Abstract-The paper precisely and briefly explains the socio-economic challenges of persons with disabilities with focus on Ethiopia. The findings of the paper also indicates that, across the countries persons with disabilities <span class="attribute-to-highlight medbox">h</span>ave poorer <span class="attribute-to-highlight medbox">h</span>ealth accesses, lower education achievements, less social and economic participation and less rate of income than Persons disabilities experience barriers in accessing services that many of us <span class="attribute-to-highlight medbox">h</span>ave long taken for granted, including <span class="attribute-to-highlight medbox">h</span>ealth, education, employment, transport and information as well as rehabilitation. These difficulties are exacerbated with <span class="attribute-to-highlight medbox">h</span>igh level of disability disadvantaged individuals. Based on the findings of this study, major socio-economic remedy directions are recommended which will be included in future policy enactment and implementations.