This chapter discusses the antibacterial treatment of leprosy infections. Antibiotic treatment is
a key component of leprosy treatment, as it is vital to prevent the progression of the infection.
Treatment with rifampin and other antibiotics is highly effective and cures 98% of patients with
the ...leprosy infection. Furthermore, the relapse rate is very low, at about 1% over 5–10 years.
There is little M. leprae drug resistance in leprosy and few reports of multi-drug resistance (1, 2, 3,
4, 5, 6, 7, 8). An antibiotic treatment may take months or years to produce clinical improvement,
especially in patients with an initial high bacterial index (BI).
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Mettre en œuvre la gestion des risques
associés aux soins en établissement de santé
Des concepts à la pratique
Arsenical monotherapies were previously very successful for treating human African trypanosomiasis (HAT).
Melarsoprol resistance emerged as early as the 1970s and was widespread by the late 1990s.
Melarsoprol resistance represents the only example of widespread drug resistance in HAT patients wher...e the genetic mechanism has been established.
The current goal of elimination of HAT as a public health problem by 2020 may be undermined by the emergence and spread of resistance to current or new drugs.
Insights into potential resistance mechanisms for current and new drugs will facilitate predictions of the likelihood of resistance and will also facilitate rational approaches to minimizing, monitoring, and tackling the future emergence of resistance.
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Ce guide a pour objectif de fournir des conseils pratiques à destination du personnel de santé entreprenant des activités de préparation et de réponse aux maladies infectieuses afin de maintenir l’accès à des Soins d’Avortement sans Risque (SAR) durant une épidémie de maladie infectieus...e. Il s’agit d’un guide pratique destiné à aider les acteurs du secteur de la santé à garantir le maintien des services de Soins d’Avortement sans Risque (SAR) pendant les épidémies et à veiller à ce que les considérations nécessaires en matière de Soins d’Avortement sans Risque soient intégrées à la riposte à l’épidémie; il ne s’agit pas d’un guide clinique. Ce document se concentre sur les situations de crise humanitaire et les contextes fragiles, toutefois les recommandations peuvent s’appliquer aux épidémies de maladies infectieuses auprès des populations à faibles ressources. Ce guide est prévu en complément du document: Santé et droits en matière de sexualité et de procréation durant les épidémies de maladies infectieuses: orientations de mise en oeuvre pour les situations de crise humanitaire et les contextes fragiles.
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BMJ Open 2021;11:e042279. doi:10.1136/bmjopen-2020-042279. Neglected tropical diseases tend to cluster in the same poor populations, and to make progress with their control, they will have to be dealt with in an integrated manner. Peptide microarrays may be a solution to tese problems, where diagnos...is for co-infection can be detected simultaneously using the one tool.
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CEPI is seeking to raise $3.5 billion to implement CEPI’s next 5-year plan. To mitigate the immediate threat of COVID-19 variants, it is activating key elements of this plan now—and seeking to mobilise a portion of this $3.5 billion in 2021. We have already launched R&D programmes to initiate de...velopment of next-generation vaccines against COVID-19 variants and we are planning studies to answer critical scientific questions related to the durability of immunity, effectiveness of mixed-vaccine regimens, and vaccine effectiveness in vulnerable populations such as pregnant women. We are also bringing forward our plans to develop vaccines that could protect against multiple COVID-19 variants and other coronavirus specie
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The definition of Official Development Assistance (ODA) has for 40 years been the global standard for measuring donor efforts in supporting development co-operation objectives. It has provided the yardstick for documenting the volume and the terms of the concessional resources provided, assessing do...nor performance against their aid pledges and enabling partner countries, civil society and others to hold donors to account. Yet for all its value, the ODA definition has always reflected a compromise between political expediency and statistical reality. It is based on interpretation and consensus and therefore allows for flexibility. It has evolved over the decades, while preserving the original concepts of a definition based on principal developmental motivation, official character and a degree of concessionality. While agreement on the ODA concept was a major achievement, discussion of the appropriateness of this measure has never ended. The paper documents the evolution of the ODA concept and proposes a possible new approach to measuring aid effort.
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To provide information on trends on official development assistance (ODA) disbursement patterns for
reproductive health activities in 18 conflict-affected countries
This threat assessment addresses the implications of the ongoing Marburg virus disease (MVD) outbreak in
Rwanda for the European Union/European Economic Area (EU/EEA). MVD is a severe disease in humans and,
although uncommon, it has the potential to cause epidemics with significant case fatality. ...All recorded MVD
outbreaks to date have originated in Africa. MVD is not an airborne disease and is considered not to be
contagious before symptoms appear. Direct contact with the blood and other body fluids of infected people
and animals or indirect contact with contaminated surfaces and materials like clothing, bedding and medical
equipment is required for transmission. The risk of infection is minimised when proper infection prevention and
control precautions are strictly followed. There is no approved treatment or vaccine for MVD; however, several
pharmaceuticals and candidate MVD vaccines are under investigation.
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This brief highlights the urgency of addressing gender inequalities across the Rio Conventions, provides examples of where progress has been made, and identifies clear entry points for addressing gender equality considerations across the Conventions. It makes recommendations for actions to accelerat...e the synergistic implementation of the gender provisions and action plans of the Conventions.
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The 2018 Humanitarian Response Plan (HRP) aimed to assist 10.5 million people with direct assistance and 11.2 million people with improved access to basic services. In an effort to meet humanitarian needs, humanitarian partners provided various types of humanitarian life-saving and life-sustaining... assistance and services to a monthly average of 5.5 million people during 2018. Of the 5.5 million people reached on average on a monthly basis, 2.1 million were people living in areas of high severity of need, as measured through the inter-sector severity scale.
In 2018, these efforts were funded by international support to Syria with $2.19 billion raised (65 per cent of HRP requirements) by the end of the year – more than any previous year. Thanks to this generous support, humanitarian organisations in Syria continued to deliver a massive humanitarian response to people in need with multiple humanitarian crises unfolding across the country.
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A elaboração das Diretrizes para Diagnóstico e Tratamento da COVID-19 é uma resposta rápida ao enfrentamento da COVID-19, diante da declaração de pandemia pela Organização Mundial de Saúde (OMS) e das iniciativas do Ministério da Saúde para enfrentamento dessa nova situação no Brasil. ...
A intensa produção de evidência sobre o assunto nos últimos meses faz destas Diretrizes um documento dinâmico que terá versões provisórias e atualizações periódicas, acompanhando a produção de novas evidências para assim estabelecer recomendações.
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A elaboração das Diretrizes para Diagnóstico e Tratamento da COVID-19 é uma resposta rápida ao enfrentamento da COVID-19, diante da declaração de pandemia pela Organização Mundial de Saúde (OMS) e das iniciativas do Ministério da Saúde para enfrentamento dessa nova situação no Brasil. ...
A intensa produção de evidência sobre o assunto nos últimos meses faz destas Diretrizes um documento dinâmico que terá versões provisórias e atualizações periódicas, acompanhando a produção de novas evidências para assim estabelecer recomendações.
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The Advancing Climate-Resilient Education Technical Guidance builds on the USAID 2022–2030 Climate Strategy and the 2018 USAID Education Policy to support USAID Missions and partners who seek to integrate climate action and awareness into educatio...n programs and are committed to achieving climate-resilient education systems and fostering climate-resilient learners. It outlines how to identify opportunities for climate action that respond to known climate hazards through mitigative, adaptive, and transformative actions.
The guidance is designed for use at the activity design and monitoring and evaluation stages of the USAID Program Cycle. It does not prescribe new processes, but rather serves to aid Missions and partners in integrating climate considerations into existing processes
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Malawi is a small and beautiful country in south-central Africa. It is divided into three administrative regions: south, central and north. The regions are further subdivided into 28 districts. The Southern Region is the most densely populated, while the Northern Region is the least populated.
Pour le personnel de santé et les travailleurs de la nutrition dans les situations d’urgence
Le règlement du Parlement européen et du Conseil européen n°604-2013 du 26 juin 2013, dit « Règlement Dublin III », est un texte normatif de l'Union européenne, de 49 articles, consacré au règlement juridiqü du droit d'asile en vertu de la Convention de Genève (art. 51) dans l'Union euro...péenne pour des étrangers qui formulent une demande d'asile dans un pays et sont interpellés dans un autre pays de l'Union européenne.
Pour versions en autres langüs allez voir sur http://eur-lex.europa.eu/legal-content/FR/TXT/?qid=1445168658921&uri=CELEX:32013R0604
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