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Government policy interventions to reduce human antimicrobial use: A systematic review and evidence map

Van Katwyk, S. R.; Grimshaw, J. M.; et al (2019) C2

BACKGROUND: Growing political attention to antimicrobial resistance (AMR) offers a rare opportunity for achieving meaningful action. Many governments have developed national AMR action plans, but most have not yet implemented policy interventions to reduce antimicrobial overuse. A systematic evidenc...e map can support governments in making evidence-informed decisions about implementing programs to reduce AMR, by identifying, describing, and assessing the full range of evaluated government policy options to reduce antimicrobial use in humans. METHODS AND FINDINGS: Seven databases were searched from inception to January 28, 2019, (MEDLINE, CINAHL, EMBASE, PAIS Index, Cochrane Central Register of Controlled Trials, Web of Science, and PubMed). We identified studies that (1) clearly described a government policy intervention aimed at reducing human antimicrobial use, and (2) applied a quantitative design to measure the impact. We found 69 unique evaluations of government policy interventions carried out across 4 of the 6 WHO regions. These evaluations included randomized controlled trials (n = 4), non-randomized controlled trials (n = 3), controlled before-and-after designs (n = 7), interrupted time series designs (n = 25), uncontrolled before-and-after designs (n = 18), descriptive designs (n = 10), and cohort designs (n = 2). From these we identified 17 unique policy options for governments to reduce the human use of antimicrobials. Many studies evaluated public awareness campaigns (n = 17) and antimicrobial guidelines (n = 13); however, others offered different policy options such as professional regulation, restricted reimbursement, pay for performance, and prescription requirements. Identifying these policies can inform the development of future policies and evaluations in different contexts and health systems. Limitations of our study include the possible omission of unpublished initiatives, and that policies not evaluated with respect to antimicrobial use have not been captured in this review. CONCLUSIONS: To our knowledge this is the first study to provide policy makers with synthesized evidence on specific government policy interventions addressing AMR. In the future, governments should ensure that AMR policy interventions are evaluated using rigorous study designs and that study results are published. more

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Buruli ulcer: wound care and rehabilitation

Frimpong, M.; F. S.Sarfo, M. Sarpong Duah, et al. Dove Medical Press Limited (2016) C1

Buruli ulcer caused by Mycobacterium ulcerans is a neglected tropical disease characterized by extensive ulceration involving predominantly the upper and lower limbs of patients. The disease is common in rural tropical communities in West and Central Afric..., where access to proper health care is limited. Pathogenesis of the characteristic painless ulcers is linked to the elaboration by M. ulcerans of a lipid toxin called mycolactone that has potent cytopathic, immunosuppressive, and analgesic effects on a host of cells in cutaneous tissues. Mycolactone is known to profoundly inhibit secretion of a plethora of proteins that are essential for wound healing. Even though a combination antibacterial therapy of streptomycin and rifampicin for 8 weeks is effective for treatment, it relies on good and appropriate wound management to prevent secondary bacterial infections and improve healing. Evidence-based interventions for wound care in Buruli ulcer disease are often lacking and have relied on expert advice and recommendations. Surgical interventions are limited to debridement of necrotic tissue and grafting of extensive ulcers, usually after antibiotic therapy. Patients’ rehabilitation is an important component of care to reduce disabilities associated with the disease and proper integration into the community after treatment. more

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The path that ends AIDS: UNAIDS Global AIDS Update 2023
recommended

UN Children's Fund UNICEF (2023) CC

This report makes clear that there is a path to end AIDS. Taking that path will help ensure preparedness to address other pandemic challenges, and advance progress across the Sustainable Development Goals. The data and real-world examples in the rep... more

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Donor Funding for Newborn Survival: An Analysis of Donor-Reported Data, 2002–2010

Pitt1, C.; J. E. Lawn; M. Ranganathan et al. PLoS Med (2012) CC

Background:Neonatal mortality accounts for 43% of global under-five deaths and is decreasing more slowly than maternal or child mortality. Donor funding has increased for maternal, newborn, and child health (MNCH), but no analysis to date has disagg... more

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Healthy Living Toolkit

US Committee for Refugees and Immigrants (2015) CC

The Healthy Living Toolkit is developed to educate refugees, immigrants, resettlement agencies, clinics, community based organizations, and other service providers on refugee health issues. The tool... more

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First, Do No Harm - Examining the impact of the IFC’s support to private healthcare in India

Anjela Taneja and Amitabha Sarkar Oxfam International (2023) CC

This report examines the support to private healthcare provision in India by the World Bank’s private sector arm, the International Finance Corporation (IFC). Despite supporting private healthcare in the country since 1997, no healthcare results f... more

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The Condition of the Girl Child worldwide - Fifth Edition

Indefes - Terre des Hommes (2016) C1

In the last five years, i.e. how old turned the Campaign “Indifesa” (Defenceless) in 2016, that was launched by Terre des Hommes in 2012, the world has become smaller. One can actually say that the derangements following the Arab Spring in 2011 ... more

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The Ignored Pandemic: The Dual Crisis of Gender-Based Violence and COVID-19

Oxfam (2021) CC

24 Nov. 2021 Action against gender-based violence being pushed to the outlying margins of the global COVID-19 response A new Oxfam report shows an undeniable increase in gender-based violence (GBV) during the COVID-19 pandemic around the world t... more

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AidData's Tracking Underreported Financial Flows (TUFF) Methodology, Version 1.3.

Strange, A.; M. Cheng; B. Russell et al. AidData at William & Mary (2017) CC

This codebook outlines the set of TUFF procedures that have been developed, tested, refined, and implemented by AidData staff and affiliated faculty at the College of William & Mary. We initially employed these methods to achieve a specific objective: documenting the known universe of officially fin... more

A lifeline to learning - Leveraging technology to support education for refugees

UNESCO Education 2030 (2020) CC

Education is UNESCO’s top priority because it is a basic human right and the foundation on which to build peace and drive sustainable development. UNESCO is the United Nations’ specialized agency for education and the Education Sector provides global and ... leadership in education, strengthens national education systems and responds to contemporary global challenges through education with a special focus on gender equality and Africa. more

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Review of Evidence on Antimicrobial Resistance and Animal Agriculture in Developing Countries

Grace, D. International Livestock Research Institute (ILRI) (2015) C2

This short paper aims to identify key evidence gaps in our knowledge of livestock- and fisheries-linked antimicrobial resistance in the developing world, and to document on-going or planned research initiatives on this topic by key stakeholders. Th... more

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How to Investigate Antimicrobial Use in Hospitals: Selected Indicators

USAID; Strengthening Pharmaceutical Systems (2008) C1

The purpose of this manual is to define a limited number of indicators that will objectively describe the management and use of antimicrobials in hospitals and to provide tools and step-by-step instructions for designing and carrying out an assessment of antibiotic use and management in hospitals. T... more

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A double dose of inequality; Pharma companies and the Covid-19 vaccines crisis

Amnesty International (2022) C2

22 Sept. 2021 The rapid development of effective Covid-19 vaccines in 2020 gave hope to the world in the darkest days of the deadly pandemic. However, the vaccine roll-out has been massively skewed towards wealthy nations. While rich states have ho... more

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In Control - A Practical Guide for Civilian Experts Working in Crisis Management Missions

Center for International Peace Operations (2016) CC

Hands-on information and practical advice for everyday life and work in the field as well as background information on crisis management structures in international organizations lie at the heart of the new handbook. It has been developed in the rea... more

UNHCR Report "On this journey, no one cares if you live or die"

D. Breen UNHCR; Mixed Migration Centre (2020) CC

Refugees and migrants face unacceptable and extreme forms of violence on mixed migration routes from East and West Africa to and through North Africa. This report provides clear and strong findings ... more

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Managing the Pandemic and Its Aftermath: Economies, Jobs, and International Migration in the Age of COVID-19

Migration Policy Institute (2020) C1

The COVID-19 pandemic’s immediate costs, measured in lives lost and damaged, have been appalling and continue to rise. In addition, its effects on individuals’ livelihoods and economies around the world have been deep and are likely to be long l... more

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The one health landscape in Sub-Saharan African countries

F. O. Fasina, Fasanmi O.G., Makonnen Y. J., et al. (2021) CC

Impact of the COVID-19 pandemic on blood supply and demand in the WHO African Region

Loua, A.; et al. (2021) C_WHO

VOX Sanguinis, 2021: The coronavirus disease 2019 (COVID-19) affected millions of people worldwide and caused disruptions at the global level including in healthcare provision. Countries of the WHO Afric...n region have put in place measures for the COVID-19 pandemic containment that may adversely affect blood system activities and subsequently reduce the supply and demand of blood and blood components. This study aims to assess the impact of the COVID-19 pandemic on blood supply and demand in the WHO African Region and propose measures to address the challenges faced by countries. more

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World Happiness Report 2021

Helliwell, John F., Richard Layard, Jeffrey Sachs, and Jan-Emmanuel De Neve Sustainable Development Solutions Network (2021) CC

The World Happiness Report 2021 focuses on the effects of COVID-19 and how people all over the world have fared. Our aim was two-fold, first to focus on the effects of COVID-19 on the structure and ... more

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WHO Guidelines on Preventing Early Pregnancy and Poor Reproductive Outcomes Among Adolescents in Developing Countries

WHO (2011)

Recommendations on action and research for: a) preventing early pregnancy b) preventing poor reproductive outcomes

The path that ends AIDS: UNAIDS Global AIDS Update 2023 recommended

The path that ends AIDS: UNAIDS Global AIDS Update 2023
recommended