The Information, education and communication (IEC) activities, with the development of contextualized activities for various actors and scenarios about preventative measures and surveillance tools, are essential to increase awareness, reduce biomedical and psychosocial barriers to accessing diagnosi...s and care; keep the maximum number of actors involved; and reach the affected population, including family, friends and society in general.
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This statistical overview has been prepared on the occasion of the European Institute for
Gender Equality (EIGE) study on FGM in the European Union and Croatia. Little is known
about FGM in the European Union in general, and this statement holds true about FGM
and asylum more specifically. In lig...ht of the recognized need for country- and community-
tailored responses, this study provides some of the statistical evidence needed to
advance the discussion on the necessary policies and tools to address the specific
vulnerabilities of female asylum-seekers with FGM in the asylum system on the one hand,
and of refugee girls and women living with FGM and integrating in EU Member States on
the other hand
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Leishmaniasis is a vector-borne disease with a wide variety of parasite species, reservoirs, and vectors involved in transmission. It is caused by different species of the protozoa Leishmania and is transmitted to animals and humans through a bite of insects in the Psychodidae family. Its presence i...s directly linked to poverty, but social, environmental, and climatalogic factors directly influence the disease's epidemiology.
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Since 2000, concerted efforts by national programmes, supported by public–private partnerships, nongovernmental organizations, donors and academia under the auspices and coordination of the World Health Organization (WHO), have produced important achievements in the control of human African trypan...osomiasis (HAT). As a consequence, the disease was targeted for elimination as a public health problem by 2020. The Sixty-sixth World Health Assembly endorsed this goal in resolution WHA66.12 on neglected tropical diseases, adopted in 2013.
National sleeping sickness control programmes (NSSCPs) are core to progressing control of the disease and in adapting to the different epidemiological situations. The involvement of different partners, as well as the support and trust of long-term donors, has been crucial for the achievements.
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The twentieth century ended with human African trypanosomiasis (HAT) epidemics raging across many parts of Africa. Resistance to existing drugs was emerging, and many programs aiming to contain the disease had ground to a halt, given previous success against HAT and the competing priorities associat...ed with other medical crises ravaging the continent. A series of dedicated interventions and the introduction of innovative routes to develop drugs, involving Product Development Partnerships, has led to a dramatic turnaround in the fight against HAT caused by Trypanosoma brucei gambiense. The World Health Organization have been able to optimize the use of existing tools to monitor and intervene in the disease. A promising new oral medication for stage 1 HAT, pafuramidine maleate, ultimately failed due to unforeseen toxicity issues. However, the clinical trials for this compound demonstrated the possibility of conducting such trials in the resource-poor settings of rural Africa.
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Treatment of second-stage gambiense human African trypanosomiasis relied on toxicarsenic-based derivatives for over 50 years. The availability and subsequent use of eflornithine,initially in monotherapy and more recently in combination with nifurtimox (NECT), has drasticallyimproved the pro...gnosis of treated patients. However, NECT logistic and nursing requirementsremain obstacles to its deployment and use in peripheral health structures in rural sub-SaharanAfrica. Two oral compounds, fexinidazole and SCYX-7158, are currently in clinical development.The main scope of this article is to discuss the potential impact of new oral therapies to improvediagnosis-treatment algorithms and patients’access to treatment, and to contribute to reach theobjectives of the recently launched gambiense humanAfrican trypanosomiasis elimination program
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Information for the General Public
Epidemiological Update
Dengue
7 February 2020
Situation summary
In the Region of the Americas, between epidemiological week (EW) 1 and EW 521 of 2019, a total of 3,139,335 cases of dengue have been reported (321.58 cases per 100,000 population), including 1,538 deaths. Of the total cases, 1,367,...353 (43.6%) were laboratory-confirmed and 28,169 (0.9%) were classified as severe dengue. The case-fatality rate was 0.049%.
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After 100 years of chemotherapy with impractical and toxic drugs, an oral cure for human African trypanosomiasis (HAT) is available: Fexinidazole. In this case, we review the history of drug discovery for HAT with special emphasis on the discovery, pre-clinical development, and operational challenge...s of the clinical trials of fexinidazole. The screening of the Drugs for Neglected Diseases initiative (DNDi) HAT-library by the Swiss TPH had singled out fexinidazole, originally developed by Hoechst (now Sanofi), as the most promising of a series of over 800 nitroimidazoles and related molecules. In cell culture, fexinidazole has an IC50 of around 1 µM against Trypanosoma brucei and is more than 100-fold less toxic to mammalian cells. In the mouse model, fexinidazole cures both the first, haemolymphatic, and the second, meningoencephalitic stage of the infection, the latter at 100 mg/kg twice daily for 5 days. In patients, the clinical trials managed by DNDi and supported by Swiss TPH mainly conducted in the Democratic Republic of the Congo demonstrated that oral fexinidazole is safe and effective for use against first- and early second-stage sleeping sickness. Based on the positive opinion issued by the European Medicines Agency in 2018, the WHO has released new interim guidelines for the treatment of HAT including fexinidazole as the new therapy for first-stage and non-severe second-stage sleeping sickness caused by Trypanosoma brucei gambiense (gHAT). This greatly facilitates the diagnosis and treatment algorithm for gHAT, increasing the attainable coverage and paving the way towards the envisaged goal of zero transmission by 2030.
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Chagas disease, or American trypanosomiasis, is a condition that causes gradual organ damage. Without treatment, it can be fatal.
This article explains where the T. cruzi parasite is most common and how it can spread. It also outlines the symptoms of Chagas disease and the treatment options avail...able.
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The Strategy aims to protect and improve the well-being
of society and of the individual, to protect and promote
public health, to offer a high level of security and well-being
for the general public and to increase health literacy. The
Strategy takes an evidence-based, integrated, balanced and
...
multidisciplinary approach to the drugs phenomenon at
national, EU and international level. It also incorporates a
gender equality and health equity perspective.
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Esta hoja informativa destaca la relación entre el consumo de alcohol y la COVID-19. El alcohol se utiliza a menudo para la socialización y por algunas personas para hacer frente a las emociones difíciles como la ansiedad, el miedo, la depresión, el aburrimiento y la incertidumbre, todo lo cual ...aumentó durante la pandemia de COVID-19, con el consiguiente incremento en el consumo de alcohol, especialmente en quienes ya bebían en exceso.
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This fact sheet highlights the relationship between alcohol consumption and COVID-19. Heavy episodic drinking is considered a health risk for COVID-19, and alcohol is used by some to cope with difficult emotions that increased during the pandemic.
PAHO Core Indicators provide the latest data on health indicators for the Region of the Americas, a few of which may be explored in the visualization below. This dataset is composed of about 200 health and health related indicators from 1995 to 2021 for 49 countries and territories in the Region of ...the Americas.
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Los indicadores básicos de la OPS proporcionan los datos más recientes sobre indicadores de salud para la Región de las Américas, tales como los ejemplos que se muestran abajo. Este conjunto de datos se compone de cerca de 200 indicadores de salud y relacionados con la salud de 1995 a 2021 para ...49 países y territorios de la Región de las Américas.
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Latin America and the Caribbean is characterized by a matrix of social inequality whose axes —such as
socioeconomic stratum, gender, stage in the life cycle, ethnicity and race, territory, disability, and immigration
status— create multiple, often concurrent, situations of exclusion and discri...mination. The coronavirus
disease (COVID-19) pandemic has exacerbated wide social gaps and it is no coincidence that Latin America
and the Caribbean is one of the regions in which the health and socioeconomic impacts of the pandemic have
been the most severe, which shows that the costs of inequality are unsustainable
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Suicide mortality in the Region of the Americas. Regional Report 2015-2019
Este informe, que se publica cada cinco años. brinda datos actualizados sobre el suicidio en la Región de las Américas. Esta cuarta edición, además de incluir análisis similares a los realizados previamente (suicidio p...or edad, sexo y métodos utilizados), utiliza técnicas de estadística descriptiva para caracterizar cuantitativamente la mortalidad por suicidio y su distribución por grupo etario y sexo, así como los años de vida perdidos, por país, subregión y región, para el período 2015-2019.
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A global food crisis fuelled by conflict, climate shocks and the COVID-19 pandemic is growing because of the ripple effects of the war in Ukraine driving rising prices of food, fuel and fertilizer. Millions of people across the world are at risk of being driven into starvation unless action is taken... now to respond together and at scale. Due to the unprecedented overlap of crises, WFP’s annual operational requirements are at an all-time high of US$22.2 billion, with confirmed contributions so far at US$4.8 billion (22 percent). WFP is calling for coordinated action to address this crisis.
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Diabetes is a major public health problem in the Americas and worldwide, demanding special attention and integrated response. It is estimated that more than 62 million adults are living with diabetes in the Americas. The projections show that diabetes prevalence will continue to increase to at least... 2025. Its steady rise has been mainly due to the high prevalence of risk factors, especially overweight/obesity and physical inactivity. Diabetes also is one of the leading causes of mortality and disability worldwide and across our Region.
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