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Gambiense human African trypanosomiasis: the bumpy road to elimination

Hasker E, Hope A, Bottieau E. Wolters Kluwer Health, Inc. (2022) C2
Gambiense human African trypanosomiasis is a deadly infectious disease affecting West and Central Africa, South Sudan and Uganda, and transmitted between humans by tsetse flies. The disease has caused several major epidemics, the latest one in the 1990s. Thanks to recent innovations such as rapid di... more
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The Gambia - Effective and humane mental health treatment and care for all

Mental Health Improvements for Nations Development (MIND); Department of Mental Health & Substance Abuse World Health Organization (2019) C_WHO
Republic of The Gambia; Accessed on 31.01.2019
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Gambia: Ebola Virus preparedness Emergency Plan of Action (EPoA) DREF Operation n° MDRGM009

International Federation of Red Cross And Red Crescent Societies (2015)
In February 2014, there was an outbreak of the Ebola Virus Disease (EVD) in Guinea, which has spread to Liberia, Mali, Nigeria, Senegal and Sierra Leone causing untold hardship and hundreds of deaths in these countries. As of 6 March 2015, a total of 24,282 cases, and 9,976 deaths, which were attrib... more
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Tsetse Control and Gambian Sleeping Sickness; Implications for Control Strategy

Tirados, I.; Esterhuizen, J.; Kovacic, V.; Mangwiro, TNC.; Vale, GA et al. PLOS Neglected Tropical Diseases (2015) CC
Sleeping sickness is controlled by case detection and treatment but this often only reaches less than 75% of the population. Vector control is capable of completely interrupting HAT transmission but is not used because of expense. We conducted a full scale field trial of a refined vector control tec... more
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Treatment options for second-stage gambiense human African trypanosomiasis

Eperon, G.; Balasegaram, M.; Potet, J.; Mowbray, C.; Valverde, O.; ois Chappui, F. Informa Healthcare (2014) CC
Treatment of second-stage gambiense human African trypanosomiasis relied on toxicarsenic-based derivatives for over 50 years. The availability and subsequent use of eflornithine,initially in monotherapy and more recently in combination with nifurtimox (NECT), has drasticallyimproved the pro... more
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Fexinidazole for T.b. gambiense (Sleeping Sickness)

Drugs for Neglected Diseases initiative DNDi (2022) C2
DNDi is now striving to make fexinidazole available to the majority of people who have T.b. gambiense sleeping sickness. We are supporting a three-year access and pharmacovigilance study that began in 2020 and have so far carried out in-country training of relevant staff in 250 hospitals and... more
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WHO interim guidelines for the treatment of gambiense human African trypanosomiasis

World Health Organization WHO (2019) C_WHO
This document focuses on the management of patients affected by gambiense HAT and constitutes an update to the WHO therapeutic guidance issued in 2013. The main changes in recommendations concern the criteria and methods for deciding the treatment among the new set of therapeutic options and the pa... more
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Report of the fourth WHO stakeholders meeting on gambiense and rhodesiense human African trypanosomiasis elimination: virtual meeting, 1–3 June 2021

World Health Organization WHO (2021) C_WHO
Since 2000, concerted efforts by national programmes, supported by public–private partnerships, nongovernmental organizations, donors and academia under the auspices and coordination of the World Health Organization (WHO), have produced important achievements in the control of human African trypan... more
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Vector control and the elimination of gambiense human African trypanosomiasis

World Health Organization WHO (2022) C_WHO
The main purpose of the meeting was to review tsetse control tools, activities and their contribution to the elimination of gHAT and the monitoring thereof. Seven endemic countries provided reports on recent and ongoing vector control interventions at the national level (Angola, Cameroon, Côte d’... more
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Target product profile for a gambiense human African trypanosomiasis test to identify individuals to receive widened treatment

World Health Organization WHO (2022) C_WHO
The development of this target product profile (TPP) was led by the WHO Department of Control of Neglected Tropical Diseases (NTD) following standard WHO guidance for TPP development. In order to identify and prioritize diagnostic needs, a WHO NTD Diagnostics Technical Advisory Group (DTAG) was form... more
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Accuracy of Five Algorithms to Diagnose Gambiense Human African Trypanosomiasis
recommended

Francesco Checchi, Francois Chappuis, Unni Karunakara, Gerardo Priotto, Daniel Chandramohan (2011) C1
Plos Neglected Tropical Diaseses, vol. 5 (2011) Issue 7 e1233. Open Access. Please download from the website
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Lignes directrices provisoires de l’OMS pour le traitement de la trypanosomiase humaine africaine à T. b. gambiense

World Health Organization WHO (2019) C_WHO
Les progrès remarquables réalisés dans la lutte contre la forme à T. b. gambiense reposent sur le dépistage et le traitement curatif, une stratégie qui interrompt la transmission en réduisant le réservoir de parasites chez l’être humain. Parfois, cette approche a été combinée avec des... more
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The elimination of human African trypanosomiasis is in sight: Report from the third WHO stakeholders meeting on elimination of gambiense human African trypanosomiasis

Barret, M.P. (2018) CC
In 2012, the World Health Organisation (WHO) set out a roadmap for the control, elimination, or eradication of 17 neglected tropical diseases by 2020. Many were skeptical about the achievability of such goals. Now, still two years away from that end point, good news is emerging for gambiense human A... more
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National Guidelines for the Management of Tuberculosis 2013-2017, 3rd ed.

Republic of the Gambia, Ministry of Health and Social Welfare, National LeprosyTB Control Programme (2012) C1
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AidData's Methodology for Tracking Underreported Financial Flows, Version 1.1.

Strange, A. M.; B. O’Donnell; D. Gamboa et al. AidData at William & Mary (2013) CC
AidData has developed a set of open source data collection methods to track project-level data on suppliers of official finance who do not participate in global reporting systems. This codebook outlines the version 1.1 set of TUFF procedures that have been developed, tested, refined, and implemented... more
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COComportamiento de la tuberculosis y avances en la implementacion del plan estrategico hacia el fin de la tuberculosis en Colombia 2016-2025.

Gómez, F.R.; L. A. M. Osorio, D. I. Cárdenas Gamboa et al. Ministerio de Salud Colombia (2020) CC
La tuberculosis persiste como una grave problemática para la salud pública a nivel internacional y nacional dado que continúa siendo una de las diez primeras causas de morbilidad y mortalidad derivada de enfermedades infectocontagiosas en la población.