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DNDi’s long-term goal for sleeping sickness, also known as human African trypanosomiasis (HAT), is to develop and register two new drugs that are effective against both Stage 1 and Stage 2 of the disease and both subspecies of the parasite, T.b. g... more
A wide spectrum of disease severity has been described for Human African Trypanosomiasis (HAT) due to Trypanosoma brucei rhodesiense (T.b. rhodes... more

EMCDDA Monographs

T. Rhodes; D. Hedrich European Monitoring Centre for Drugs and Drug Addiction (2010) C2
Harm reduction: evidence, impacts and challenges -10-
BMJ Global Health2020;5:e002914. doi:10.1136/bmjgh-2020-002914 The evidence produced in mathematical models plays a key role in shaping policy decisions in pandemics. A key question is therefore how well pandemic models relate to their implementation contexts. Drawing on the cases of Ebola and in... more
Human African trypanosomiasis is caused by Trypanosoma brucei gambiense in West and Central Africa and by T. brucei rhodesiense in East Africa; both species are endemic in Uganda. Trypanosoma brucei... more
More countries eliminate human African trypanosomiasis as a public health problem: Benin and Uganda (gambiense form) and Rwanda (rhodesiense form) Human African trypanosomiasis (HAT), or sleeping sickness, transmitted by tsetse flies in sub-Saharan... more
Un comité OMS d’experts sur la trypanosomiase humaine africaine (THA) : lutte et surveillance, s’est réuni à Genève (Suisse), du 22 au 26 avril 2013. Le Dr H. Nakatani, sous-directeur général pour le VIH/SIDA, la tuberculose, le paludisme et les maladies tropicales négligées, a ouvert la... more
Since 2000, concerted efforts by national programmes, supported by public–private partnerships, nongovernmental organizations, donors and academia under the auspices and coordination of the World Health Organization (WHO), have produced important achievements in the control of human African trypan... more
The objectives of the meeting were: 1. To update the current status of the disease transmission, country capacities and plans for tackling the disease. 2. To understand the epidemiology including disease distribution and risk, the models for estimating under-detection, the geographical variati... more
The development of this target product profile (TPP) was led by the WHO Department of Control of Ne- glected Tropical Diseases (NTD) following standard WHO guidance for TPP development. In order to identify and prioritize diagnostic needs, a WHO NTD Diagnostics Technical Advisory Group (DTAG) was... more
Les progrès remarquables réalisés dans la lutte contre la forme à T. b. gambiense reposent sur le dépistage et le traitement curatif, une stratégie qui interrompt la transmission en réduisant le réservoir de parasites chez l’être humain. ... more
Human African trypanosomiasis (HAT), or sleeping sickness, is an endemic disease in 36 sub-Saharan African countries, typically occurring in underdeveloped areas, where health systems face significant difficulties of diverse natures.
Research Article PLOS ONE | https://doi.org/10.1371/journal.pone.0192791 February 15, 2018
Supportive supervision is considered critical to community health worker programme performance, but there is relatively little understanding of how it can be sustainably done at scale. Supportive supervision is a holistic concept that encompasses three key functions: management (ensuring performance... more
EMCDDA Insights - 11 Accessed: 14.03.2019

Biobehavioural Survey Guidelines - For Populations at risk for HIV

A. Abdul-Quader; M. Berry; T. Bingham; J. Burnett; et al. Centers for Diseases Control and Prevention; UNAIDS; World Health Organization; et al. (2017) C_WHO
Global HIV Strategic Information Working Group

Biobehavioural Survey Guidelines

A. Abdul-Quader, M. Berry, T. Bingham; et al. UNAIDS; World Health Organization; fhi360; et al. (2017) C_WHO
Global HIV Strategic Information Working Group For Populations At Risk For HIV
PLOS ONE | www.plosone.org May 2013 | Volume 8 | Issue 5 | e63476
This analysis focused on the chronic form of HAT caused by T. b. gambiense, as it contributes to the majority of disease burden. Information from the literature review, product development landscape, and stakeholder interviews was compiled to: - ... more