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Mpox Testing Strategy - November 2024

Africa Center for Disease Control and Prevention (2024) CC

Mpox is an emerging zoonotic disease caused by the mpox virus, a member of the Orthopoxvirus genus closely related to the variola virus that causes smallpox. Mpox was first discovered in 1958 when outbreaks of a pox-like disease occurred in monkeys kept for research. The first human case was recorde...d in 1970 in the Democratic Republic of the Congo (DRC) during a period of intensified effort to eliminate smallpox and since then the infection has been reported in a number of African countries. Mpox can spread in humans through close contact, usually skin-to-skin contact, including sexual contact, with an infected person or animal, as well as with materials contaminated with the virus such as clothing, beddings and towels, and respiratory droplets in prolonged face to face contact. People remain infectious from the onset of symptoms until all the lesions have scabbed and healed. The virus may spread from infected animals through handling infected meat or through bites or scratches. Diagnosis is confirmed by polymerase chain reaction (PCR) testing of material from a lesion for the virus’s DNA. Two separate clades of the mpox virus are currently circulating in Africa: Clade I, which includes subclades Ia and Ib, and Clade II, comprising subclades IIa and IIb. Clade Ia and Clade Ib have been associated with ongoing human-to-human transmission and are presently responsible for outbreaks in the Democratic Republic of the Congo (DRC), while Clade Ib is also contributing to outbreaks in Burundi and other countries. In 2022‒2023 mpox caused a global outbreak in over 110 countries, most of which had no previous history of the disease, primarily driven by human-to-human transmission of clade II through sexual contact. In just over a year, over 90,000 cases and 150 deaths were reported to the WHO. For the second time since 2022, mpox has been declared a global health emergency as the virus spreads rapidly across the African continent. On 13 Aug 2024, Africa CDC declared the ongoing mpox outbreak a Public Health Emergency of Continental Security (PHECS), marking the first such declaration by the agency since its inception in 2017.7 This declaration empowered the Africa CDC to lead and coordinate responses to the mpox outbreak across affected African countries. On August 14, 2024, the WHO declared the resurgence of mpox a Public Health Emergency of International Concern (PHEIC) emphasizing the need for coordinated international response. As of August 2024, Mpox has expanded beyond its traditional endemic regions, with new cases reported in countries including Sweden, Thailand, the Philippines, and Pakistan. Sweden has confirmed its first case of Clade 1 variant, which has been rapidly spreading in Africa, particularly in DRC. The emergence of this new variant raises concerns about its potential for higher lethality and transmission rates outside Africa. more

Cadre continental sur le renforcement des systèmes de surveillance de la mortalité en Afrique

Africa Center for Disease Control and Prevention (2023) CC

L'importance de systèmes de surveillance de la mortalité robustes ne peut être surestimée à une époque marquée par des défis sanitaires mondiaux croissants, où les menaces sanitaires pèsent lourd et la dynamique des populations continue d'évoluer. Des données précises et opportunes sur ...la mortalité sont essentielles pour identifier les tendances et détecter les menaces émergentes pour la santé, évaluer l'impact des interventions et orienter les décisions politiques fondées sur des données probantes. Ce cadre décrit une approche holistique pour renforcer les systèmes de surveillance de routine de la mortalité, en tenant compte des facteurs contextuels uniques et des défis auxquels sont confrontés les pays africains. Il souligne l'importance d'établir des mécanismes de collecte de données efficaces, d'améliorer la qualité et l'exhaustivité des données et de promouvoir le partage des données et la collaboration entre les parties prenantes. De plus, le cadre reconnaît le rôle central de la technologie dans l'intégration des données provenant de sources de données fragmentées sur la mortalité. Il met en évidence le potentiel des méthodes innovantes de capture de données, des analyses avancées et des systèmes de notification en temps réel pour améliorer la précision, l'efficacité et l'actualité des données sur la mortalité. Le cadre continental de surveillance de la mortalité s'aligne sur la mission et l'objectif stratégique d'Africa CDC en servant d'élément fondamental dans le renforcement des systèmes de santé publique, l'amélioration des capacités et des capacités de surveillance des maladies, l'élaboration de politiques et d'interventions fondées sur des données probantes et la promotion de la collaboration et de la coordination entre les pays africains pour relever les défis sanitaires et améliorer les résultats sanitaires sur le continent. La mise en œuvre réussie de ce cadre nécessite un engagement collectif et des efforts concertés de la part des gouvernements, des établissements de santé et de la communauté internationale. Nous espérons que ce document servira de catalyseur pour un changement transformateur, permettant aux pays de mettre en place des systèmes de surveillance de la mortalité résilients qui protègent la santé publique, sauvent des vies et contribuent à la prise de décision fondée sur des données probantes. more

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Status Report July - December 2014: Progress against the Polio Eradication and Endgame Strategic Plan 2013-2018

World Health Organization, Global Polio Eradication Initiative (2015) C1

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Доклад ВОЗ о глобальной табачной эпидемии, 2009 год- Создание среды, свободной от табачного дыма

World Health Organization (2010) C_WHO

Доклад ВОЗ о глобальной табачной эпидемии, 2009 год: Создание среды, свободной от табачного дыма, – второй из серии докладов ВОЗ, в которых определяется состояние таб... more

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The one health landscape in Sub-Saharan African countries

F. O. Fasina, Fasanmi O.G., Makonnen Y. J., et al. (2021) CC

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A position statement and practical guide to the use of particulate filtering facepiece respirators (N95, FFP2, or equivalent) for South African health workers exposed to respiratory pathogens includin

Dheda, K.; et al. (2022) CC

Afr J Thoracic Crit Care Med 2021;27(4):Published online 22 October 2021. https://doi.org/10.7196/AJTCCM.2021.v27i4.173

IOM Continental Strategy for Africa 2020–2024

International Organization for Migration IOM (2020) C1

Intra-African migration remains a dominant trend in contemporary African migration. The Strategy frames the Organization’s new orientation with <... at policy and strategic levels. It is consistent with the goals and objectives of the Global Compact for Safe, Orderly and Regular Migration (GCM) to which almost all African countries adhere, as well as the 2030 Agenda for sustainable development, the IOM strategic vision, and IOM Migration Governance Framework (MIGoF). more

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West Africa - Ebola Outbreak, Fact Sheet #39, Fiscal Year (FY) 2015 (as of July 14, 2015)

US Agency for International Development, Centers for Disease Control and Prevention (2015)

The Government of Liberia (GoL) reports three additional EVD cases linked to the Margibi County cluster, including one in Liberia’s Montserrado County; new confirmed case total reaches six Recently extended Operation Northern Push strengthens contact tracing and EVD prevention activities ... more

Tuberculosis Infection Control in the Era of Expanding HIV Care and Treatment: Addendum to WHO Guidelines for the Prevention of Tuberculosis in Health Care Facilities in Resource-limited Settings

Center for Disease Control and Prevention, World Health Organisation (2007)

The goal of this addendum is to help management and staff  minimize the risk of TB transmission at facilities in resource limited settings in which a.) HIV-infected persons receive diagnosis, care, treatment,  and/or support, and b.) there is a high prevalence of HIV infection, both known  and... more

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Diphtheria: NICD Recommendations for Diagnosis, Managementand Public Health Response

The National Institute For Communicable Diseases, South Africa (2018) C1

Liberia: National Policy and Strategic Plan on Health Promotion 2016-2021

Ministry of Health, Liberia; World Health Organization (WHO) (2016) C_WHO

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WHO Competency Framework for Health Workers’ Education and Training on Antimicrobial Resistance

World Health Organization WHO (2018) C_WHO

The framework is to be used as a reference guide, applied according to local priorities and needs, and targeted at academic institutions, educators, accreditation bodies, regulatory agencies and other users. The ultimate aim is to ensure that all health... more

Don’t pollute my future! The impact of the environment on children’s health

World Health Organization WHO (2017) C_WHO

In 2015, 5.9 million children under age five died (1). The major causes of child deaths globally are pneumonia, prematurity, intrapartum-related complications, neonatal sepsis, congenital anomalies, diarrhoea, injuries and malaria (2). Most of these diseases and conditions are at least partially cau... more

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Accountability for women’s and children’s health

Flavia Bustreo, Marie-Paule Kieny, Lale Say et al. World Health Organization WHO (2015) C_WHO

Progress Report

Policy on TB Control in Health Care Facilities, Congregate Settings and Households

World Health Organization WHO (2009)

This document is an evidence-based policy for the implementation of sound tuberculosis (TB) infection control by all stake- holders. It recommends a combination of measures aimed at reducing the risk of TB transmission within populations. The emphasis is on early and rapid diagnosis, and proper mana... more

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Partnering and public health practice

Stop TB Partnership; World Health Organization ; USAI (2013) C_WHO

Experience of national TB partnerships

Guidelines for the Prevention of Tuberculosis in Health Care Facilities in Resource-limited Settings

World Health Organization WHO (1999) C_WHO

These guidelines are designed for settings with limited resources to provide inexpensive and effective control strategies for prevention of TB transmission in health care workers (HCW).

Compendium of good practices in the health sector response to HIV in the WHO European Region

Dr. M. Dara; Z. T. Gavry; M. Mansfeld World Health Organization (Europe) (2018) C_WHO

Implementation manual to prevent and control the spread of carbapenem-resistant organisms at the national and health care facility level
recommended

World Health Organization WHO (2020) C_WHO

This manual presents a compelling case for action on carbapenem-resistant organisms (CROs) and describes the linkages between the prevention and control of CROs and the Global Action Plan on Antimicrobial Resistance (AMR). It describes how the eight recommendations contained within the ... Health Organization (WHO) guidelines for the prevention and control of carbapenem-resistant Enterobacteriaceae, Acinetobacter baumannii and Pseudomonas aeruginosa in health care facilities relate to general measures (that is, the core components of infection prevention and control [IPC] programmes) that need to be in place in all countries and health care facilities to prevent and control health care-associated infections (HAIs). The use of a stepwise approach is proposed to support implementation and improvement, based on the evidence and experience of what has worked in several health care settings worldwide. The focus is on adoptable and adaptable information. more

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WHO Sierra Leone 2016 - 2017: From Ebola to Health

World Health Organization (WHO) (2017) C_WHO

Implementation manual to prevent and control the spread of carbapenem-resistant organisms at the national and health care facility level recommended

Implementation manual to prevent and control the spread of carbapenem-resistant organisms at the national and health care facility level
recommended