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Estimating the population at risk with soil transmitted helminthiasis and annual drug requirements for preventive chemotherapy in Ogun State, Nigeria

Mogaji H.O., Johnson O.O. , Adigun A.B. et al Nature (2022) C2

Soil transmitted helminth (STH) infections are among the most common human infections worldwide with over 1 billion people affected. Many estimates of STH infection are often based on school-aged children (SAC). This study produced predictive risk-m...aps of STH on a more finite scale, estimated the number of people infected, and the amount of drug required for preventive chemotherapy (PC) in Ogun state, Nigeria. Georeferenced STH infection data obtained from a cross-sectional survey at 33 locations between July 2016 and November 2018, together with remotely-sensed environmental and socio-economic data were analyzed using Bayesian geostatistical modelling. Stepwise variable selection procedure was employed to select a parsimonious set of predictors to predict risk and spatial distribution of STH infections. The number of persons (pre-school ages children, SAC and adults) infected with STH were estimated, with the amount of tablets needed for preventive chemotherapy. An overall prevalence of 17.2% (95% CI 14.9, 19.5) was recorded for any STH infection. Ascaris lumbricoides infections was the most predominant, with an overall prevalence of 13.6% (95% CI 11.5, 15.7), while Hookworm and Trichuris trichiura had overall prevalence of 4.6% (95% CI 3.3, 5.9) and 1.7% (95% CI 0.9, 2.4), respectively. The model-based prevalence predictions ranged from 5.0 to 23.8% for Ascaris lumbricoides, from 2.0 to 14.5% for hookworms, and from 0.1 to 5.7% for Trichuris trichiura across the implementation units. The predictive maps revealed a spatial pattern of high risk in the central, western and on the border of Republic of Benin. The model identified soil pH, soil moisture and elevation as the main predictors of infection for A. lumbricoides, Hookworms and T. trichiura respectively. About 50% (10/20) of the implementation units require biannual rounds of mass drug administration. Approximately, a total of 1.1 million persons were infected and require 7.8 million doses. However, a sub-total of 375,374 SAC were estimated to be infected, requiring 2.7 million doses. Our predictive risk maps and estimated PC needs provide useful information for the elimination of STH, either for resource acquisition or identifying priority areas for delivery of interventions in Ogun State, Nigeria. more

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SARS-CoV-2 Seroprevalence in a Rural and Urban Household Cohort during First and Second Waves of Infections, South Africa, July 2020–March 2021

Kleynhans, J.; et al. (2021) C_CDC

EID Journal , Volume 27, no.12 , Dec. 2021. Early Release Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections may be underestimated because of limited access to testing. We measured SARS-CoV-2 seroprevalence in South Africa every 2 months during July 2020–March 2021 in randoml... more

Burden of fungal asthma in Africa: A systematic review and meta-analysis

Kwizera, R.; Musaazi, J.; Meya, D.B.; et al. PLOS ONE, which is part of the Public Library of Science (PLOS) (2019) CC2

Asthma is one of the neglected diseases in Africa with a high prevalence. Allergic fungal diseases have been reported to complicate asthma progression and treatment outcomes. However, data about fungal asthma ... its associated complications are limited in Africa. We aimed to estimate the burden of fungal asthma among adults and children in Africa using a systematic review. more

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Rwanda: National Policy for Orphans and Other Vulnerable Children

Ministry of Local Government, Information and Social Affairs (Rwanda) (2003) C2

The following document outlines the principles, objectives and strategies of a national policy for the protection of orphans and other vulnerable children... in Rwanda. The propositions constitute a first step towards a comprehensive framework, which will assist the Government and its partners to plan, implement and monitor projects and programmes in favour of orphans and other vulnerable children. more

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“We Have to Be Worried”. The Impact of Lead Contamination on Children’s Rights in Kabwe, Zambia

Human Rights Watch (2019) C1

Children in Kabwe are especially at risk because they are more likely to ingest lead dust when playing in the soil, their brains and bodies are still developing, ... they absorb four to five times as much lead as adults. The consequences for children who are exposed to high levels of lead and are not treated include reading and learning barriers or disabilities; behavioral problems; impaired growth; anemia; brain, liver, kidney, nerve, and stomach damage; coma and convulsions; and death. After prolonged exposure, the effects are irreversible. Lead also increases the risk of miscarriage and can be transmitted through both the placenta and breastmilk. more

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Tanzania Malaria Indicator Survey (TMIS) Key Indicators 2017

Ministry of Health, Community Development, Gender, Elderly and Children; Ministry of Health; National Bureau of Statistics (NBS); Office of Chief Government Statistician (OCGS) (2018) C1

The primary objectives of the 2017 TMIS are to measure the level of ownership and use of mosquito nets; assess coverage of intermittent preventive treatment for pregnant women; identify treatment practices, including the use of specific... more

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Ukraine received more than 700K doses of tetanus-diphtheria vaccine from UNICEF

UN Childrern's Fund Reliefweb OCHA Services (2021) C_UNICEF

To survive and thrive from early childhood through to adolescence and beyond, children need to be healthy. This enables them to access education so... more

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Addressing childhood trauma in a developmental context

Gregorowski, C. & Seedat, S. Journal of Child and Adolescent Mental Health (2013) CC

Traditionally, understanding of the psychiatric and psychological effects of trauma have been developed from studies with adults and then applied t... more

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Guidance Note: IPC in Schools during AWD/Cholera Outbreaks

UN Children's Fund UNICEF; WASH Cluster (2023) C_UNICEF

WASH in schools during a cholera response is important due to the strong correlation between WASH and IPC. Not only can it impact the health and well-being of students ... staff but also facilitate the potential spread of the disease via the congregation of children and adults from multiple households. Hygiene can often be more difficult to control with young children and therefore efforts to put in place systems to encourage good practices are essential. To prevent the spread of cholera in schools, it is important to have clean and safe water sources, proper sanitation facilities, and good hygiene practices in place. This includes providing clean drinking water, hand-washing stations with soap, and education on hygiene and sanitation practices and implement Risk Communication and Community Engagement (RCCE) including dissemination of Information, Education and Communication materials (IEC). more

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Post-traumatic stress disorder: NICE guideline
recommended

National Institute for Health and Care Excellence (NICE) (2019) C1

NICE guideline | This guideline covers recognising, assessing and treating post-traumatic stress disorder (PTSD) in children, young people and .... It aims to improve quality of life by reducing symptoms of PTSD such as anxiety, sleep problems and difficulties with concentration. Recommendations also aim to raise awareness of the condition and improve coordination of care. more

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Rabies Vaccine

Center for Disease Control and Prevention CDC (2014) CC

A regimen of four 1-mL doses of HDCV or PCEC vaccines should be administered intramuscularly to previously unvaccinated persons. The first dose of the four-dose course should be administered as soon as possible after exposure. Additional doses should be administered on days 3, 7, ... 14 after the first vaccination. For adults, the vaccination should always be administered intramuscularly in the deltoid area (arm). For children, the anterolateral aspect of the thigh is also acceptable. The gluteal area should never be used for rabies vaccine injections because observations suggest administration in this area results in lower neutralizing antibody titers. more

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Current epidemiological evidence for predisposition to high or low intensity human helminth infection: a systematic review

Wright J.E., Werkman M., Dunn J.C. et al Parasites and Vectors (2018) C2

Background: The human helminth infections include ascariasis, trichuriasis, hookworm infections, schistosomiasis, lymphatic filariasis (LF) and onchocerciasis. It is estimated that almost 2 billion people worldwide are infected with helminths. Whils...t the WHO treatment guidelines for helminth infections are mostly aimed at controlling morbidity, there has been a recent shift with some countries moving towards goals of disease elimination through mass drug administration, especially for LF and onchocerciasis. However, as prevalence is driven lower, treating entire populations may no longer be the most efficient or cost-effective strategy. Instead, it may be beneficial to identify individuals or demographic groups who are persistently infected, often termed as being “predisposed” to infection, and target treatment at them. Methods: The authors searched Embase, MEDLINE, Global Health, and Web of Science for all English language, humanbased papers investigating predisposition to helminth infections published up to October 31st, 2017. The varying definitions used to describe predisposition, and the statistical tests used to determine its presence, are summarised. Evidence for predisposition is presented, stratified by helminth species, and risk factors for predisposition to infection are identified and discussed. Results: In total, 43 papers were identified, summarising results from 34 different studies in 23 countries. Consistent evidence of predisposition to infection with certain species of human helminth was identified. Children were regularly found to experience greater predisposition to Ascaris lumbricoides, Schistosoma mansoni and S. haematobium than adults. Females were found to be more predisposed to A. lumbricoides infection than were males. Household clustering of infection was identified for A. lumbricoides, T. trichiura and S. japonicum. Ascaris lumbricoides and T. trichiura also showed evidence of familial predisposition. Whilst strong evidence for predisposition to hookworm infection was identified, findings with regards to which groups were affected were considerably more varied than for other helminth species. Conclusion: This review has found consistent evidence of predisposition to heavy (and light) infection for certain human helminth species. However, further research is needed to identify reasons for the reported differences between demographic groups. Molecular epidemiological methods associated with whole genome sequencing to determine ‘who infects whom’ may shed more light on the factors generating predisposition. more

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The 2019 Global Multidimensional Poverty Index (MPI)

United Nations Development Programme (UNDP) and the Oxford Poverty and Human Development Initiative (OPHI) (2019) C1

This year’s MPI results show that more than two-thirds of the multidimensionally poor—886 millionpeople—live in middle-income countries. A further 440 million live in low-income countries. In both groups, data show, simple national averagescan hide enormous inequality inpatterns of povertywith... more

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WHEELCHAIR SERVICE TRAINING PACKAGE Participant's Workbook (Intermediate level)
recommended

Sarah Frost, Kylie Mines, Jamie Noon, Elsje Scheffler, and Rebecca Jackson Stoeckle WHO; USAID (2013) C_WHO

Following the release of the Wheelchair Service Training Package – Basic level (WSTP-B), WHO in partnership with United States Agency for International Development (USAID) has developed the Wheelchair Service Training Package – Intermediate Level (WSTP-I). WSTP-I is the second part of the WHO w... more

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EPI 5: Anti-epileptic medicines for medication resistant convulsive epilepsy. [New 2015]

mhGAP; WHO (2015) C_WHO

SCOPING QUESTION: For adults and children with medication-resistant convulsive epilepsy, which anti-epileptic medications produce benefits .../or harm in the specified outcomes when compared to a placebo or a comparator? more

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Tree of Life
recommended

Catholic Relief Services CRS, REPSSI (2018) C1

A workshop methodology for children, young people and adults The “Tree of Life” is a psychosocial support tool based on narrative practices th... more

Заболевание COVID-19 у детей и подростков Научная справка 29 сентября 2021 г.

World Health Organization WHO (2021) C_WHO

SARS-CoV-2 infections among children and adolescents cause less severe illness and fewer deaths compared to .... While a less severe course of infection is a positive outcome, there are concerns that mild symptoms may have led to less testing, resulting in fewer identified cases of COVID-19 in children. If children with mild or no symptoms transmit the disease, they may act as drivers of transmission within their communities. Understanding symptoms, infectivity and patterns of SARS-CoV-2 transmission in children and adolescents is essential for developing, adapting and improving control measures for COVID-19 across all ages. This is a summary of the current knowledge around SARS-CoV-2 infection acquisition and transmission and COVID-19 disease symptoms in children and adolescents. It aims to inform decisions, based on local contexts, on how to best keep schools, kindergarten and day-care facilities open and what advice to apply to intergenerational mixing. more

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Pneumonia kit 2020

World Health Organization WHO (2020) C_WHO

For 100 cases among which 60 cases of children ≥ 5 years old and 40 cases of children < 5 years old a... adults. The new Pneumonia kit 2020 is specially designed to provide sufficient child-size antibiotics to treat pneumonia, targeting children under 5 years of age. It aims to provide life-saving treatment based on the WHO protocols WHO treatment guidance Pneumonia should be treated with antibiotics. The antibiotic of choice is amoxicillin dispersible tablets. Most cases of pneumonia require oral antibiotics, which are often prescribed at a health centre. more

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Heart to Heart with My Child

International Organization for Migration IOM (2020) CC

One booklet is called "Heart-to-Heart with My Child." Published for Rohingya adults and children, it conveys key child protection messages in acces... more

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Реагирование на COVID-19: факторы, которые необходимо учесть в отношении детей и взрослых с инвалидностью

unicef UNICEF (2020) C_UNICEF

Что нам необходимо знать? Что нам необходимо делать? Рекомендации в отношении детей и взрослых с инвалидностью во времена Ковида Responding to COVID-19: factors to consider for ... and adults with disabilities more

Post-traumatic stress disorder: NICE guideline recommended

WHEELCHAIR SERVICE TRAINING PACKAGE Participant's Workbook (Intermediate level) recommended

Tree of Life recommended

Post-traumatic stress disorder: NICE guideline
recommended

WHEELCHAIR SERVICE TRAINING PACKAGE Participant's Workbook (Intermediate level)
recommended

Tree of Life
recommended