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Mpox Testing Strategy - November 2024

Africa Center for Disease Control and Prevention (2024) CC

Mpox is an emerging zoonotic disease caused by the mpox virus, a member of the Orthopoxvirus genus closely related to the variola virus that causes smallpox. Mpox was first discovered in 1958 when outbreaks of a pox-like disease occurred in monkeys kept for research. The first human case was recorde...d in 1970 in the Democratic Republic of the Congo (DRC) during a period of intensified effort to eliminate smallpox and since then the infection has been reported in a number of African countries. Mpox can spread in humans through close contact, usually skin-to-skin contact, including sexual contact, with an infected person or animal, as well as with materials contaminated with the virus such as clothing, beddings and towels, and respiratory droplets in prolonged face to face contact. People remain infectious from the onset of symptoms until all the lesions have scabbed and healed. The virus may spread from infected animals through handling infected meat or through bites or scratches. Diagnosis is confirmed by polymerase chain reaction (PCR) testing of material from a lesion for the virus’s DNA. Two separate clades of the mpox virus are currently circulating in Africa: Clade I, which includes subclades Ia and Ib, and Clade II, comprising subclades IIa and IIb. Clade Ia and Clade Ib have been associated with ongoing human-to-human transmission and are presently responsible for outbreaks in the Democratic Republic of the Congo (DRC), while Clade Ib is also contributing to outbreaks in Burundi and other countries. In 2022‒2023 mpox caused a global outbreak in over 110 countries, most of which had no previous history of the disease, primarily driven by human-to-human transmission of clade II through sexual contact. In just over a year, over 90,000 cases and 150 deaths were reported to the WHO. For the second time since 2022, mpox has been declared a global health emergency as the virus spreads rapidly across the African continent. On 13 Aug 2024, Africa CDC declared the ongoing mpox outbreak a Public Health Emergency of Continental Security (PHECS), marking the first such declaration by the agency since its inception in 2017.7 This declaration empowered the Africa CDC to lead and coordinate responses to the mpox outbreak across affected African countries. On August 14, 2024, the WHO declared the resurgence of mpox a Public Health Emergency of International Concern (PHEIC) emphasizing the need for coordinated international response. As of August 2024, Mpox has expanded beyond its traditional endemic regions, with new cases reported in countries including Sweden, Thailand, the Philippines, and Pakistan. Sweden has confirmed its first case of Clade 1 variant, which has been rapidly spreading in Africa, particularly in DRC. The emergence of this new variant raises concerns about its potential for higher lethality and transmission rates outside Africa. more

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Indonesia Environmental Service Program (ESP) Evaluation

USAID (2017) C1

WASH Ex-Post Evaluation Series - Water Communications and Knowledge Management (CKM) Project
This evaluation examines the sustainability of selected components of the USAID/Indonesia Environmental Services Program (ESP), which was implemented from 2004–2010. Among other objectives, this activ... more

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Quality Assurance Framework for SARS-CoV-2 Antigen Rapid Testing for Diagnosis of COVID-19
recommended

African Union; Africa CDC Centres for Disease Control and Prevention; AMREF; ASLM; et al. (2021) CC

ASLM in collaboration with the Africa Centres for Disease Control and Prevention, and in partnership with the Clinton Health Access Initiative, Amref and Last Mile Health present the Quality Assurance Framework for SARS-CoV-2 Antigen Rapid Testing for Diagnosis of COVID-19. This framework aims to pr... more

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Children and adolescents treated for post-traumatic stress disorder at the Free State Psychiatric Complex

Calitz, F.J., de Jongh, N.J., Horn, A., Nel, M.L. & Joubert, G. South African Journal of Psychology (2014) CC

Background. Children and adolescents can develop post-traumatic stress disorder (PTSD) after exposure to a range of traumatic events, including domestic, political or community violence, violent crime, physical and sexual abuse, hijacking, witnessing a violent crime and motor vehicle accidents. This... more

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How to Investigate Antimicrobial Use in Hospitals: Selected Indicators

USAID; Strengthening Pharmaceutical Systems (2008) C1

The purpose of this manual is to define a limited number of indicators that will objectively describe the management and use of antimicrobials in hospitals and to provide tools and step-by-step instructions for designing and carrying out an assessment of antibiotic use and management in hospitals. T... more

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MSF Essential Drugs - Practical Guidelines 2022
recommended

Médecins sans Frontières MSF Médecins sans Frontières (2022) C2

Practical guide intended for physicians, pharmacists, nurses and medical auxiliaries. This guide is not a dictionary of pharmacological agents. It is a practical manual intended for health professionals, physicians, pharmacists, nurses and health auxiliaries invoved in curative care and drug managem... more

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Untangling the Web of Antiretroviral Price Reductions. 18th edition

MSF Access Campaign Médecins Sans Frontières (2016) C3

This report provides an update on the key facets of HIV treatment access, including the latest HIV treatment guidelines from World Health Organization (WHO), an overview on pricing for first-line, second-line, and salvage regimens, and a summary of the opportunities for – and threats to – expand... more

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Single-Visit Approach to Cervical Cancer Prevention: Counseling Cue Cards

Pathfinder International (2013)

The single-visit approach to cervical cancer prevention (also referred to as the “See-and-Treat” approach) currently involves visual inspection of the cervix with acetic acid wash and treatment of precancerous lesions with cryotherapy. These cue cards are meant to be used with Pathfinder Intern... more

Medicinal products under development for the treatment of Ebola

European Medicines Agency EMA (2014)

Interim Assessement Report The EMA review was started by the Agency’s Committee for Medicinal Products for Human Use (CHMP) to support decision-making by health authorities. This first interim report includes information on seven experimental medicines intended for the treatment of people infecte... more

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West Africa - Ebola Outbreak, Fact Sheet #39, Fiscal Year (FY) 2015 (as of July 14, 2015)

US Agency for International Development, Centers for Disease Control and Prevention (2015)

The Government of Liberia (GoL) reports three additional EVD cases linked to the Margibi County cluster, including one in Liberia’s Montserrado County; new confirmed case total reaches six Recently extended Operation Northern Push strengthens contact tracing and EVD prevention activities ... more

National HIV/AIDS Programs - A Handbook on Supply Chain Management for HIV/AIDS Medical Commodities

Sangeeta Raja and Nadeem Mohammad ACTafrica, HNP (2005) C1

The handbook on supply chain management for HIV/AIDS commodities was written to assist program managers to plan and implement day–to-day management of all drugs and medical supplies for an HIV/AIDS program. Many of the suggested techniques described in this handbook are helpfu... more

Antimicrobials use, reistance and containment baseline survey (Ethiopia)

Drug Administration and Control Authority of Ethiopia , et al. (2009) C1

Emergence of antimicrobial resistance is a result of the use, overuse and misuse of antibiotics both in humans and animals. In Ethiopia, there are indications on the misuse of antibiotics by health care providers’, unskilled practitioners, and drug consumers. These coupled with rapid spread of res... more

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Free to be me

United Nations Children's Fund (UNICEF) (2013)

A comic book guide for young people on how to live happily and healthily with HIV in their lives. In this booklet, young people share their stories about living with HIV and staying healthy in Namibia today. You will find out everything you need to know about living happily and healthily with HIV. I... more

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Surveillance von Tuberkulose/HIV – ein Beispiel guter Praxis aus Botswana

Robert Koch Institut (2016) C1

Epidemiologisches Bulletin ; 12. Dezember 2016 / Nr. 49 aktuelle daten und informationen zu infektionskrankheiten und public health

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GLI Guide to TB Specimen Referral Systems and Integrated Networks

Global Laboratory Initiative (GLI), Stop TB Partnership (2018) C1

This guide includes information relevant for tuberculosis (TB) program and laboratory managers, as well as Ministry of Health officials across disease programs interested in establishing integrated solutions for specimen referral. Though TB-focused in name, it offers integration-oriented assessment,... more

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Guidelines on Community Nursing Services (CNS) provision in Kenya

Nursing Council of Kenya (2013) C1

Aims of the CNS programme:
- To provide accessibility to quality nursing care and related services including clinical assessment and personalized care for persons enrolled/entitled to CNS services.
- To enhance the independence and health outcomes of entitled persons by avoiding early admi... more

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Implications of differentiated care for successful ART scale up in a concentrated HIV epidemic in Yangon, Myanmar

Mesic, Anita; Fontaine, Julie; Theingy Aye et al. (2017) CC

Journal of the International AIDS Society 2017, 20(Suppl 4):21644
National AIDS Programme in Myanmar has made significant progress in scaling up antiretroviral treatment (ART) services and recognizes the importance of differentiated care for people living with HIV. Indeed, long centred around t... more

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Optimal timing of HIV home‐based counselling and testing rounds in Western Kenya

Olney, Jack J.; Eaton, Jeffrey W.; Braitstein, Paula et al. (2018) CC

Journal of the International AIDS Society, vol. 21 Issue no. 6 e 25142
Weaknesses in care programmes providing anti‐retroviral therapy (ART) persist and are often instigated by late HIV diagnosis and poor linkage to care. We investigated the potential for a home‐based counselling and testin... more

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Water, Sanitation and Hygiene (WASH) in Schools: Guidelines for Timor-Leste, Vol. 1

República Democrática de Timor-Leste (2016) C1

The development of water, sanitation and hygiene (WASH) in schools guidelines for TimorLeste is a landmark moment in our quest to make every school child-friendly – a place where every child can learn, play and grow with pride and dignity. The overarching goal is to improve health, boost education... more

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Desk Review & Recommendations for the Improvement of Early Warning Formulation and Dissemination/Communication in Myanmar

Myanmar DRR Working Group (2016) C1

No publication year indicated
In the context of the floods in August 2015 in Myanmar, the Disaster Risk Reduction Working Group (DRR WG) was requested to provide clear recommendations to the DMH (Department of Hydrology and Meteorology)to strengthen preparedness activities, in particular for t... more

Quality Assurance Framework for SARS-CoV-2 Antigen Rapid Testing for Diagnosis of COVID-19 recommended

MSF Essential Drugs - Practical Guidelines 2022 recommended

Quality Assurance Framework for SARS-CoV-2 Antigen Rapid Testing for Diagnosis of COVID-19
recommended

MSF Essential Drugs - Practical Guidelines 2022
recommended