COVID-19 vaccine hesitancy is currently one of the main obstacles to worldwide herd immunity <span class="attribute-to-highlight medbox">and</span> socioeconomic recovery. Because vaccine coverage can vary between <span class="attribute-to-highlight medbox">and</span> within countries, it is important to identify sources of variation so that policies can be tailored to different population groups. In this paper, we analyze the results from a survey designed <span class="attribute-to-highlight medbox">and</span> implemented in order to identify <span class="attribute-to-highlight medbox">early</span> <span class="attribute-to-highlight medbox">adopters</span> <span class="attribute-to-highlight medbox">and</span> <span class="attribute-to-highlight medbox">laggers</span> in six big cities of Latin America. We find that trust in government <span class="attribute-to-highlight medbox">and</span> science, accurate knowledge about the value of vaccination <span class="attribute-to-highlight medbox">and</span> vaccine effects, perceived risk of getting sick, <span class="attribute-to-highlight medbox">and</span> being a student increase the odds to get vaccinated. We also identify potential <span class="attribute-to-highlight medbox">laggers</span> as women <span class="attribute-to-highlight medbox">and</span> populations between 20 <span class="attribute-to-highlight medbox">and</span> 35 years old who are not students. We discuss specific strategies to promote vaccination among these populations groups as well as more general strategies designed to gain trust. These findings are specific to the context of Latin America insofar as the underlying factors associated with the choice to be vaccinated vary significantly by location <span class="attribute-to-highlight medbox">and</span> in relation to individual-level factors.