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Government policy interventions to reduce human antimicrobial use: A systematic review and evidence map

Van Katwyk, S. R.; Grimshaw, J. M.; et al (2019) C2

BACKGROUND: Growing political attention to antimicrobial resistance (AMR) offers a rare opportunity for achieving meaningful action. Many governments have developed national AMR action plans, but most have not yet implemented policy interventions to reduce antimicrobial overuse. A systematic evidenc...e map can support governments in making evidence-informed decisions about implementing programs to reduce AMR, by identifying, describing, and assessing the full range of evaluated government policy options to reduce antimicrobial use in humans. METHODS AND FINDINGS: Seven databases were searched from inception to January 28, 2019, (MEDLINE, CINAHL, EMBASE, PAIS Index, Cochrane Central Register of Controlled Trials, Web of Science, and PubMed). We identified studies that (1) clearly described a government policy intervention aimed at reducing human antimicrobial use, and (2) applied a quantitative design to measure the impact. We found 69 unique evaluations of government policy interventions carried out across 4 of the 6 WHO regions. These evaluations included randomized controlled trials (n = 4), non-randomized controlled trials (n = 3), controlled before-and-after designs (n = 7), interrupted time series designs (n = 25), uncontrolled before-and-after designs (n = 18), descriptive designs (n = 10), and cohort designs (n = 2). From these we identified 17 unique policy options for governments to reduce the human use of antimicrobials. Many studies evaluated public awareness campaigns (n = 17) and antimicrobial guidelines (n = 13); however, others offered different policy options such as professional regulation, restricted reimbursement, pay for performance, and prescription requirements. Identifying these policies can inform the development of future policies and evaluations in different contexts and health systems. Limitations of our study include the possible omission of unpublished initiatives, and that policies not evaluated with respect to antimicrobial use have not been captured in this review. CONCLUSIONS: To our knowledge this is the first study to provide policy makers with synthesized evidence on specific government policy interventions addressing AMR. In the future, governments should ensure that AMR policy interventions are evaluated using rigorous study designs and that study results are published. more

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Burden of disease from inadequate water, sanitation and hygiene for selected adverse health outcomes: An updated analysis with a focus on low- and middle-income countries

Prüss-Ustün A., Wolf J., Bartram J., et al. (2019) CC

Int J Hyg Environ Health. 2019 Jun; 222(5): 765–777. doi: 10.1016/j.ijheh.2019.05.004; To develop updated estimates in response to new exposure and exposure-response data of the burden of diarrhoea, respiratory infections, malnutrition, schistosomiasis, malaria, soil-transmitted helminth infec... more

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Global priorities for climate change and mental health research

Fiona Charlson, Suhailah Ali, Jura Augustinavicius et al. Environment International (2022) CC

Compared with other health areas, the mental health impacts of climate change have received less research attention. The literature on climate change and mental health is growing rapidly but is characterised by several limitations and research gaps. In a field where the need for designing evidence-b... more

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The Impact of Climate Change on Health: Reducing Risks and Increasing Resilience in the Era of COVID-19

Machalaba; C.; Bouley, T. A.; Nunziata, K. R.; et al. (2021) C1

The climate crisis has many consequences – among them widespread health impacts that will lead to immense societal, ecological, and economic harm. Over the past two decades multiple large-scale reviews on climate change and health have made clear the need for a multi-sectoral approach to target t... more

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Chapter 6 Green Spaces and Child Health and Development

Dadvand, P.; Gascon M., Markevych I. (2019) CC

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Education for sustainable healthcare: Leadership to get from here to there

McKimm J., Redvers N., El Omrani O., et al. (2020) C1

The current global crises, including climate, COVID-19, and environmental change, requires global collective action at all scales. These broad socio-ecological challenges require the engagement of diverse perspectives and ways of knowing and the meaningful engagement of all generations and stages of... more

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The Planetary Health Education Framework

Guzman C., Potter T. (2020) CC

The Planetary Health Education Framework is a project of the Planetary Health Alliance (planetaryhealthalliance.org). The Planetary Health Alliance is a consortium of over 250 partners from around the world committed to understanding and addressing the human health impacts of global environmental ch... more

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Pneumonia kit 2020

World Health Organization WHO (2020) C_WHO

For 100 cases among which 60 cases of children ≥ 5 years old and 40 cases of children < 5 years old and adults. The new Pneumonia kit 2020 is specially designed to provide sufficient child-size antibiotics to treat pneumonia, targeting children under 5 years of age. It aims to provide life-savi... more

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Investigation of the Quality of the 12 Most-Used Antibiotics Available in Retail Private Pharmacies in Rwanda

Bizimana, T.; Kagisha, V.; Nyandwi, J.B: et al. MDPI Antibiotics (2022) CC

Antibiotics 2022, 11(3), 329; https://doi.org/10.3390/antibiotics11030329. The authors found that the most-represented antibiotics on the Rwandan market were amoxicillin, co-trimoxazole and cloxacillin. No counterfeit antibiotics were found in this study. However, substandard batches with moderate ... more

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Tuberculosis services disrupted by war in Ukraine

Holt, E. (2022) C2

the Lancet Infectious Diseases Published online March 22, 2022 https://daoi.org/10.1016/S1473-3099(22)00214-6

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Code Red for Health response in Latin America and the Caribbean: Enhancing peoples' health through climate action

Yglesias_González; M.; et al. (2022) CC

The Lancet Regional Health - Americas 2022;00: 100248 Published online xxx https://doi.org/10.1016/j.lana.2022.100248. The Lancet Countdown report, discuss the overlapping social, climate and health challenges in Latin America and the Caribbean, and urge multisectoral and political action to trans... more

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Impact of climate change on global malaria distribution

Cyril Caminade, Sari Kovats, Joacim Rocklov et al. PNAS (2014) CC

PNAS | March 4, 2014 | vol. 111 | no. 9 Malaria is an important disease that has a global distribution and significant health burden. The spatial limits of its distribution and seasonal activity are sensitive to climate factors, as well as the local capacity to control the disease. Malaria is also ... more

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Primary Protection: Enhancing Health Care Resilience for a Changing Climate

Robin G. and J. Balbus (2014) CC

Best Practices Report.PART 1 Primary Protection: Enhancing Health Care Resilience for a Changing Climatei Primary Protection: EnhancingU.S. Department of Health and Human Services

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Spatiotemporal distribution of antimicrobial resistant organisms in different water environments in urban and rural settings of Bangladesh

Asaduzzaman, M. et al. (2022) CC

The authors conduct an integrated survey of Antimicrobial Resistant Organisms (AMR) in drinking water, wastewater and surface water in three settings in Bangladesh: rural households, rural poultry farms, and urban food markets. Results show that untreated water discharged from rural households, poul... more

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A Concrete Example of the One Health Approach in the Brazilian Unified Health System

Souza, P.C.A.; et al. (2021) CC

Front. Public Health, 04 June 2021 | https://doi.org/10.3389/fpubh.2021.618234

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The Berlin principles on one health – Bridging global health and conservation

Gruetzmacher, K.; et al. (2021) CC

Science of The Total Environment Volume 764, 10 April 2021, 142919

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One Health Core Competencies

One Health Commission (2019) CC

This compilation of publications focuses on Core Competencies needed for implementing a One Health approach.

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One Health Modules

Southeast Asia One Health University Network, et al. (2022) CC

14 One Health Modules: learning better respones to complex health problems

Harmonized health facililty assessment (HHFA)

World Health Organization WHO (2021) C_WHO

Combined questionnaire Core

Standard Treatment Guidelines and Essential Medicines List for South Africa : Primary Healthcare Level 2020 edition

the Essential Drugs Programme, the PHCAdult Hospital Level Expert review Committee, the National Essential Medicines List Committee National Department of Health South Africa (2020) CC

The PHC STGs and EML should be used by healthcare workers providing care at clinics, community health centres, and gateway clinics at hospitals. Pharmaceutical and Therapeutics Committees (PTCs) are responsible for ensuring the availability of medicines listed in the PHC EML at those facilities, as... more