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Mpox Testing Strategy - November 2024

Africa Center for Disease Control and Prevention (2024) CC

Mpox is an emerging zoonotic disease caused by the mpox virus, a member of the Orthopoxvirus genus closely related to the variola virus that causes smallpox. Mpox was first discovered in 1958 when outbreaks of a pox-like disease occurred in monkeys kept for research. The first human case was recorde...d in 1970 in the Democratic Republic of the Congo (DRC) during a period of intensified effort to eliminate smallpox and since then the infection has been reported in a number of African countries. Mpox can spread in humans through close contact, usually skin-to-skin contact, including sexual contact, with an infected person or animal, as well as with materials contaminated with the virus such as clothing, beddings and towels, and respiratory droplets in prolonged face to face contact. People remain infectious from the onset of symptoms until all the lesions have scabbed and healed. The virus may spread from infected animals through handling infected meat or through bites or scratches. Diagnosis is confirmed by polymerase chain reaction (PCR) testing of material from a lesion for the virus’s DNA. Two separate clades of the mpox virus are currently circulating in Africa: Clade I, which includes subclades Ia and Ib, and Clade II, comprising subclades IIa and IIb. Clade Ia and Clade Ib have been associated with ongoing human-to-human transmission and are presently responsible for outbreaks in the Democratic Republic of the Congo (DRC), while Clade Ib is also contributing to outbreaks in Burundi and other countries. In 2022‒2023 mpox caused a global outbreak in over 110 countries, most of which had no previous history of the disease, primarily driven by human-to-human transmission of clade II through sexual contact. In just over a year, over 90,000 cases and 150 deaths were reported to the WHO. For the second time since 2022, mpox has been declared a global health emergency as the virus spreads rapidly across the African continent. On 13 Aug 2024, Africa CDC declared the ongoing mpox outbreak a Public Health Emergency of Continental Security (PHECS), marking the first such declaration by the agency since its inception in 2017.7 This declaration empowered the Africa CDC to lead and coordinate responses to the mpox outbreak across affected African countries. On August 14, 2024, the WHO declared the resurgence of mpox a Public Health Emergency of International Concern (PHEIC) emphasizing the need for coordinated international response. As of August 2024, Mpox has expanded beyond its traditional endemic regions, with new cases reported in countries including Sweden, Thailand, the Philippines, and Pakistan. Sweden has confirmed its first case of Clade 1 variant, which has been rapidly spreading in Africa, particularly in DRC. The emergence of this new variant raises concerns about its potential for higher lethality and transmission rates outside Africa. more

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Indicators for assessing infant and young child feeding practices/Part 1

WHO (2008)

Part 1 Definitions

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Guidelines for the Management of Snake-bites. 2nd edition
recommended

Word Health Organization Regional Office of South-East Asia Word Health Organization Regional Office of South-East Asia (2016) C_WHO

Snakebites are well-known medical emergencies in many parts of the world, especially in rural areas. Agricultural workers and children are the most affected. The incidence of snakebite mortality is particularly high in South-East Asia. Rational use of snake anti-venom can substantially reduce mortal... more

Basic Eye Care
recommended

Helen Keller International (1996)

Training Activities for Community Health Workers

WHO recommendations on postnatal care of the mother and newborn

World Health Organization (2013) CC

The guidelines address timing, number and place of postnatal contacts, and content of postnatal care for all mothers and babies during the six weeks after birth. The primary audience for these guidelines is health professionals who are responsible for providing postnatal care to women and newborns, ... more

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Revised WHO classification and treatment of childhood pneumonia at health facilities

World Health Organization (2014)

The revised guidelines present two major changes to existing guidelines: (A) there are now just 2 categories of pneumonia instead of 3 (“pneumonia” which is treated at home with oral amoxicillin and “severe pneumonia” which requires injectable antibiotics) and (B) oral amoxicillin replaces o... more

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Namibia 2012/13 Health Accounts Report

Ministry of Health and Social Services, Windhoek, Namibia (2015) C1

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Country Profile on Disability Ethiopia

The World Bank (2002) C1

Namibia: Guidelines on mobile orthopaedic technical services

Ministry of Health and Social Services (MOHSS) (2014) C1

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Nutrition Policy and Programs in Ghana

A.B. Ghartey The World Bank, et al. (2010) C1

The limitation of a single sector approach. HNP Discussion Paper

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Uganda: Integrated Community Case Management of Childhood Malaria, Pneumonia and Diarrhoea - Implementation Guidelines

World Health Organization WHO; UNICEF; Ministry of Health Uganda (2010) C_WHO

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Guía de intervención humanitaria mhGAP (GIH-mhGAP) - El manejo clínico de los trastornos mentales, neurológicos y por uso de sustancias en las emergencias humanitarias
recommended

World Health Organization, UN High Commissioner for Refugees (2015) C_WHO

La Guía de intervención humanitaria mhGAP es una herramienta sencilla y práctica destinada a ayudar a los servicios de salud generales en contextos de emergencias humanitarias, a detectar y tratar los trastornos mentales, neurológicos y por uso de sustancias psicoactivas. Se trata de una adapta... more

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Kenya reproduvtive, newborn, child and adolescent health (RMNCAH) Investment framework

Ministry of Health, Government of Kenya (2016) C2

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The Well-Being of Children with Disabilities in the Asia Pacific Region

Gwynnyth Llewellyn, Eric Emerson, Ros Madden and Anne Honey The University of Sydney (2012) C2

AN ANALYSIS OF UNICEF MICS 3 SURVEY DATA FROM BANGLADESH, LAO PDR, MONGOLIA AND THAILAND

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Module 13: Developmental monitoring and screening

United Nations Children's Fund (UNICEF) & International STEP by STEP Association (2016)

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Guidelines on Mental Health and Psychosocial Support

Internationl Committee of the Red Cross ICRC (2018) C1

These ICRC guidelines outline the organization’s approach to mental health and psychosocial support (MHPSS) during and after armed conflict and other situations of violence. They provide a framework for harmonizing MHPSS programmes within the organization, and an insight into its strategic process... more

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Disability at a Glance 2015: STRENGTHENING EMPLOYMENT PROSPECTS FOR DISABILITY AT A GLANCE 2015 PERSONS WITH DISABILITIES IN ASIA AND THE PACIFIC

United Nations ESCAP (2015) C1

Disability at a Glance 2015 focuses on barriers to the employment of persons with disabilities in the Asia-Pacific region, and offers solutions to strengthen their employment prospects. Employment is not only the primary means of livelihood generation; it also provides individuals with the purpose a... more

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Key political commitment documents for tuberculosis prevention and care and their intended influence in the WHO European Region

World Health Organization WHO, Regional Office for Europe (2019) C_WHO

This analytical report reviews and discusses the potential role and influence of political commitment in implementing endorsements and conducting policy in the field of tuberculosis (TB) prevention and care. It promotes discussion by comparing and analysing the extent to which selected international... more