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Direct acting antivirals (DAAs) have revolutionized treatment for hepatitis C. Combi- nations of DAAs can cure infection with HCV in 12 weeks, are highly effective and have limited side-effects. Affordability of DAAs has improved significantly, but access remains lim- i ... more
Manual for Early Implementation
Systematic screening for active tuberculosis: an operational guide.
Training for staff working at DR-TB management centres. Training modules

Prevalence of drug-resistant tuberculosis in Nigeria: A systematic review and metaanalysis

C. C. Onyedum, I. Alobu, K. N. Ukwaja PLOS One; O. Neyrolles (Institut de Pharmacologie et de Biologoie Structurale) (2017) CC
PLoS ONE 12(7): e0180996. https://doi.org/10.1371/journal.pone.0180996
Moving avidence into action This document is part of a series of briefs for health program managers interested in implementing evidence-based programs. With a special emphasis on underutilized interventions, they present evidence on programs that work and provide guidance and resources for replicat ... more
Policy and Manual
The 23rd meeting of the WHO Expert Committee on Selection and Use of Essential Medicines was coordinated from Geneva, Switzerland, and held virtually from 21 June to 2 July 2021. The Committee considered 88 applications proposing additions, changes and deletions of medicines, medicine classes and fo ... more

Double trouble: tuberculosis and substance abuse in Nagaland, India

R. Shenoy, M. Das, H. Mansoor, et al. International Union Against Tuberculosis and Lung Disease (2015)
Public Health Action vol 5 no 3 published 21 september 2015
Year one report
Copenhagen, Denmark, 24–25 August 2017

Review of the national tuberculosis programme in Belarus

P. de Colombani World Health Organization Europe (2016) C_WHO
8–18 December 2015
4–15 February 2013
2006-2008 programme report
This concept note describes the methods used to assess the prevalence of any HIVDR and HIVDR by PMTCT exposure among children less than 18 months of age using remnant dried blood spot specimens from early infant diagnosis over a 12-month period
DHS Working Papers No. 85
As part of the Mental Health Gap Action Programme, WHO has developed training manuals (Training of trainers and supervisors training manual and Training of health-care providers training manual) to support implementation of the mhGAP Intervention Guide for mental, neurological and substance use (MNS ... more
Exposure draft for comment October 2013
Version: 24 April 2018
The consolidated guidelines are expected to provide the basis and rationale for the development of national guidelines for LTBI management, adapted to the national and local epidemiology of TB, the availability of resources, the health infrastructure and other national and local determinants. The gu ... more
The 2010-2011 National Annual Report on HIV program presents the progress in implementing the strategies and activities articulated in the National Strategic Plan on HIV and AIDS 2009-2012 commonly referred to as the HIV NSP. The report presents consolidated information regarding the outputs in the ... more
The WHO South-East Asia (‎SEA)‎ Region bears a high burden of tuberculosis (‎TB)‎ and MDR-TB. In 2015, the Region accounted for nearly 200 000 or 35% of the global estimated new RR/MDR-TB cases eligible for treatment. Extensively drug-resistant TB (‎XDRTB)‎ has also been reported from s ... more
The ICF Practical Manual provides information on how to use ICF. Anyone interested in learning more about use of the International Classification of Functioning, Disability and Health (ICF, WHO 2001) may benefit from reading this Practical Manual. The ICF is presently used in many different contexts ... more
The evidence base for differentiated care for stable patients has grown in recent years. There has been less attention, however, to developing differentiated models of care for patients with advanced or unstable HIV disease. Current clinical guidelines and policies regarding optimal packages of care ... more
This document is meant to respond to the questions:
■ What health interventions should the adolescent receive and when should s/he receive it?
■ What health behaviours should the adolescent practise (or not practise)?
Myanmar is one of the world’s 22 high tuberculosis (TB) burden countries, and supporting TB control in Myanmar is a global priority. This report reflects the findings, discussions, conclusions and recommendations of the fourth international review mission of the Myanmar National TB Programme (NTP) ... more
Maternal and child malnutrition is a significant public health problem in South Sudan. Among children aged 6-59 months, 31% are stunted, 28% are underweight, and nearly 23% are acutely malnourished of which 13% are estimated to suffer from moderate acute malnutrition and 10% from severe acute malnut ... more
The review’s objectives are to review progress in TB control with emphasis on DOTS strategy implementation, summarize the experience, lessons learnt and methods of work and to make recommendations for international donors, technical agencies and the Ministry of Health.
The purpose of this manual is to provide guidance in the design, implementation and evaluation of a course that aims to build and strengthen the capacity of health personnel to manage eye patients at primary-level health facilities in the African Region. The course falls within the remit of continuo ... more

Field Guide for the Management of Drug-Resistant Tuberculosis

A. Piubello The International Union Against Tuberculosis and Lung Disease (2018)
A practical tool to help health workers in the clinical and operational management of multidrug-resistant tuberculosis with special focus on the introduction, implementation and management of the nine-month treatment regimen.
JIMSA Jan.-March 2015 Vol. 28 no.1 p.47-50e
Guidelines on obstructive sleep apnea in India.
The update of the ESTC was conducted as a joint endeavour with ERS, consulting experts from international societies and organisations, national TB programmes, civil society and affected communities. The second edition of the ESTC includes 21 standards in the areas of diagnosis, treatment, HIV and co ... more
Policy and systems. Global Mental Health(2017),4, e7, page 1 of 6. doi:10.1017/gmh.2017.3
Overview Learning objectives • Promote respect and dignity for children and adolescents with mental and behavioural disorders. • Know common presentations of children and adolescents with mental and behavioural disorders. • Know assessment principles of child and adolescents with mental ... more
Received Date: Jun 15, 2017; Accepted Date: Jun 28, 2017; Published Date: Jun 30, 2017 Citation: Etindele Sosso FA, Nakamura O, Nakamura M (2017) Epidemiology of Alzheimer’s Disease: Comparison between Africa and South America. J Neurol Neurosci Vol.8 No.4:204. DOI: 10.21767/2171-6625.1000204 ... more

Diagnosis of dementia

World Health Organization (2012) C_WHO
Q6: Can dementia be diagnosed at first or second level care by non-specialist health care providers? What should be the assessment process for the diagnosis of dementia?
6th edition
Meeting Report 27–30 June 2017 Manila, Philippines

Clinical manifestations of HIV infection

M. Giles; C. Workman; C. Rodgers ashm hiv management in Austalasia (2019) C2
Assecced: 03.09.2019

Диагностика и лечение туберкулеза с множественной лекарственной устойчивостью возбудителя

Васильева Ирина Анатольевна, Самойлова Анастасия Геннадьевна, Эргешов Атаджан Эргешович et al. федеральное государственное бюджетное учреждение центральный научно-исследовательский институт туберкулеза российской академии медицинских наук, Американский международный союз здравоохранения (2012) C2
Cовершенствование теоретических знаний и практических навыков по вопросам диагностики и лечения туберкулеза с множественной лекарственной устойчивостью (МЛУ) ми ... more

HIV Programme Review in Belarus

D. Raben; J. Klinte; A. Sönnerborg; E. Subata, World Health Organization (Europe); Centre for Health & Infectious Disease Research (2015) C_WHO
Evaluation report November 2014

Population size estimate of people who inject drugs (PWID) in the Republic of Kazakhstan

Ganina L.Yu; Yelizaryeva A. V.; Saparbekov M. K.; et al. Ministry of Health and Social Development of the Republic of Kazakhstan Republican Center for AIDS Prevention and Control (2016) C2
Report Almaty, 2016 Authors: Ganina L.Yu., head of epidemiology department, Republican AIDS Center (RAC), Yelizaryeva A. V., epidemiologist, RAC, Kaspirova А. А., head of epidemiology department, Aktobe Oblast AIDS center, IvakinV.Yu., deputy regional director for strategic information, ICA ... more
A Cost-Efficiency Analysis for the Kyrgyz Republi

Modelling an Optimised Investment Approach for Tajikistan

The Republic of Tajikistan; UNDP (2014) C2
Getting to Zero Sustainable Financing of National HIV Responses

Paediatric - HIV Care and Treatment

USAID; Pata; South to South Zoe life; et al. (2019) C2
Accessed: 08.10.2019
PLOS ONE | https://doi.org/10.1371/journal.pone.0210937 February 5, 2019
In many low- and middle-income countries, there is a wide gap between evidencebased recommendations and current practice. Treatment of major CVD risk factors remains suboptimal, and only a minority of patients who are treated reach their target levels for blood pressure, blood sugar and blood choles ... more
Journal of Infection and Public Health 12 (2019) 213–223
Recommendations for a public health approach HIV/AIDS Programme

Special edition: HIV in MSM

I. Steffens; K. Hagmaier; K. Wilson; et al. Eurosurveillance (Europe’s journal on infectious disease epidemiology, prevention and control); European Centre for Disease Prevention and Control (2015) C2
Eurosurveillance Impact Factor 5.7 June 2015 www.eurosurveillance.org Featuring a series of articles on HIV and STI epidemiology, prevention and control among MSM in Europe
Consolidated Guidelines Geneva, 2016 The End TB Strategy
The aim of the operational framework is to ensure 1) accurate collection, handling, shipment and storage of specimens collected in countries implementing HIV drug resistance surveillance; and 2) the availability of quality-assured HIV genotyping laboratory services producing comparable and reliable ... more
WHO recommends that pre-exposure prophylaxis (PrEP) be offered as an additional prevention choice for HIV-negative individuals at substantial risk of HIV infection as part of combination prevention approaches. HIV drug resistance has been rarely reported among PrEP users who tested HIV positive i ... more
Technical Brief July 2017
The following protocol has been designed to investigate the First Few X cases (FFX) and their close contacts. It is envisioned that the FFX 2019-nCoV investigation will be conducted across several countries or sites with geographical and demographical diversity. Using a standardized protocol such a ... more
This is a case-ascertained prospective investigation of all identified health care contacts working in a health care facility in which a laboratory confirmed 2019-nCoV infected patient (see 2.2 Study population) receives care. Note that this study can be done in health care facilities at all 3 level ... more
2011-2015
These guidelines form part of efforts to institutionalise the prevention and containment of antimicrobial resistance (AMR) in health care facilities in South Africa, as outlined in the Antimicrobial Resistance Strategic Framework and Implementation Plan. The focus of these guidelines is on two inte ... more
An essential participant in antimicrobial stewardship who has been unrecognized and underutilized is the“staff nurse.”Although the role of staff nurses has not formally been recognized in guidelines for implementing and operating antimicrobial stewardship programs (ASPs) or defined in the medica ... more

COVID -19 Outbreak Guidelines for Setting up Isolation Facility/Ward

Ministry of Health & Family Welfare Government of India; Na􏰀tional Centre for Disease Control Ministry of Health & Family Welfare Government of India; Na􏰀tional Centre for Disease Control (2020) C2
Accessed: 16.04.2020
The following protocol has been designed to investigate the extent of infection, as determined by seropositivity in the general population, in any country in which COVID-19 virus infection has been reported. Each country may need to tailor some aspects of this protocol to align with public health, l ... more
The role of environmental contamination in transmission of COVID-19 virus is currently not clear. This protocol has been designed to determine (viable) virus presence and persistence on fomites in various locations where a patient infected with COVID-19 is currently receiving care or being isolated, ... more
Based on Human Rights Watch (HRW)'s reporting on the human rights dimensions of the COVID-19 pandemic (see Related Summary, and the video, below), this document presents 40 questions to provoke thinking about a rights-respecting response to the crisis. The questions address the needs - including aro ... more
This brief provides key considerations for engaging communities on COVID-19 and tips for how to engage where there are movement restrictions and physical distancing measures in place, particularly in low-resource settings.
This document aims to provide global guidance on poliomyelitis (polio) surveillance in the context of the COVID-19 pandemic. It comes as a technical complement to Polio eradication programme continuity, Immunization in the context of COVID-19 pandemic frequently asked questions, and is aligned with ... more
Updated July 3, 2020
Integrated Management of Acute Malnutrition National Guidelines
This document aims to provide guidance to healthcare facilities and healthcare providers in the European Union/European Economic Area (EU/EEA) and the United Kingdom (UK) on preparedness and infection prevention and control (IPC) measures for the management of possible and confirmed cases of COVID-1 ... more
The Zambia Population Based HIV impact assessment of 2016, reported the prevalence of viral hepatitis in Zambia as ranging between 5.6% among adults aged 15 to 59% in the general population, and 7.1% among HIV infected individuals. It is estimated that the majority of persons with chronic hepatitis ... more
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV‑2) causing coronavirus disease 2019 (COVID-19) has reached pandemic levels; Patients with cardiovascular (CV) risk factors and established cardiovascular disease (CVD) represent a vulnerable population when suffering from COVID-19; Patien ... more
Increasing the Odds: A Series to Understanding Gambling Disorders. Vol.7 All editions of Increasing the Odd sare available as a free download at https://www.icrg.org/resources/monographs
Meeting Report 27-29 October 2020 The overall goal of the meeting was to discuss recent changes in treatment regimens and diagnostics for drug-resistant TB and to determine how these impact on the definition of XDR-TB, with a view to revising this definition. The pre-existing definition of XDR-TB w ... more
In resource restriced countries
The WHO operational handbook on tuberculosis: tuberculosis preventive treatment is the companion, implementation guide to the 2020 WHO guidelines on TB preventive treatment.[1] Just as these guidelines are the first to be released under the rubric of the WHO consolidated TB guidelines, this handbook ... more
Many critical questions remain about the effectiveness of COVID-19 vaccines in real-world settings. These questions can only be answered in post-introduction vaccine effectiveness studies.This guidance document outlines an approach to leverage existing surveillance systems for Severe Acute Respirato ... more
he WHO South-East Region in 2019 accounted for nearly a million missing TB patients from the estimated incidence. Active case-finding (ACF) or systematic screening for tuberculosis is an important tool to reach out to missing TB patients. When appropriately implemented, the activity is cost effectiv ... more