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Mpox Testing Strategy - November 2024

Africa Center for Disease Control and Prevention (2024) CC

Mpox is an emerging zoonotic disease caused by the mpox virus, a member of the Orthopoxvirus genus closely related to the variola virus that causes smallpox. Mpox was first discovered in 1958 when outbreaks of a pox-like disease occurred in monkeys kept for research. The first human case was recorde...d in 1970 in the Democratic Republic of the Congo (DRC) during a period of intensified effort to eliminate smallpox and since then the infection has been reported in a number of African countries. Mpox can spread in humans through close contact, usually skin-to-skin contact, including sexual contact, with an infected person or animal, as well as with materials contaminated with the virus such as clothing, beddings and towels, and respiratory droplets in prolonged face to face contact. People remain infectious from the onset of symptoms until all the lesions have scabbed and healed. The virus may spread from infected animals through handling infected meat or through bites or scratches. Diagnosis is confirmed by polymerase chain reaction (PCR) testing of material from a lesion for the virus’s DNA. Two separate clades of the mpox virus are currently circulating in Africa: Clade I, which includes subclades Ia and Ib, and Clade II, comprising subclades IIa and IIb. Clade Ia and Clade Ib have been associated with ongoing human-to-human transmission and are presently responsible for outbreaks in the Democratic Republic of the Congo (DRC), while Clade Ib is also contributing to outbreaks in Burundi and other countries. In 2022‒2023 mpox caused a global outbreak in over 110 countries, most of which had no previous history of the disease, primarily driven by human-to-human transmission of clade II through sexual contact. In just over a year, over 90,000 cases and 150 deaths were reported to the WHO. For the second time since 2022, mpox has been declared a global health emergency as the virus spreads rapidly across the African continent. On 13 Aug 2024, Africa CDC declared the ongoing mpox outbreak a Public Health Emergency of Continental Security (PHECS), marking the first such declaration by the agency since its inception in 2017.7 This declaration empowered the Africa CDC to lead and coordinate responses to the mpox outbreak across affected African countries. On August 14, 2024, the WHO declared the resurgence of mpox a Public Health Emergency of International Concern (PHEIC) emphasizing the need for coordinated international response. As of August 2024, Mpox has expanded beyond its traditional endemic regions, with new cases reported in countries including Sweden, Thailand, the Philippines, and Pakistan. Sweden has confirmed its first case of Clade 1 variant, which has been rapidly spreading in Africa, particularly in DRC. The emergence of this new variant raises concerns about its potential for higher lethality and transmission rates outside Africa. more

Antimicrobial Resistance Surveillance Guidance for the African Region

Africa Center for Disease Control and Prevention (2024) CC

Antimicrobials are medicines, including antibiotics, antivirals, antifungals, and antiparasitics, that are used to prevent and treat infections in humans, animals, and plants. Antimicrobial Resistance (AMR) arises when bacteria, viruses, fungi, and parasites no longer respond to these medicines, ren... more

Targeted and selective strategies in measles and rubella vaccination campaigns: Interim guidance

World Health Organization WHO (2025) C_WHO

The World Health Organization provides regional and national strategies and operational plans that aim to support countries in work to achieve measles control and elimination. These are guided by high level frameworks including the Immunization Agenda 2030 and the Measles and Rubella Strategic Frame... more

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Making every school in the Region of the Americas a health-promoting school: Implementation guide for educational institutions

Pan American Health Organization PAHO (2024) CC

Every day, schools engage in numerous activities that help promote the health and well-being of students, families, and communities. There is clear evidence of the benefits of the health-promoting schools (HPS) approach, not only for improving overall health outcomes (physical, mental, and social) i... more

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Diretrizes de Estimulação Precoce Crianças de zero a 3 anos com Atraso no Desenvolvimento Neuropsicomotor Decorrente de Microcefalia

Ministério da Saúde do Brasil, Secretaria Atenção à Saúde (2016) C1

Versão preliminar

Malawi National Occupational Safety and Health Programme 2016-2016

International Labor Organization (ILO); European Union; Malawi Government (2010) C1

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GLI Guide to TB Specimen Referral Systems and Integrated Networks

Global Laboratory Initiative (GLI), Stop TB Partnership (2018) C1

This guide includes information relevant for tuberculosis (TB) program and laboratory managers, as well as Ministry of Health officials across disease programs interested in establishing integrated solutions for specimen referral. Though TB-focused in name, it offers integration-oriented assessment,... more

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Roadmap towards ending TB in children and adolescents
recommended

World Health Organization WHO (2018) C_WHO

2nd edition. The 2018 Roadmap incorporates an additional critical population: adolescents. Despite making up 1 in 6 of the world’s people, adolescents have been largely overlooked as global momentum to address TB has grown. Spanning the ages of 10–19 years, adolescents are both at risk of TB and... more

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Rwanda: Ebola Preparedness Emergency Plan of Action (EPoA) Final Report - DREF Operation n° MDRRW017

International Federation of Red Cross And Red Crescent Societies (2019) C1

Eleven (11) districts in Rwanda were initially were considered most at risk of the outbreak, namely: • Rusizi, Nyamasheke, Karongi, Rutsiro, Rubavu (bordering DRC) • Musanze, Burera, Gicumbi and Nyagatare (bordering Uganda) • Kigali city (comprised of 3 localities) due to the presence of Ki... more

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A Review of Community Health Worker (CHW) knowledge, attitudes and practices relating to the sexual health of MSM, including existing training materials and manuals in Europe & neighbouring countries

C. Folch; P. Fernández-Dávila; J. Palacio-Vieira; et al. European Commission; Centre d'Estudis Epidemiològics sobre les Infeccions de Transmissió Sexual i Sida de Catalunya (CEEISCAT); European AIDS Treatment Group (2020) C2

Accessed: 07.03.2020 A Review of Community Health Worker (CHW) knowledge, attitudes and practices relating to the sexual health of MSM, including existing training materials and manuals in Europe and neighbouring countries (D5.1) Contract 2015 71 01 A behavioural survey for HIV/AIDS and assoc... more

Critical preparedness, readiness and response actions for COVID-19
recommended

World Health Organization WHO (2021) C_WHO

27 May 2021 All countries should increase their level of preparedness, alert and response to identify, manage and care for new cases of COVID-19. Countries should prepare to respond to different public health scenarios, recognizing that there is no one-size-fits-all approach to managing cases and o... more

Responding to COVID-19: Guidance for humanitarian agencies

ALNAP; CERAH; LSHTM (2020) C2

How should humanitarian organisations prepare and respond to COVID-19 in humanitarian settings in low- and middle-income countries? This Rapid Learning Review outlines 14 actions, insights and ideas for humanitarian actors to consider in their COVID-19 responses. It summarises and synthesises the... more

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Interim Guidance on Public Health and Social Measures for COVID-19 Preparedness and Response Operations in Low Capacity and Humanitarian Settings

Inter-Agency Standing Committee IASC (2020) C1

This Interim Guidance outlines how key public health and social measures needed to reduce the risk of COVID-19 spread and the impact of the disease can be adapted for use in low capacity and humanitarian settings. The recommendations outlined here need to be adjusted to the scale of transmission, co... more

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Advice to Parents. Supporting your children through the COVID-19 lockdown

Ministry of Health, South Africa (2020) CC

The Department of Basic Education recognises the need to help parents and guardians get through this lockdown period as effectively as possible. This simple set of guidelines is designed to provide advice and strategies to help parents support their children at this time

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Regional Refugee and Resilience Plan (3RP) in Response to the Syria Crisis: Regional Strategic Overview 2020/2021

UN Development Programme UNDP; UN High Commissioner for Refugees UNHCR (2020) C1

CARE Rapid Gender Analysis of COVID-19 in Myanmar

CARE (2020) CC

7 June 2020 Version 1 Women in Myanmar have traditionally been underrepresented in public decision-making processes, a trend which is continuing in structures established to respond to COVID-19. This means that even as women are disproportionately affected by the crisis, they have less say in how t... more

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Carta Encíclilca laudato si'del Santo Padre Francisco sobre el Cuidado de la casa común

Holy Father Francis Vatican Press (2015) C2

Carta del santo padre

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COVID References top 10 Daily Science. Vol.1 (30 December 2019 – 15 October 2020)

Hoffmann, C.; B.S. Kamps (2020) CC

There is no secret to our procedure: the daily scanning of the literature helps us to stay afloat in the never-ending waves of new publications about SARS-CoV-2 and COVID-19. Many papers discussed in the Top 10 will eventually make it into subsequent editions of COVID Reference.

Laudato si' (24 de mayo de 2015) | Francisco

Pope Franciscus Librera Vaticano (2015) CC

Carta Encíclica Laudato Si' de Santo Padre Francisco sobre el cuidado de la case común

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Health at a Glance: Latin America and the Caribbean 2020

OECD; The World Bank (2020) C1

Thefirst report on Latin America and the Carribean presents key indicators on health and health systems in 33 Latin America and the Caribbean countries. . Analysis is based on the latest comparable data across almost 100 indicators including equity, health status, determinants of health, health car... more

Roadmap towards ending TB in children and adolescents recommended

Critical preparedness, readiness and response actions for COVID-19 recommended

Roadmap towards ending TB in children and adolescents
recommended

Critical preparedness, readiness and response actions for COVID-19
recommended