (Explainity)

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Integrated community-based intervention for urinary schistosomiasis and soil-transmitted helminthiasis in children from Caxito, Angola

Lemosa, M.; Fançonya, C.; Moura, S. et al The royal society of tropical medicine and hygiene (2020) C2

Schistosomiasis and soil-transmitted helminths (STH) infections are major public health problems. We aimed to study the 6-mo impact of mass drug administration with praziquantel and albendazole on urinary schistosomiasis and STH.We examined children (aged 2–15 y) from one hamlet, who provided urin... more

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Elimination of soil-transmitted helminthiasis infection in Bangladesh: Knowledge, attitudes, and practices regarding mass drug administration

Tilak C.N., Retna S.P., Mohammad S.A. et al (2018) C2

Background: Despite several cycles of Mass Drug Administration (MDA), however, the prevalence of Soil-transmitted helminthiasis (STH) remains high in Bangladesh. A clear understanding of local knowledge, attitudes, and practices (KAP) related to the acceptance and utilization of MDA is critical for ... more

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Estimating the population at risk with soil transmitted helminthiasis and annual drug requirements for preventive chemotherapy in Ogun State, Nigeria

Mogaji H.O., Johnson O.O. , Adigun A.B. et al Nature (2022) C2

Soil transmitted helminth (STH) infections are among the most common human infections worldwide with over 1 billion people affected. Many estimates of STH infection are often based on school-aged children (SAC). This study produced predictive risk-maps of STH on a more finite scale, estimated the nu... more

Soil-transmitted helminthiases

World Health Organization WHO (2020) C_WHO

oil-transmitted helminth (STH) infections are among the most common infections worldwide and affect the poorest and most deprived communities. They are transmitted by eggs present in human faeces which in turn contaminate soil in areas where sanitation is poor. The main species that infect peopl... more

Schistosomiasis and soil-transmitted helminthiases: treating millions of people, despite the pandemic

World Health Organization WHO (2021) CC

Despite pandemic-related disruptions, a total of 76.9 million people received treatment for schistosomiasis in 2020, representing a global coverage of 31.9%, compared with 105 million treated in 2019 (coverage of 44.8%). The latest data published by the World Health Organization (WHO) show that 2... more

Soil-transmitted helminth infections - Key Facts

World Health Organization WHO (2023) CC

Soil-transmitted helminth (STH) infections are among the most common infections worldwide with an estimated 1.5 billion infected people or 24% of the world’s population. These infections affect the poorest and most deprived communities with poor access to clean water, sanitation and hygiene in tro... more

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Soil-transmitted helminthiases (STH)

World Health Organization WHO (2022) C_WHO

Soil-transmitted helminth (STH) infections are among the most common infections worldwide and affect the poorest and most deprived communities. They are transmitted by eggs present in human faeces which in turn contaminate soil in areas where sanitation is poor.

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Schistosomiasis and soil-transmitted helminthiases: progress report, 2022

World Health Organization WHO (2023) C_WHO

Human schistosomiasis is caused mainly by 3 schistosome species: Schistosoma haematobium, S. mansoni and S. japonicum. S. guineensis, S. intercalatum and S. mekongi have a highly localized distribution in Central Africa and along the Mekong River in South-East Asia, respectively. Soil-transmitted h... more

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Diagnostic Techniques for Soil-Transmitted Helminths – Recent Advances

Khurana S., Singh S. et al. Dovepress (2021) C2

Diagnostic performance, cost-effectiveness, ease of performance, rapidity and in-field applicability of tests for Soil-transmitted helminth infections.

Preventive chemotherapy to control soil-transmitted helminth infections in at-risk population groups recommended

Preventive chemotherapy to control soil-transmitted helminth infections in at-risk population groups
recommended