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Solidarity” is an international clinical trial to help find an effective treatment for COVID-19, launched by the World Health Organization and partners. The Solidarity Trial will compare four treatment options against standard of care, to assess their relative effectiveness against COVID-19. By ... more

Cognitive and psychosocial interventions

World Health Organization (2012) C_WHO
Q5: For people with dementia, which cognitive/psychosocial interventions (such as cognitive stimulation, cognitive rehabilitation, reality orientation, reminiscence therapy) when compared to placebo/comparator produce benefits/harm in the specified outcomes?
Information note
It is intended for use among clinicians taking care of moderate to severe COVID-19 cases. The COVID-19 outbreak has brought with it the need for improved critical care for patients who develop severe disease. The majority of COVID-19 patients present with mild to moderate illness, 15% develop sever ... more
Vaccination programmes against COVID-19 and seasonal influenza are currently being implemented in parallel in many countries. Administration of both vaccines during the same visit has potential advantages. This document presents the evidence related to coadministration of Covid-19 and influenza vacc ... more
DHS Working Papers No. 105 - Rwanda has developed and implemented many strategies at the national level to reduce the incidence of HIV in the general population. One of the main objectives of such interventions is to improve the general level of knowledge of HIV, with the hypothesis that increasing ... more
Q2: In individuals with psychotic disorders (including schizophrenia), is the use of two or more antipsychotic medications concurrently more effective and safer than the use of one antipsychotic only?
Q7: In individuals with bipolar mania, are a) antipsychotics, b) mood stabilizers (lithium carbonate, valproate, and carbamazepine) effective and safe

WHO mhGAP Guideline update

WHO WHO (2015) C_WHO
Update of the Mental Health Gap Action Programme (mhGAP) Guideline for Mental, Neurological and Substance use Disorders May 2015

Treatment of psychostimulant dependence

World Health Organization (2012) C_WHO
Q3: Are pharmacotherapies safe and effective for the treatment of psychostimulant dependence (maintenance or relapse prevention) in non-specialized settings?
(New 2015) Scoping question: In school students aged 14-­‐‑15 years, are school-­‐‑based interventions effective in reducing deaths from suicide and suicide attempts compared to care-­‐‑as-­‐‑usual?
Gambiense human African trypanosomiasis is a deadly infectious disease affecting West and Central Africa, South Sudan and Uganda, and transmitted between humans by tsetse flies. The disease has caused several major epidemics, the latest one in the 1990s. Thanks to recent innovations such as rapid di ... more
Настоящая брошюра посвящена организации наркологической помощи женщинам с учетом их особых потребностей. Она подготовлена в рамках проекта Управления Организац ... more
This document contains: The systematic reviews and GRADE assessments used at the Index-TB Guideline Panel in July 2015; The Evidence to Decision tables that record the Panel’s assessment and recommendations from this meeting
Q10: In individuals with psychotic disorders (including schizophrenia) and bipolar disorders are psychoeducation, family interventions and cognitive-behavioural therapy feasible and effective?

Role of Memantine

World Health Organization (2012) C_WHO
Q2: For people with dementia, does memantine, when compared to placebo/comparator, produce benefits/harm in the specified outcomes in non-specialist health settings?

Antiepileptic drug treatment after first unprovoked seizure

World Health Organization (2012) C_WHO
Q8. Should Anti-Epileptic Drug (AED) treatment be started after first unprovoked seizure in non-specialist health settings?
SCOPING QUESTION: For adults and children with medication-resistant convulsive epilepsy, which anti-epileptic medications produce benefits and/or harm in the specified outcomes when compared to a placebo or a comparator?

Behaviour change techniques for promoting mental health

World Health Organization (2012) C_WHO
Q13: What is the effectiveness of behaviour change techniques including life skills education in promoting mental health for children and adolescents?