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HIV and tuberculosis co-infection programmes

Avert Avert (2019) C2

People living with HIV who have a low CD4 count are at a much higher risk of falling ill from TB infection than HIV negative people. It is important to offer both HIV testing to TB patients and TB diagnosis in HIV patients. Early detection and effective treatment are essential to preventing TB... more

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Radiological and Nuclear Terrorism: Medical Response to Mass Casualties

Centers for Disease Control and Prevention (CDC) (2006) C_CDC

The purpose of this training is to prepare clinicians in first receiver settings to: (1) Identify factors impacting immediate medical response to mass casualties following major types of radiological incidents, and (2) Demonstrate appropriate patient assessment, triage, treatment and disposition dec... more

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occupied Palestinian territory COVID-19 Response Plan (27 March 2020)

UN Office for the Coordination of Humanitarian Affairs (OCHA) (2020) C_WHO

The primary focus of the plan continues to be prevention, preparedness and treatment of the the Novel Coronavirus (COVID-19) outbreak. Central to the plan are the following overall objectives: To prevent further transmission of COVID-19 in the oPt; To provide adequate care for patients aff... more

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Evaluation of the Affordable Medicines Programme in Ukraine

World Health Organization WHO, Regional Office of Europe (2019) C_WHO

This report reviews and analyses the Affordable Medicines Programme, which was introduced in Ukraine in April 2017 to provide patients with improved access to 23 outpatient medicines for the treatment of chronic noncommunicable diseases. The evaluation combines both quantitative and qualitative anal... more

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Learn more about monkeypox as we record first confirmed case in SA

Saphra (2022) CC

South Africa has recorded its first case of monkeypox today, 23 June 2022. The Minister of Health Dr. Joe Phaahla explained that he received a report from the National Health Laboratory Services’ CEO that they have confirmed through laboratory tests the first case of monkeypox in South Africa. ... more

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New Therapeutics for Chagas Disease: Charting a Course to Drug Approval

Man, A. & Segal, F. Intechopen (2022) CC

DOI: 10.5772/intechopen.102891Little progress has been made since the 1960s and 19. 70s to widen the therapeutic arsenal against Trypanosoma cruzi, the causative pathogen of Chagas disease, which remains a frustrating and perplexing infectious disease. This chapter focuses on the strategic and opera... more

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Therapeutics and COVID-19 (Living Guideline, 10 November 2023)

World Health Organization WHO (2023) C_WHO

WHO has updated its guidelines for COVID-19 therapeutics, with revised recommendations for patients with non-severe COVID-19. This is the 13th update to these guidelines. Updated risk rates for hospital admission in patients with non-severe COVID-19 The guidance includes updated risk rates for... hospital admission in patients with non-severe COVID-19. The current COVID-19 virus variants tend to cause less severe disease while immunity levels are higher due to vaccination, leading to lower risks of severe illness and death for most patients. This update includes new baseline risk estimates for hospital admission in patients with non-severe COVID-19. The new ‘moderate risk’ category now includes people previously considered to be high risk including older people and/or those with chronic conditions, disabilities, and comorbidities of chronic disease. The updated risk estimates will assist healthcare professionals to identify individuals at high, moderate or low risk of hospital admission, and to tailor treatment according to WHO guidelines: **High: **People who are immunosuppressed remain at higher risk if they contract COVID-19, with an estimated hospitalization rate of 6%. **Moderate: **People over 65 years old, those with conditions like obesity, diabetes and/or chronic conditions including chronic obstructive pulmonary disease, kidney or liver disease, cancer, people with disabilities and those with comorbidities of chronic disease are at moderate risk, with an estimated hospitalization rate of 3%. Low: Those who are not in the high or moderate risk categories are at low risk of hospitalization (0.5%). Most people are low risk. Review of COVID-19 treatments for people with non-severe COVID-19 WHO continues to strongly recommend nirmatrelvir-ritonavir (also known by its brand name ‘Paxlovid’) for people at high-risk and moderate risk of hospitalization. The recommendations state that nirmatrelvir-ritonavir is considered the best choice for most eligible patients, given its therapeutic benefits, ease of administration and fewer concerns about potential harms. Nirmatrelvir-ritonavir was first recommended by WHO in April 2022. If nirmatrelvir-ritonavir is not available to patients at high-risk of hospitalization, WHO suggests the use of molnupiravir or remdesivir instead. WHO suggests against the use of molnupiravir and remdesivir for patients at moderate risk, judging the potential harms to outweigh the limited benefits in patients at moderate risk of hospital admission. For people at low risk of hospitalization, WHO does not recommend any antiviral therapy. Symptoms like fever and pain can continue to be managed with analgesics like paracetamol. WHO also recommends against use of a new antiviral (VV116) for patients, except in clinical trials. The update also includes a strong recommendation against the use of ivermectin for patients with non-severe COVID-19. WHO continues to advise that in patients with severe or critical COVID-19, ivermectin should only be used in clinical trials. more

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Diagnóstico rápido: Situación de los migrantes venezolanos con VIH en el Perú

ONUSIDA (2019) C1

Thousands of HIV-positive Venezuelans have been forced to leave the country, after facing discrimination and zero treatment options, according to UNAIDS. Patients once received free ARV treatment under Venezuela’s National AIDS Program. In 2017, the country essentially ran out of ARVs—about 9 p... more

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ОЦІНКА ПРОГРАМИ «ДОСТУПНІ ЛІКИ» В УКРАЇНІ

World Health Organization WHO, Regional Office of Europe (2019) C_WHO

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Buruli ulcer: wound care and rehabilitation

Frimpong, M.; F. S.Sarfo, M. Sarpong Duah, et al. Dove Medical Press Limited (2016) C1

Buruli ulcer caused by Mycobacterium ulcerans is a neglected tropical disease characterized by extensive ulceration involving predominantly the upper and lower limbs of patients. The disease is common in rural tropical communities in West and Central Africa, where access to proper health care is lim... more

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The Mark of Neglect: Cutaneous Leishmaniasis

Drugs for Neglected Diseases initiative DNDi (2014) CC

Leishmaniasis is among the most neglected diseases. The most common form is cutaneous leishmaniasis that forms lesions on the skin. The only treatment available for cutaneous leishmaniasis is highly toxic. In some cases, patients have died because of the treatment, even though cutaneous leishmania... more

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Public–private mix for TB prevention and care: a roadmap

World Health Organization WHO (2018) C_WHO

In 2017, 3.6 million of the estimated 10 million people with TB worldwide were “missed” by national TB programmes (NTPs). Two thirds of them are thought to access TB treatment of questionable quality from public and private providers who are not engaged by the NTP. The quality of care provided i... more

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Guidelines for the Management of Multidrug-Resistant Tuberculosis (MDR-TB) in Myanmar

The Republic of the Union of Myanmar, Ministry of Health, Department of Health, National Tuberculosis Programme (2013) C_WHO

Following the encouraging initial results of the pilot project, the Ministry of Health is committed to increasing access to MDR-TB diagnosis, treatment and care. An expansion plan for the programmatic management of drug-resistant TB has been developed and forms part of the Five Year National Strateg... more

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Optimized Supportive Care for Ebola Virus Disease
recommended

World Health Organization WHO (2019) C_WHO

Clinical management standard operating procedures. Ebola virus disease (EVD) is a life-threatening multisystem illness associated with fever and gastrointestinal (GI) symptoms that frequently leads to hypovolaemia, metabolic acidosis, hypoglycaemia, and multi-organ failure. The prolonged 2013–201... more

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Let's talk TB: a free, online book for primary care providers

Madhukar Pai GP clinics (2018) CC

The third edition, released in 2018, has grown to include a total of 18 chapters, contributed by 20 experts and authors from many countries. The goal remains the same: to educate primary care providers on the best practices in TB diagnosis, treatment and follow-up. All articles are richly illustrate... more

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Review on palliative care with focus on 18 high tuberculosis priority countries

World Health Organization WHO, Regional Office of Europe (2021) C_WHO

Tuberculosis (‎TB)‎ is, and should be, a curable disease; however, each year significant numbers of patients acquire or develop drug-resistant TB, which has a much lower cure rate. Patients with drug-resistant TB have a high prevalence of symptoms; hence, staff caring for these patients should h... more

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Medical Management Guidelines (MMGs)

Agency for Toxic Substances & Disease Registry (2014)

The Medical Management Guidelines (MMGs) for Acute Chemical Exposures were developed by ATSDR to aid emergency department physicians and other emergency healthcare professionals who manage acute exposures resulting from chemical incidents. The MMGs are intended to aid healthcare professionals involv... more

Optimized Supportive Care for Ebola Virus Disease recommended

Optimized Supportive Care for Ebola Virus Disease
recommended