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Chagas Disease For Health Care and Public Health Professionals

Centers for disease control and prevention CDC (2022) CC

Education and information about Chagas Disease, Triatomine bugs, Kissing Bugs, fact sheets, information for special groups, prevention and control, epidemiology, diagnosis and treatment for Health Professionals.

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Molecular and Clinical Aspects of Chronic Manifestations in Chagas Disease: A State-of-the-Art Review

Medina-Rincón, G.; Gallo-Bernal, S.; Jiménez, P.; et al. (2021) CC

Pathogens . 2021 Nov 16;10(11):1493.doi: 10.3390/pathogens10111493 .Chronic manifestations of Chagas disease present as disabling and life-threatening condi-tions affecting mainly the cardiovascular and gastrointestinal systems. Although meaningful research has outlined the different molecular mech... more

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Chagas disease: the scope and impact of the problem

Chagas Coalition (2022) CC

It is estimated that, in Latin America alone, between 6 and 8 million people are infected with the parasite, and 99% of these are not receiving treatment, either because they are unaware of their infection or because they do not know that treatment exists. The potential spread of the disease is also... more

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Chagas Disease

Cleveland Clinic (2021) C1

Chagas disease is a tropical parasitic infection transmitted by crawling, blood-sucking insects (kissing bugs). You may have flu-like symptoms or none at all. But the disease can lead to life-threatening complications. With prompt treatment, most people with Chagas disease, also known as American tr... more

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What is Chagas disease?

Medical News Today (2020) C1

Chagas disease, or American trypanosomiasis, is a condition that causes gradual organ damage. Without treatment, it can be fatal. This article explains where the T. cruzi parasite is most common and how it can spread. It also outlines the symptoms of Chagas disease and the treatment options avail... more

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Health beliefs and health seeking behavior towards lymphatic filariasis morbidity management and disability prevention services in Luangwa District, Zambia: Community and provider perspectives

Maritim, P., A. Silumbwe, J.M. Zulu, et al. (2021) C2

Lymphatic filariasis (LF) infection if untreated results in fluid accumulation in the limbs or breasts (lymphedema) or genitalia (hydrocele) that is painful and causes great discomfort. Morbidity management and disability prevention (MMDP) strategies such as surgery for hydrocele, treatment of acute... more

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Review Challenges in Chagas Disease Drug Development

Francisco, A.; Jayawardhana, S.; Olmo, F. et al. Molecules MDPI (2020) CC

The protozoan parasite Trypanosoma cruzi causes Chagas disease, an important public health problem throughout Latin America. Current therapeutic options are characterised by limited efficacy, long treatment regimens and frequent toxic side-effects. Advances in this area have been compromised by gaps... more

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Advances in preclinical approaches to Chagas disease drug discovery

Villalta, F.; Rachakonda, G. (2019) CC

Chagas disease affects 8-10 million people worldwide, mainly in Latin America. The current therapy for Chagas disease is limited to nifurtimox and benznidazole, which are effective in treating only the acute phase of the disease but with severe side effects. Therefore, there is an unmet need for new... more

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Chagas disease factsheet

Drugs for Neglected Diseases initiative DNDi - Latin America (2019) CC

Chagas is a parasitic disease that affects over 6 million people in the world. As the disease typically remains asymptomatic for years, new cases often go unnoticed and unreported, and most people with the disease are unaware of their condition. Less than 10% of people affected are diagnosed and... more

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Antimicrobial Resistance (AMR)

Deininger, K. The MEDBOX Team (2023) CC

Issue Brief 31: Antimicrobial resistance (AMR) can occur when viruses, bacteria, parasites and fungi change over time. There is no longer a response to medicines, and the infection treatment gets really difficult which increases the risk of a disesase spread, which can lead to severe health problems... more

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Schistosomiasis (Bilharzia): an acute and chronic neglected tropical disease

World Health Organization WHO (2022) C_WHO

Infographic Disease: Infection is widespread in poor communities, 221 million people affected worldwide... Affected Populations: Women, Children... Prevention and Control: WHO recommends praziquantel for treatment of all forms of schistosomiasis...

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Schistosomiasis Key Facts

World Health Organization WHO (2023) C_WHO

Schistosomiasis is an acute and chronic parasitic disease caused by blood flukes (trematode worms) of the genus Schistosoma. Estimates show that at least 251.4 million people required preventive treatment in 2021. Preventive treatment, which should be repeated over a number of years, will reduce and... more

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Reimagining the fight against Chagas disease

Novartis (2020) C1

Chagas disease affects approximately 6 million people, mainly in Latin America. Less than 1% of affected individuals receive proper antiparasitic treatment, and current drugs are inadequate to fight the entire spectrum of the disease. Against this background, Novartis is pursuing an end-to-end appro... more

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Supporting countries in their foodborne trematode infections control efforts

World Health Organization WHO (2023) C_WHO

WHO promotes the inclusion of foodborne trematodiases among the targets of preventive chemotherapy interventions. With the aim of providing access to quality medicines, WHO has negotiated with Novartis Pharma AG whereby Novartis donates triclabendazole for the treatment of fascioliasis and paragonim... more

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Clinical management of COVID-19: living guideline, 13 January 2023

World Health Organisation (WHO) (2023) C_WHO

As of 12 December 2022, over 645 million people worldwide have been diagnosed with COVID-19, with over 6.6 million deaths (4). The Omicron variant, which emerged in late November 2021, and its subvariants, are now the dominant circulating viruses, contributing to the ongoing surge in several countr... more

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Rabies Facts Dos and Don'ts

Department of Health and Environmental Control dhec (2022) CC

There is no cure for rabies, but it is 100 percent preventable through prompt, appropriate medical care. Every year hundreds of South Carolinians must undergo preventive treatment for rabies due to exposure to a rabid or suspected rabid animal. Although the cost varies, post-exposure treatment typic... more

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Rabies - Overview

National Health Service NHS (2023) CC

Rabies is a rare but serious infection that's usually caught from a bite or scratch of an infected animal. It's almost always fatal once symptoms appear, but vaccination and early treatment can prevent it.

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Rabies MSF medical guidlines

MSF medical guidelines (2018) CC

Rabies is a viral infection of wild and domestic mammals, transmitted to humans by the saliva of infected animals through bites, scratches or licks on broken skin or mucous membranes. In endemic areas (Africa and Asia), 99% of cases are due to dog bites and 40% of cases are children under 15 years... more

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The Mark of Neglect: Cutaneous Leishmaniasis

Drugs for Neglected Diseases initiative DNDi (2014) CC

Leishmaniasis is among the most neglected diseases. The most common form is cutaneous leishmaniasis that forms lesions on the skin. The only treatment available for cutaneous leishmaniasis is highly toxic. In some cases, patients have died because of the treatment, even though cutaneous leishmania... more

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CDC - Ascariasis

Centers for Disease Control and Prevention CDC (2023) C2

Website last accessed on 18.03.2023 Education and information about ascariasis, including fact sheets and information on prevention and control, epidemiology, diagnosis and treatment.