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Optimizing Clinical Trial Design to Maximize Evidence Generation in Pediatric HIV

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Solidarity” clinical trial for COVID-19 treatments

World Health Organization WHO (2020) CC
Solidarity” is an international clinical trial to help find an effective treatment for COVID-19, launched by the World Health Organization and partners. The Solidarity Trial will compare four treatment options against standard of care, to assess their relative effectiveness against COVID-19. By... more
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Ebola research and development landscape of clinical candidates and trials

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The report presents current information (updated to September 2015) on candidate vaccines, therapies and medical devices for Ebola and gives an overview of completed and on-going trials.
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Africa CDC Consortium for COVID-19 Vaccine Clinical Trials (CONCVACT)

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August 2020, The Africa Joint Continental Strategy for COVID-19 is underpinned by the need to limit transmission, prevent deaths and reduce associated harms. Participation by African nations in clinical trials is an essential step to ensure that sufficient data is generated on the safety and efficac... more
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Cognitive Training for Schizophrenia in Developing Countries: A Pilot Trial in Brazil (Clinical Study)

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Cognitive deficits in schizophrenia can massively impact functionality and quality of life, furthering the importance of cognitive training. Despite the development of the field in Europe and in the United States, no programmes have been developed and tested in developing countries. Different cultur... more
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Nothing About Us Without RIGHTS—Meaningful Engagement of Children and Youth: From Research Prioritization to Clinical Trials, Implementation Science, and Policy

C. Oliveras; L. Cluver; S. Bernays; A. Armstrong JAIDS Journal of Acquired Immune Deficiency Syndromes; PubMed (2018) C2
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Efficacy and Safety of Pafuramidine versus Pentamidine Maleate for Treatment of First Stage Sleeping Sickness in a Randomized, Comparator-Controlled, International Phase 3 Clinical Trial

Pohlig G, Bernhard SC, Blum J, Burri C, Mpanya A, et al. PLOS Neclected Tropical Diseases (2016) CC
This was a Phase 3, multi-center, randomized, open-label, parallel-group, active control study where 273 male and female patients with first stage Trypanosoma brucei gambiense HAT were treated at six sites: one trypanosomiasis reference center in Angola, one hospital in South Sudan, and four hospita... more
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BCG vaccination induces HIV target cell activation in HIV-exposed infants in a randomized trial

M. A. Gasper, A. C. Hesseling, I. Mohar, et al. JCI insight (2017) C2
Clinical Medicine JCI Insight. 2017;2(7):e91963.
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Clinical Presentation of T.b. rhodesiense Sleeping Sickness in Second Stage Patients from Tanzania and Uganda

Kuepfer, I.; Hhary, EP.; Mpairwe, A.; Edielu, A.; Burri, C.; Blum, JA. PLOS Neglected Tropical Diseases (2011) CC
A wide spectrum of disease severity has been described for Human African Trypanosomiasis (HAT) due to Trypanosoma brucei rhodesiense (T.b. rhodesiense), ranging from chronic disease patterns in southern countries of East Africa to an increase in virulence towards the north. However, only limited d... more
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WHO Sciene in 5 #13 - COVID-19 - Vaccine trials

World Health Organization WHO (2021) C_WHO
Learn what scientists look for in the different phases of a clinical trial for a vaccine. What does it mean when a vaccine trial is halted due to an adverse event? WHO’s Dr Kate O’Brien explains in Science in 5 this week