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Therapeutics and COVID-19 (Living Guideline, 10 November 2023)

World Health Organization WHO (2023) C_WHO

WHO has updated its guidelines for COVID-19 therapeutics, with revised recommendations for patients with non-severe COVID-19. This is the 13th update to these guidelines. Updated risk rates for hospital admission in patients with non-severe COVID-19 The guidance includes updated risk rates for... hospital admission in patients with non-severe COVID-19. The current COVID-19 virus variants tend to cause less severe disease while immunity levels are higher due to vaccination, leading to lower risks of severe illness and death for most patients. This update includes new baseline risk estimates for hospital admission in patients with non-severe COVID-19. The new ‘moderate risk’ category now includes people previously considered to be high risk including older people and/or those with chronic conditions, disabilities, and comorbidities of chronic disease. The updated risk estimates will assist healthcare professionals to identify individuals at high, moderate or low risk of hospital admission, and to tailor treatment according to WHO guidelines: **High: **People who are immunosuppressed remain at higher risk if they contract COVID-19, with an estimated hospitalization rate of 6%. **Moderate: **People over 65 years old, those with conditions like obesity, diabetes and/or chronic conditions including chronic obstructive pulmonary disease, kidney or liver disease, cancer, people with disabilities and those with comorbidities of chronic disease are at moderate risk, with an estimated hospitalization rate of 3%. Low: Those who are not in the high or moderate risk categories are at low risk of hospitalization (0.5%). Most people are low risk. Review of COVID-19 treatments for people with non-severe COVID-19 WHO continues to strongly recommend nirmatrelvir-ritonavir (also known by its brand name ‘Paxlovid’) for people at high-risk and moderate risk of hospitalization. The recommendations state that nirmatrelvir-ritonavir is considered the best choice for most eligible patients, given its therapeutic benefits, ease of administration and fewer concerns about potential harms. Nirmatrelvir-ritonavir was first recommended by WHO in April 2022. If nirmatrelvir-ritonavir is not available to patients at high-risk of hospitalization, WHO suggests the use of molnupiravir or remdesivir instead. WHO suggests against the use of molnupiravir and remdesivir for patients at moderate risk, judging the potential harms to outweigh the limited benefits in patients at moderate risk of hospital admission. For people at low risk of hospitalization, WHO does not recommend any antiviral therapy. Symptoms like fever and pain can continue to be managed with analgesics like paracetamol. WHO also recommends against use of a new antiviral (VV116) for patients, except in clinical trials. The update also includes a strong recommendation against the use of ivermectin for patients with non-severe COVID-19. WHO continues to advise that in patients with severe or critical COVID-19, ivermectin should only be used in clinical trials. more

Access to NCD medicines: emergent issues during the COVID-19 pandemic and key structural factors 2023

World Health Organization WHO (2023) C_WHO

The coronavirus disease (COVID-19) pandemic exacerbated pre-existing inequalities in the treatment and care of noncommunicable diseases (NCDs). This report examines the effect of the COVID-19 pandemic on access to NCD medicines, and the policies and strategies implemented by countries and health sys... more

Publication: Gendered Impacts of the COVID-19 Crisis in Uganda and Opportunities for an Inclusive and Sustainable Recovery

Alys, W.; Aziz, A.; Caran Ann, M. (2022) CC2

As Uganda builds back from the COVID-19 shock, the Ugandan government is strengthening its commitment to a more gender-inclusive and sustainable economy. This report supports these efforts by describing the gendered impacts of COVID-19 and provides recommendations for Ugandan policy makers and World... more

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Ebola and HIV

Caritas Internationalis (2014)

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Patient Information Sheet – Acute HIV Infection Information about Acute HIV Infection and PrEP

Centers for Diseases Control and Prevention (2019) C_CDC

National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention Division of HIV/AIDS Prevention Accessed: 03.09.2019

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Adapting and implementing new recommendations on HIV case surveillance

World Health Organization (2017) C_WHO

HIV patient monitoring and case surveillance

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COVID-19: Inclusive programming – Ensuring assistance and protection addresses the needs of marginalized and at-risk people

International Committee of the Red Cross (ICRC) International Committee of the Red Cross (ICRC) (2020) C2

March 2020

External Link

Violence against women during COVID-19

World Health Organization WHO (2020) C1

Questions & Answers

COVID-19 and Women’s Human Rights: Guidance -What is the Impact of COIVD-19 on Gender-based Violence?

Reliefweb; OCHA Services; United Nations of Human Rights (Office of the High Commissioner); COVID-19 Response (2020) CC

Putting Human Rights at the Heart of the Response Topic in Focus: COVID-19 and Women’s Human Rights 15 April 2020 Stay-at-home restrictions and other measures restricting the movement of people contribute to an increase in genderbased violence, a finding confirmed by media reports, official ... more

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Women and Girls Safe Spaces: Technical Guidance Note for COVID-19

Norwegian Church Aid, International Medical Corps, International Red Cross (2020) CC

This guidance note aims to provide practical support to service providers operating Women and Girls Safe Spaces (WGSS) on how to adapt programming in the context of the COVID-19 pandemic.

Disrupting Covid-19 Stigma

USAID, Breakthrough Action (2020) CC

In the context of health, stigma is the negative association between a person or group of people who share certain characteristics and a specific disease. In an outbreak, this may mean people are labeled, stereotyped, discriminated against, treated separately, and/or experience loss of status becaus... more

Understanding the Impact of COVID-19

Assessment Capacities Project ACAPS (2020) C2

This report provides an overview of the key information gaps and limitations in interpreting existing COVID-19 data

Covid-19 RCCE Strategies for Cross-Border Movement in Eastern and Southern Africa

Social Science in Humanitarian Action (2020) CC

Key Considerations This brief focuses on cross-border movement in Eastern and Southern Africa (ESA) and its implications for development of risk communication and community engagement (RCCE) strategies aimed at preventing transmission of COVID-19 in the ESA region. Given the extensive risk of cross... more

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El Salvador: The country's President takes the lead in promoting a stringent lockdown against COVID-19 with support from all levels, including the PAHO/WHO country office

World Health Organization WHO (2021) C_WHO

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Inequitable access to COVID-19 tools: A snapshot across 503 facilities in Africa, Asia, and Eastern Europe and Central Asia

The Global Fund (2021) CC

Nói về COVID 19 - Talking about COVID-19

Nữ tu Bác sĩ Nguyễn Thị Hiền Unicef (2020) C2

Talking About Corona-19 in English and Vietnamese Informations for Kids

Policy Guidelines for Collaborative TB and HIV Services for Injecting and Other Drug Users: An Integrated Approach

World Health Organization, UNAIDS, United Nations Office on Drugs and Crime (2008)

These policy guidelines provide a strategic approach and new recommendations for integrated TB and HIV services for patients suffering from substance-abuse addiction. The key recommendations fall under three main categories: joint planning, key interventions, and overcoming barriers.

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Zimbabwe Demographic and Health Survey 2010-11

Zimbabwe National Statistics Agency (Z IMSTAT) and ICF International. 20 (2012) C1

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Maternal Iron and Vitamin A Supplementation and the Nutritional Status of Children in the 2010-11 Zimbabwe Demographic and Health Survey
recommended

S. Gwavuya; C. Murendo; N. Wekwete; et al. ICF International, et al. (2014) C1

External Link

2015 Pipeline Report HIV, Hepatitis C virus (HCV), and Tuberculosis (TB)

Polly Clayden, Simon Collins, Mike Frick, et al. A. Benzacar; HIV i-BASETREATMENT ACTION GROUP (2015)

Drugs, Diagnostics, Vaccines, Preventive Technologies, Research toward a cure, and immune-based and gene therapies in development

Maternal Iron and Vitamin A Supplementation and the Nutritional Status of Children in the 2010-11 Zimbabwe Demographic and Health Survey recommended

Maternal Iron and Vitamin A Supplementation and the Nutritional Status of Children in the 2010-11 Zimbabwe Demographic and Health Survey
recommended