La crise humanitaire récente qui a sévit en Centrafrique a entrainé l’arrivée d’un nombre important d’acteurs humanitaires dans le pays, afin de pouvoir répondre aux besoins considérables des populations vulnérables. Cet afflux d’acteurs humanitaires, combiné aux changements politico...-sécuritaires dans le pays, ont eu pour conséquence, entres autres, de rendre plus difficile, et l’importation de biens nécessaires à l’assistance humanitaire dans le pays. En effet, bien que la Lois des finances ( 2015) et différends Arrêtés more

Buruli ulcer caused by Mycobacterium ulcerans is a neglected tropical disease characterized by extensive ulceration involving predominantly the upper and lower limbs of patients. The disease is common in rural tropical communities in West and Central Africa, where access to proper health care is lim...ited. Pathogenesis of the characteristic painless ulcers is linked to the elaboration by M. ulcerans of a lipid toxin called mycolactone that has potent cytopathic, immunosuppressive, and analgesic effects on a host of cells in cutaneous tissues. Mycolactone is known to profoundly inhibit secretion of a plethora of proteins that are essential for wound healing. Even though a combination antibacterial therapy of streptomycin and rifampicin for 8 weeks is effective for treatment, it relies on good and appropriate wound management to prevent secondary bacterial infections and improve healing. Evidence-based interventions for wound care in Buruli ulcer disease are often lacking and have relied on expert advice and recommendations. Surgical interventions are limited to debridement of necrotic tissue and grafting of extensive ulcers, usually after antibiotic therapy. Patients’ rehabilitation is an important component of care to reduce disabilities associated with the disease and proper integration into the community after treatment. more