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Developing New Diagnostic Tests for Human African Trypanosomiasis - Current status and future plans

HAT & OND Team Foundation for innovative new diagnostics FIND (2013) C2
FIND and Standard Diagnostics (SD) have developed a lateral flow rapid diagnostic test (RDT) to screen for T.b. gambiense HAT that is cheap and easy to use. The tests are packed individually and are stable at 40°C for up to 25 months; they are performed on fresh blood obtained from a finger prick... more
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Epidemiological and clinical aspects of urogenital schistosomiasis in women, in Burkina Faso, West Africa

Zida, A.; Briegel, J.; Kabré, I. et al. BioMed Central (2016) CC
Human schistosomiasis, a parasitic and often chronic illness, is one of the major neglected tropical diseases worldwide. It is estimated that 240 million people suffer from schistosomiasis, with more than 200000 fatalities recorded each year. Schistosomiasis is caused by an infection of the blood fl... more
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Diagnosis and Clinical Management of Chagas Disease: An Increasing Challenge in Non-Endemic Areas

Suárez, C., Nolder, D., García-Mingo, A. et al. Research and reports in tropical medicine (2022) CC
Chagas disease (CD) is caused by the parasite Trypanosoma cruzi, and it is endemic in Central, South America, Mexico and the South of the United States. It is an important cause of early mortality and morbidity, and it is associated with poverty and stigma. A third of the cases evolve into chronic... more
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Report of the fourth WHO stakeholders meeting on gambiense and rhodesiense human African trypanosomiasis elimination: virtual meeting, 1–3 June 2021

World Health Organization WHO (2021) C_WHO
Since 2000, concerted efforts by national programmes, supported by public–private partnerships, nongovernmental organizations, donors and academia under the auspices and coordination of the World Health Organization (WHO), have produced important achievements in the control of human African trypan... more
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Knowledge, attitudes and practices about human African trypanosomiasis and their implications in designing intervention strategies for Yei county, South Sudan

Bukachi, SA.; Mumbo, AA.; Alak, ACD.; Sebit, W.; Rumunu, J. et al. PLOS Neclected Tropical Diseases (2018) CC
A clear understanding of the knowledge, attitudes and practices (KAP) of a particular community is necessary in order to improve control of human African trypanosomiasis (HAT).New screening and diagnostic tools and strategies were introduced into South Sudan, as part of integrated delivery of primar... more
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Melarsoprol Resistance in African Trypanosomiasis

Fairlamb, A.H.; Horn, D. Elsevier Ltd. (2018) CC
Arsenical monotherapies were previously very successful for treating human African trypanosomiasis (HAT). Melarsoprol resistance emerged as early as the 1970s and was widespread by the late 1990s. Melarsoprol resistance represents the only example of widespread drug resistance in HAT patients wher... more
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Target product profile for a test for rhodesiense human African trypanosomiasis diagnosis usable in peripheral health facilities

World Health Organization WHO (2021) C_WHO
The development of this target product profile (TPP) was led by the WHO Department of Control of Ne- glected Tropical Diseases (NTD) following standard WHO guidance for TPP development. In order to identify and prioritize diagnostic needs, a WHO NTD Diagnostics Technical Advisory Group (DTAG) was... more
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Accelerating towards human African trypanosomiasis elimination: Issues and opportunities

Ozioko ,KU.; Okoye, CI.; Obiezue, RN.; Idika, IK.; Awudu, RA.; Ezewudo, BI.; Ezea, CO. (2019) CC
Human African trypanosomiasis (HAT) has been an alarming global public health issue. The disease affects mainly poor and marginalized people in low-resource settings and is caused by two subspecies of haemoflagellate parasite, Trypanosoma brucei and transmitted by tsetse flies. Progress made in HAT ... more
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Tsetse Control and Gambian Sleeping Sickness; Implications for Control Strategy

Tirados, I.; Esterhuizen, J.; Kovacic, V.; Mangwiro, TNC.; Vale, GA et al. PLOS Neglected Tropical Diseases (2015) CC
Sleeping sickness is controlled by case detection and treatment but this often only reaches less than 75% of the population. Vector control is capable of completely interrupting HAT transmission but is not used because of expense. We conducted a full scale field trial of a refined vector control tec... more
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WASH and health working together: a ‘how-to’ guide for neglected tropical disease programmes, 2nd ed

World Health Organisation (WHO) (2023) C_WHO
The equity focus set out by the 2030 Agenda for Sustainable Development demands new ways to extend services to unserved populations. Successful water, sanitation and hygiene (WASH) and neglected tropical disease (NTD) partnerships have the potential to help achieve this ambition. However, working to... more
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Gambiense human African trypanosomiasis: the bumpy road to elimination

Hasker E, Hope A, Bottieau E. Wolters Kluwer Health, Inc. (2022) C2
Gambiense human African trypanosomiasis is a deadly infectious disease affecting West and Central Africa, South Sudan and Uganda, and transmitted between humans by tsetse flies. The disease has caused several major epidemics, the latest one in the 1990s. Thanks to recent innovations such as rapid di... more
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New hope for leishmaniasis

Drugs for Neglected Diseases initiative DNDi (2022) CC
Leishmaniasis is a climate-sensitive disease. Changes in temperature, rainfall, and humidity can have strong impacts on the sandfly vector, altering their distribution and influencing their survival and population sizes. Increased temperatures shorten vector development time, reduce Leishmania p... more
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Ethiopia - Multi-Sectorial Cholera Elimination Plan 2022 - 2028

Government of Ethiopia (2023) CC
Cholera which disproportionally impacts poor countries and the most vulnerable continues to affect at least 47 countries across the globe, resulting in an estimated 1.3 – 4 million cases, and 21,000 - 143,000 deaths per year worldwide. In Ethiopia, despite major improvements seen in the increasing... more
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Responding to child maltreatment: a clinical handbook for health professionals

World Health Organisation (WHO) (2022) C_WHO
This handbook is intended primarily for front-line health care providers who are likely to see children (among other clients) in their day-to-day practice. These may include general practitioners, nurses, midwives, gynaecologists, paediatricians, mental health professionals, first responders and st... more
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Communicating with caregivers about the Human Papillomavirus vaccination

World Health Organisation (WHO) (2023) C_WHO
This training module is designed to equip health workers (HWs) with knowledge, skills, confidence and resources to help them in their role to recommend the Human Papillomavirus (HPV) vaccine.
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Modelling COVID-19 vaccination status and adherence to public health and social measures, Eastern Mediterranean Region and Algeria

World Health Organisation (WHO) (2023) C_WHO
The introduction of vaccines for coronavirus disease 2019 (COVID-19) added another measure to the existing set of recommended preventive measures (wearing a mask in public, keeping a distance from other people and regular handwashing). The roll-out of the vaccines, however, raised concerns that vac... more
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Congenital Chagas disease: Updated recommendations for prevention, diagnosis, treatment, and follow-up of newborns and siblings, girls, women of childbearing age, and pregnant women

Carlier, Y.; Altcheh, J.; Angheben, A. et al. PLOS Neglected Tropical Diseases (2019) CC
In 2005, the World Health Organization (WHO) recognized Chagas disease (CD; Trypanosoma cruzi infection) as a neglected tropical disease (NTD) [1] and included it into the global plan to combat NTDs [2]. The Target 3.3 of the United Nations Sustainable Development Goals (UN/SDG) aims at ending the e... more
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Chagas Disease: Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV

Panel on Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV Clinical Info HIV (2018) CC
Epidemiology Chagas disease (American trypanosomiasis) is caused by the protozoan parasite Trypanosoma cruzi, and transmitted to humans by infected triatomine bugs, and less commonly by transfusion, organ transplant, from mother to infant, and in rare instances, by ingestion of contaminated food or... more
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Guidelines for the Prevention and Treatment of Opportunistic Infections

Clinical Info HIV gov. (2018) CC
Chagas disease (American trypanosomiasis) is caused by the protozoan parasite Trypanosoma cruzi, and transmitted to humans by infected triatomine bugs, and less commonly by transfusion, organ transplant, from mother to infant, and in rare instances, by ingestion of contaminated food or drink.1-4 The... more
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Rassismus in Deutschland. Ausgangslage, Handlungsfelder, Maßnahmen

Alabali-Radovan, R. Die Beauftragte der Bundesregierung für Migration, Flüchtlinge und Integration; Die Beauftragte der Bundesregierung für Antirassismus (2023) C2
Dieser Lagebericht ist eine Premiere und ich möchte als Integrationsbeauftragte und zugleich Antirassismusbeauftragte der Bundesregierung damit in bewegten, aufgewühlten Zeiten erklären und einordnen, mehr Verständigung und Verständnis schaffen. Erstmals liegt mit meinem Bericht ein Dokument d... more