Website last accessed on 24.03.2023
A parasite is an organism that lives on or in a host and gets its food from or at the expense of its host. Parasites can cause disease in humans.
Website last accessed in 24.03.2023
CDC provides continuing education for professionals involved in rabies prevention and control. While CDC provides some resources directly, others are offered through partnerships and collaborations with other public health entities. This page contains a collec
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tion of course notifications, education materials, and continuing education courses related to rabies prevention and control.
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Chagas heart disease (CHD) affects approximately 30% of patients chronically infected with the protozoa Trypanosoma cruzi. CHD is classified into four stages of increasing severity according to electrocardiographic, echocardiographic, and clinical criteria. CHD presents with a myriad of clinical man
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ifestations, but its main complications are sudden cardiac death, heart failure, and stroke. Importantly, CHD has a higher incidence of sudden cardiac death and stroke than most other cardiopathies, and patients with CHD complicated by heart failure have a higher mortality than patients with heart failure caused by other etiologies. Among patients with CHD, approximately 90% of deaths can be attributed to complications of Chagas disease. Sudden cardiac death is the most common cause of death (55%-60%), followed by heart failure (25%-30%) and stroke (10%-15%). The high morbimortality and the unique characteristics of CHD demand an individualized approach according to the stage of the disease and associated complications the patient presents with. Therefore, the management of CHD is challenging, and in this review, we present the most updated available data to help clinicians and cardiologists in the care of these patients. We describe the clinical manifestations, diagnosis and classification criteria, risk stratification, and approach to the different clinical aspects of CHD using diagnostic tools and pharmacological and non-pharmacological treatments.
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Background: The human helminth infections include ascariasis, trichuriasis, hookworm infections, schistosomiasis, lymphatic filariasis (LF) and onchocerciasis. It is estimated that almost 2 billion people worldwide are infected with helminths. Whilst the WHO treatment guidelines for helminth infecti
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ons are mostly aimed at controlling morbidity, there has been a recent shift with some countries moving towards goals of disease elimination through mass drug administration, especially for LF and onchocerciasis. However, as prevalence is driven lower, treating entire populations may no longer be the most efficient or cost-effective strategy. Instead, it may be beneficial to identify individuals or demographic groups who are persistently infected, often termed as being “predisposed” to infection, and target treatment at them.
Methods: The authors searched Embase, MEDLINE, Global Health, and Web of Science for all English language, humanbased papers investigating predisposition to helminth infections published up to October 31st, 2017. The varying definitions used to describe predisposition, and the statistical tests used to determine its presence, are summarised. Evidence for predisposition is presented, stratified by helminth species, and risk factors for predisposition to infection are identified and discussed.
Results: In total, 43 papers were identified, summarising results from 34 different studies in 23 countries. Consistent evidence of predisposition to infection with certain species of human helminth was identified. Children were regularly found to experience greater predisposition to Ascaris lumbricoides, Schistosoma mansoni and S. haematobium than adults. Females were found to be more predisposed to A. lumbricoides infection than were males. Household clustering of infection was identified for A. lumbricoides, T. trichiura and S. japonicum. Ascaris lumbricoides and T. trichiura also showed evidence of familial predisposition. Whilst strong evidence for predisposition to hookworm infection was identified, findings with regards to which groups were affected were considerably more varied than for other helminth species.
Conclusion: This review has found consistent evidence of predisposition to heavy (and light) infection for certain human helminth species. However, further research is needed to identify reasons for the reported differences between demographic groups. Molecular epidemiological methods associated with whole genome sequencing to determine ‘who infects whom’ may shed more light on the factors generating predisposition.
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Website last accessed on 04.04.2023
A step-by-step guide for teachers on how to conduct a school deworming day!
Accessed on 04.04.2023
The Drugs for Neglected Diseases initiative (DNDi) is an international
non-profit organization that discovers, develops, and delivers safe,
effective, and affordable treatments for the most neglected patients
Die Initiative Medikamente gegen vernachlässigte Krankheiten (Drugs for Neglected Diseases initiative, DNDi) ist eine internationale gemeinnützige Organisation, die sichere, wirksame und bezahlbare Behandlungen für die am meisten vernachlässigten Patient:innen erforscht, entwickelt und bereitste
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llt.
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La Iniciativa Medicamentos para Enfermedades Olvidadas (DNDi) es una organización internacional sin fines de lucro que proporciona tratamientos seguros, eficaces y asequibles para los pacientes más desatendidos, desde el laboratorio hasta su llegada a las manos de las poblaciones más vulnerables
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del mundo.
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L’initiative Médicaments contre les Maladies Négligées (DNDi) est une organisation internationale à but non lucratif spécialisée dans la recherche, le développement et la mise à disposition de traitements sûrs, efficaces et abordables aux patients les plus négligés.
A Iniciativa Medicamentos para Doenças Negligenciadas (DNDi) é uma organização internacional sem fins lucrativos que disponibiliza medicamentos seguros, eficazes e acessíveis para doenças negligenciadas, desde o laboratório até sua chegada às mãos das populações mais vulneráveis do mund
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o.
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Website last accessed on 09.04.2023
Human echinococcosis is a parasitic disease caused by tapeworms of the genus Echinococcus. More than one million people are affected by echinococcosis.
Website last accessed on 09.04.2023
La equinococosis humana es una enfermedad parasitaria causada por tenias del género Echinococcus. La equinococosis afecta a más de un millón de personas.
Skin-related neglected tropical diseases, or “skin NTDs”, are historically neglected because active case detection, individual case management, significant resources and intensive effort are required to control, eliminate and eradicate them. Integrated control and management of skin NTDs offers
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a pathway to overcome some of these past challenges.
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Lymphatic filariasis, commonly known as elephantiasis, is a neglected tropical disease. Infection occurs when filarial parasites are transmitted to humans through mosquitoes. When a mosquito with infective stage larvae bites a person, the parasites are deposited on the person’s skin from where the
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y enter the body. The larvae then migrate to the lymphatic vessels where they develop into adult worms in the human lymphatic system.
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Human African trypanosomiasis (HAT), or sleeping sickness, is an endemic disease in 36 sub-Saharan African countries, typically occurring in underdeveloped areas, where
health systems face significant difficulties of diverse natures.
Website last accessed on 14.04.2023
Les trématodes d'origine alimentaire sont des zoonoses et leurs agents pathogènes ne peuvent être transmis à l'homme qu'après avoir accompli un cycle de vie complexe, dont certaines étapes se déroulent dans un hôte animal intermédiaire. Les premiers h
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ôtes intermédiaires de toutes les espèces de trématodes sont les escargots d'eau douce. Le deuxième hôte diffère selon l'espèce : dans le cas de la clonorchiase et de l'opisthorchiase, il s'agit de poissons d'eau douce, et dans le cas de la paragonimiase, de crustacés.
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Website last accessed ob 14.04.2023
Los trematodos transmitidos por los alimentos son zoonosis y sus patógenos sólo pueden transmitirse al ser humano tras completar un complejo ciclo vital, algunas de cuyas etapas tienen lugar en un hospedador animal intermediario. El primer hospedador interme
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diario de todas las especies de trematodos son los caracoles de agua dulce. El segundo hospedador difiere según la especie: en el caso de la clonorquiasis y la opistorquiasis son los peces de agua dulce, y en el de la paragonimiasis, los crustáceos.
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Website last accessed on 14.04.2023
Трематодозы пищевого происхождения являются зоонозами, и их возбудители могут передаваться человеку только после завершения сложного жизне
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нного цикла, некоторые стадии которого протекают в организме промежуточного животного хозяина. Первыми промежуточными хозяевами всех видов трематод являются пресноводные улитки. Второй хозяин бывает разным в зависимости от вида: в случае клонорхоза и описторхоза это пресноводные рыбы, а в случае парагонимоза — ракообразные.
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Website last accessed on 14.04.2023
One of the ongoing challenges with neglected tropical diseases (NTDs) is that the discovery of medicines to treat them has been very slow. Current global programmes for NTDs largely depend on donated medicines, primarily to treat the world’s poorest people
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most of whom live in remote rural or in deprived urban settings.
WHO recently spoke to Mr Robert J. Gyurik, who discovered albendazole in 1972. He took us through the journey that led him to develop the compound.
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