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After 100 years of chemotherapy with impractical and toxic drugs, an oral cure for human African trypanosomiasis (HAT) is available: Fexinidazole. In this case, we review the history of drug discovery for HAT with special emphasis on the discovery, pre-clinical development, and operational challenge...
The twentieth century ended with human African trypanosomiasis (HAT) epidemics raging across many parts of Africa. Resistance to existing drugs was emerging, and many programs aiming to contain the disease had ground to a halt, given previous success against HAT and the competing priorities associat...
Mental Health Toolkit
recommended
While working with survivors and victims of domestic abuse, we have learned that
many people who have experienced abuse or trauma in their lives also experience mental health issues as a direct effect of what they have been through. This is why Chayn has created a Mental Health Toolkit available fo...
Front. Hum. Neurosci., 25 September 2009 | https://doi.org/10.3389/neuro.09.026.2009
Externalising disorders
Chapter D.3
Arsenical monotherapies were previously very successful for treating human African trypanosomiasis (HAT).
Melarsoprol resistance emerged as early as the 1970s and was widespread by the late 1990s.
Melarsoprol resistance represents the only example of widespread drug resistance in HAT patients wher...
