To evaluate the epidemiological evolution of patients with HIV (PtHIV), between 2002 and 2012, in <span class="attribute-to-highlight medbox">a</span> day-hospital that became an HIV reference centre for south-west Burkina Faso. This was <span class="attribute-to-highlight medbox">a</span> retrospective study of PtHIV followed in the Bobo Dioulasso university hospital since 2002. The study was based on clinical data recorded using ESOPE software and analysed using Excel and SAS.