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Therapeutics and COVID-19 (Living Guideline, 10 November 2023)

World Health Organization WHO (2023) C_WHO

WHO has updated its guidelines for COVID-19 therapeutics, with revised recommendations for patients with non-severe COVID-19. This is the 13th update to these guidelines. Updated risk rates for hospital admission in patients with non-severe COVID-19 The guidance includes updated risk rates for... hospital admission in patients with non-severe COVID-19. The current COVID-19 virus variants tend to cause less severe disease while immunity levels are higher due to vaccination, leading to lower risks of severe illness and death for most patients. This update includes new baseline risk estimates for hospital admission in patients with non-severe COVID-19. The new ‘moderate risk’ category now includes people previously considered to be high risk including older people and/or those with chronic conditions, disabilities, and comorbidities of chronic disease. The updated risk estimates will assist healthcare professionals to identify individuals at high, moderate or low risk of hospital admission, and to tailor treatment according to WHO guidelines: **High: **People who are immunosuppressed remain at higher risk if they contract COVID-19, with an estimated hospitalization rate of 6%. **Moderate: **People over 65 years old, those with conditions like obesity, diabetes and/or chronic conditions including chronic obstructive pulmonary disease, kidney or liver disease, cancer, people with disabilities and those with comorbidities of chronic disease are at moderate risk, with an estimated hospitalization rate of 3%. Low: Those who are not in the high or moderate risk categories are at low risk of hospitalization (0.5%). Most people are low risk. Review of COVID-19 treatments for people with non-severe COVID-19 WHO continues to strongly recommend nirmatrelvir-ritonavir (also known by its brand name ‘Paxlovid’) for people at high-risk and moderate risk of hospitalization. The recommendations state that nirmatrelvir-ritonavir is considered the best choice for most eligible patients, given its therapeutic benefits, ease of administration and fewer concerns about potential harms. Nirmatrelvir-ritonavir was first recommended by WHO in April 2022. If nirmatrelvir-ritonavir is not available to patients at high-risk of hospitalization, WHO suggests the use of molnupiravir or remdesivir instead. WHO suggests against the use of molnupiravir and remdesivir for patients at moderate risk, judging the potential harms to outweigh the limited benefits in patients at moderate risk of hospital admission. For people at low risk of hospitalization, WHO does not recommend any antiviral therapy. Symptoms like fever and pain can continue to be managed with analgesics like paracetamol. WHO also recommends against use of a new antiviral (VV116) for patients, except in clinical trials. The update also includes a strong recommendation against the use of ivermectin for patients with non-severe COVID-19. WHO continues to advise that in patients with severe or critical COVID-19, ivermectin should only be used in clinical trials. more

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Laboratory manual for yellow fever
recommended

World Health Organization WHO (2024) C_WHO

This WHO laboratory manual provides the most up to date methods and procedures for the laboratory identification of yellow fever virus infection in humans. It provides guidance on the establishment and maintenance of an effective laboratory providing routine surveillance testing for yellow fever, wh... more

Training Guide: Mental Health and Psychosocial Support in Emergencies

International Federation of Red Cross and Red Crescent Societies IFRC (2024) CC

This MHPSS in Emergencies training aims to prepare MHPSS responders, disaster managers, and emergency team leaders for work in the field by building understanding of basic concepts of MHPSS in emergencies as well as planning and implementing PSS activities. It is for MHPSS focal points from the Red ... more

Access to NCD medicines: emergent issues during the COVID-19 pandemic and key structural factors 2023

World Health Organization WHO (2023) C_WHO

The coronavirus disease (COVID-19) pandemic exacerbated pre-existing inequalities in the treatment and care of noncommunicable diseases (NCDs). This report examines the effect of the COVID-19 pandemic on access to NCD medicines, and the policies and strategies implemented by countries and health sys... more

Asia Pacific Health Security Action Framework

World Health Organization WHO (2024) C_WHO

Public health emergencies, including pandemics, highlight the need for health systems and services that are prepared, resilient and ready to respond to health security threats. Endorsed by Member States in 2023, the Asia Pacific Health Security Action Framework (‎APHSAF)‎ is designed to engage m... more

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Africa CDC Reproductive Health | Strategic Priorities 2022-2026

Centers for Disease Control and Prevention (CDC) (2023) CC

In 2006, the Special Session of African Union Health Ministers adopted the Maputo Plan of Action for implementing the Continental Policy Framework on sexual and reproductive health and rights (SRHR), which expired at the end of 2015. The goal was for all stakeholders and partners to join forces and ... more

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Consolidated Ebola Virus Disease Preparedness Checklist. Revision 1
recommended

World Health Organization (2015)

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Humanitarian Assistance In Disaster Situations

PAHOWorld Health Organization (1999) C_WHO

A guide for effective aid

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Clinic Supervisor Manual

Management Sciences for Health; USAID (2006) C1

This Clinic Supervisor’s Manual is helpful for focusing managers on the key elements of integrated primary health care as they simultaneously integrate new interventions for HIV/AIDS, tuberculosis, and malaria. This tool contains 12 sections. Section 1 explains how to use the manual. Section 2 hel... more

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Logistics

R.S. Stephenson WHO; UNDP (1993)

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Indicators and Reference Data: A Practical Tool for Project Managers in Humanitarian Aid

Marie Theres Benner and K. Peter Schmitz Malteser International (2011)

Operational Guideline

The Interagency Emergency Health Kit 2017
recommended

World Health Organization WHO; UNICEF; ICRC; et al. (2019) C_WHO

Interagency Guidelines; Medicines and medical devices for 10 000 people for approximately three month.

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HIV and TB in Practice for nurses: Drug-resistant TB

Lesley Odendal (2013) CC

HIV & AIDS Treatment in Practice No.202

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Guidelines for treatment of tuberculosis

World Health Organization (2010) C_WHO

4th edition. This is fourth edition of Treatment of tuberculosis: guidelines, adhering fully to the new WHO process for evidence-based guidelines. Several important recommendations are being promoted in this new edition

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Practical Guidelines for Infection Control in Health Care Facilities
recommended

Manju Vatsa, Duangvadee Sungkhobol, Sudarshan Kumari, et al. WHO Western Pacific, Manila, and WHO South-East Asia, New Delhi (2004)

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The Role of Laboratories and Blood Banks in Disaster Situations

Pan American Health Organization (2001) C_WHO

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Dermatological Preparations For The Tropics
recommended

Peter Bakker; Herman Woerdenbag; Vincent Gooskens; Ben Naafs, et al. (2012) C_WHO

A formulary of dermatological preparations and background information on therapeutic choices, production and dispensing. 2nd edition

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Sanitation In Emergencies

WHO (2015)

excreta disposal in emergencies

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Essentials For Emergencies

World Health Organization (2004) C_WHO

The purpose of this booklet is to assist WHO and other Public Health workers in the field when an emergency occurs. The booklet provides technical hints on how to carry out a rapid health assessment, how to facilitate coordination, how departments in WHO can assist, etc. Standard formats for re... more