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Mpox Testing Strategy - November 2024

Africa Center for Disease Control and Prevention (2024) CC

Mpox is an emerging zoonotic disease caused by the mpox virus, a member of the Orthopoxvirus genus closely related to the variola virus that causes smallpox. Mpox was first discovered in 1958 when outbreaks of a pox-like disease occurred in monkeys kept for research. The first human case was recorde...d in 1970 in the Democratic Republic of the Congo (DRC) during a period of intensified effort to eliminate smallpox and since then the infection has been reported in a number of African countries. Mpox can spread in humans through close contact, usually skin-to-skin contact, including sexual contact, with an infected person or animal, as well as with materials contaminated with the virus such as clothing, beddings and towels, and respiratory droplets in prolonged face to face contact. People remain infectious from the onset of symptoms until all the lesions have scabbed and healed. The virus may spread from infected animals through handling infected meat or through bites or scratches. Diagnosis is confirmed by polymerase chain reaction (PCR) testing of material from a lesion for the virus’s DNA. Two separate clades of the mpox virus are currently circulating in Africa: Clade I, which includes subclades Ia and Ib, and Clade II, comprising subclades IIa and IIb. Clade Ia and Clade Ib have been associated with ongoing human-to-human transmission and are presently responsible for outbreaks in the Democratic Republic of the Congo (DRC), while Clade Ib is also contributing to outbreaks in Burundi and other countries. In 2022‒2023 mpox caused a global outbreak in over 110 countries, most of which had no previous history of the disease, primarily driven by human-to-human transmission of clade II through sexual contact. In just over a year, over 90,000 cases and 150 deaths were reported to the WHO. For the second time since 2022, mpox has been declared a global health emergency as the virus spreads rapidly across the African continent. On 13 Aug 2024, Africa CDC declared the ongoing mpox outbreak a Public Health Emergency of Continental Security (PHECS), marking the first such declaration by the agency since its inception in 2017.7 This declaration empowered the Africa CDC to lead and coordinate responses to the mpox outbreak across affected African countries. On August 14, 2024, the WHO declared the resurgence of mpox a Public Health Emergency of International Concern (PHEIC) emphasizing the need for coordinated international response. As of August 2024, Mpox has expanded beyond its traditional endemic regions, with new cases reported in countries including Sweden, Thailand, the Philippines, and Pakistan. Sweden has confirmed its first case of Clade 1 variant, which has been rapidly spreading in Africa, particularly in DRC. The emergence of this new variant raises concerns about its potential for higher lethality and transmission rates outside Africa. more

Preventing HIV misdiagnosis: implementation guide

World Health Organization WHO (2024) CC

HIV testing programmes need to ensure that all clients who test for HIV are provided with correct diagnoses. The accuracy of HIV testing is critical to prevent misdiagnosis, as the consequences of giving an incorrect test result can be serious for clients, HIV testing services, HIV programmes and pu... more

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Neonatal Tetanus Elimination Field Guide

Pan American Health Organisation PAHO (2005) C_WHO

In many countries neonatal tetanus is responsible for half of all neonatal deaths due to vaccine-preventable diseases and for almost 14% of al¡ infant deaths. It is estimated that in the 1970s more than 10,000 newborns died annually from neonatal tetanus in the Americas. Neonatal tetanus is prevent... more

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The Treatment of Diarrhoea

World Health Organization WHO (2005) C_WHO

A manual for physicians and other senior health workers. This fourth revision of the manual reflects recent clinical experience and research findings in diarrhoea case management. Compared to earlier versions, it includes revised guidelines on the management of children with acute diarrhoea using th... more

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Refugee Health
recommended

Médecins sans Frontières (1997) C3

An approach to emergency situations. Relief workers face rapidly changing and complex environments, new disease patterns, enormous humanitarian needs and relatively limited resources. The authors of this book use their experience in the area to produce an operational manual of the issues involved in... more

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An Introduction to Evaluation of Humanitarian Action. Course Manual

Margie Buchanan-Smith and John Telford Channel Research; ALNAP (2006)

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Climate Information For Public Health: A Curriculum For Best Practices

Laurence Cibrelus; Gilma Mantilla International Research Institute for Climate and Society (2011) C1

CIPH Curriculum for Best Practices. Putting Principles to Work

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Minimum Standards in Shelter, Settlement and Non-Food Items
recommended

The Sphere Project (2016) C1

Links to the Humanitarian Charter and international law

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Oxfam's Approach to Nutrition Surveys in Emergencies

Susanne Jaspars and Hisham Khogali Oxfam (2001) C1

Nutrition Surveys

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Tuberculosis. Practical guide for clinicians, nurses, laboratory technicians and medical auxiliaries

Médecins sans Frontières MSF (2022) C2

This Tuberculosis guide has been developed jointly by Médecins Sans Frontières and Partners In Health. It aims at providing useful information to the clinicians and health staff for the comprehensive management of tuberculosis. Forms of susceptible and resistant tuberculosis, tuberculosis in child... more

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Developing Pharmacy Practice - A focus on patient care

Wiedenmayer, K. et al. World Health Organization (WHO), International Pharmaceutical Federation (FIP) (2006) C_WHO

English version - This handbook sets out a the new paradigm for pharmacy practice. Its aim is to guide pharmacy educators in pharmacy practice, to educate pharmacy students and to guide pharmacists in practice to update their skills. The handbook, which brings together practical tools and knowledge,... more

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WHO Monographs On Selected Medicinal Plants - Volume 2

World Health Organization WHO (2007) C_WHO

• provide scientific information on the safety, efficacy, and quality control/ quality assurance of widely used medicinal plants, in order to facilitate their appropriate use in Member States; • provide models to assist Member States in developing their own mono- graphs or formularies for these... more

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Caring for Newborns and Children in the Community. Manual for the Community Health Worker

World Health Organization; UNICEF (2011) C_WHO

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Technical Updates of the guidelines on the Integrated Management of Childhood Illness (IMCI)

World Health Organization (2005)

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Dengue, Dengue Haemorrhagic Fever and Dengue Shock Syndrome in the Context of the Integrated Management of Childhood Illness

World Health Organization (2005) C_WHO

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Epilepsy Management At Primary Health Level In Rural China

World Health Organization WHO (2009) C_WHO

A Global Campaign Against Epilepsy Demonstration Project

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Bad Bug Book

Food and Drug Administration (FDA) (2013)

Handbook of Foodborne Pathogenic Microorganisms and Natural Toxins

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Infection Control for Viral Haemorraghic Fever in the African Health Care Setting

Centers for Disease Control and Prevention , World Health Organization WHO (1998)

Important Guideline for Ebola prevention and control It is designed for the following uses: - for prevention through preparedness--to help African health facilities make advance preparations for responding with appropriate precautions when a VHF (including Ebola) case is suspected. - for pl... more

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Kenya : Management of Severe Malaria
recommended

World Health Organization WHO (2012) C_WHO

This Handbook, an updated edition of the Management of Severe Malaria, provides new and revised practical guidance on the diagnosis and management of severe malaria.

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Consolidated guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection
recommended

World Health Organization WHO (2016) C_WHO

2nd edition. These guidelines provide guidance on the diagnosis of human immunodeficiency virus (HIV) infection, the use of antiretroviral (ARV) drugs for treating and preventing HIV infection and the care of people living with HIV. They are structured along the continuum of HIV testing, prevention,... more

Refugee Health recommended

Minimum Standards in Shelter, Settlement and Non-Food Items recommended

Kenya : Management of Severe Malaria recommended

Consolidated guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection recommended

Refugee Health
recommended

Minimum Standards in Shelter, Settlement and Non-Food Items
recommended

Kenya : Management of Severe Malaria
recommended

Consolidated guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection
recommended