Cryptococcal disease is one of the most common opportunistic infections among people living with advanced HIV disease and is a major contributor to severe illness, morbidity, and mortality, particularly in sub-Saharan Africa.
These guidelines update the recommendations that were first released i
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n 2018 on diagnosing, preventing, and managing cryptococcal disease. In response to important new evidence that became available in 2021, these new guidelines strongly recommend a single high dose of liposomal amphotericin B as part of the preferred induction regimen for the treatment of cryptococcal meningitis in people living with HIV. This simplified regimen - a single high dose of liposomal amphotericin B paired with other standard medicines (flucytosine and fluconazole) - is as effective as the previous WHO standard of care, with the benefits of lower toxicity and fewer monitoring demands.
The objective of these guidelines is to provide updated, evidence-informed recommendations for treating adults, adolescents and children living with HIV who have cryptococcal disease. These guidelines are aimed at HIV programme managers, policymakers, national treatment advisory boards, implementing partners and health-care professionals providing care for people living with HIV in resource-limited settings with a high burden of cryptococcal disease.
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Guidance has been updated on a number of chemicals: asbestos, bentazone, chromium, iodine, manganese, microcystins, nickel, silver, tetrachloroethene and trichloroethene. Guidance has also been added for chemicals not previously assessed in the Guidelines: anatoxin-a and analogues, cylindrospermopsi
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ns and saxitoxins. The new guidance on organotins has replaced the prior guidance focused on dialkyltins. With these updates, the guideline values for tetrachloroethene and trichloroethene have been revised while new guideline values for cylindrospermopsins, manganese, microcystins, and saxitoxins have been established .
Updated information on cyanobacteria has been included, introducing an alert level framework for early-warning and to guide short-term management responses. Guidance has also been updated in the sections on adequacy of water supply, climate change, emergencies, food production and processing, and radiological aspects, particularly on managing radionuclides when exceeding WHO screening values and guidance levels.
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Thailand is exposed to flooding, landslides, drought, earthquakes, tsunamis, heat waves, forest fires, and epidemics. Thailand is also exposed to technological hazards such as chemical accidents. Flooding is the natural hazard with the most significant impact on human life, livelihoods, and the econ
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omy for the country. The occurrence of droughts has increased in recent years due to the effects of the El Niño-Southern Oscillation (ENSO) cycle, which brings drier-than-average rainfall conditions. Drought has adversely impacted the country’s agriculture sector, which employs around one third of the country’s workforce.
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TB remains one of the world’s deadliest infectious diseases, second only to COVID-19, and drug-resistant TB strains are still a major concern. In the fight against TB, urgent investment is critical, especially in the context of the ongoing pandemic.
Alle Geflüchtete haben das Recht auf eine menschenwürdige Unterbringung und Schutz vor Gewalt. Bund und Länder sind dazu verpflichtet, einen angemessenen und wirksamen Schutz sicherzustellen. Für traumatisierte und besonders vulnerable Geflüchtete ist dies umso wichtiger. In den Unterkünften b
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raucht es daher sowohl ein Schutzkonzept vor Gewalt, als auch konkrete Leitlinien für die Mitarbeiter*innen, welche verdeutlichen, wie diese umzusetzen sind. Außerdem wurde der Praxisleitfaden zum „Traumasensiblen und empowernden Umgang mit Geflüchteten“ erstellt, der nicht nur für die Gewaltschutzkoordination bei der Umsetzung der Mindeststandards in den Unterkünften hilfreich ist, sondern auch für andere ehren- oder hauptamtlich arbeitende Personen Informationen und Handlungsvorschläge zu den Bereichen Trauma und Flucht bietet.
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While much of Myanmar’s population continues to benefit from the ongoing process of political and economic reforms, there are close to one million people who remain in need of emergency assistance and protection as a result of ongoing crises in Rakhine, Kachin and Shan. In addition, despite signif
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icant progress and investments in disaster risk reduction, millions of people in different parts of Myanmar face the ever-present risk of natural disasters in one of Asia’s most disaster-prone countries.
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The objective of this guideline is to present the complete set of all WHO recommendations and best practice statements relating to abortion. While legal, regulatory, policy and service-delivery contexts may vary from country to country, the recommendations and best practices described in this docume
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nt aim to enable evidence-based decision-making with respect to quality abortion care.
This guideline updates and replaces the recommendations in all previous WHO guidelines on abortion care
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10th edition
The IDF Diabetes Atlas 10th edition provides detailed information on the estimated and projected prevalence of diabetes, globally, by region, country and territory, for 2021, 2030 and 2045. It draws attention to the growing impact of diabetes across the world and highlights proven and
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effective actions that governments and policy-makers must urgently take to tackle it.
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Planetary health is a nascent concept focused on the interdependence of human, animal, and environmental health. It offers a new way to solve global problems, such as pollution and global food security, by balancing the health of our planet with human advancement.
Panorama is motivated by the audac
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ious and visionary concept of planetary health. It represents a tremendous opportunity to solve the biggest health and environmental problems of today.
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In the spirit of the Sustainable Development Goals, WHO and the International Labour Organization (ILO) produce the WHO/ILO Joint Estimates of the Work-related Burden of Disease and Injury (WHO/ILO Joint Estimates). The WHO/ILO Joint Estimates quantify the population exposed to occupational risk fac
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tors and amount health loss caused by these exposures. Global, regional and national estimates are produced of the numbers of deaths and disability-adjusted life years that can be attributed to exposure to selected occupational risk factors. Estimates are produced disaggregated by sex and age group.
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The Best practice portal is designed to help you find practical and reliable information on what works (and what doesn’t) in the areas of prevention, treatment, harm reduction and social reintegration. It will help you identify tried and tested interventions quickly, allocate resources to what's e
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ffective, and improve interventions applying tools, standards and guidelines.
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Continuing a worrying decade-long rising trend, the number of people forced to flee due to persecution, conflict, violence, human rights violations and events seriously disturbing public order climbed to 89.3 million by the end of 2021. This is more than double the 42.7 million people who remained f
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orcibly displaced at the end of 2012 and represents a sharp 8 per cent increase of almost 7 million people in the span of just 12 months. As a result, above one per cent of the world’s population – or 1 in 88 people – were forcibly displaced at the end of 2021. This compares with 1 in 167 at the end of 2012. During 2021, some 1.7 million people crossed international borders seeking protection and 14.4 million new displacements within their countries were reported. This is a dramatic increase from the combined 11.2 million a year earlier.
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Facing the global nutrition challenges, the World Health Organization (WHO) teamed up with the United Nations Institute for Training and Research (UNITAR) to design, under the guidance of the Department of Nutrition for Health and Development (NHD), a Nutrition Knowledge Hub. By building the techni
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cal and functional capacities of all relevant staff at WHO through e-learning courses and key nutrition-related training and knowledge materials, the Nutrition Knowledge Hub aims to contribute to the acceleration and increase of the nutrition impact at the country level. The Nutrition Knowledge Hub also offers free and open courses to reach a larger public and raise awareness on the malnutrition problem and WHO’s response.
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This website from the Planetary Health Alliance compiles information on who's doing what in planetary health education, general resources and thematic areas.
The RehApp is specifically designed for fieldworkers in low-and middle-income countries and aims to enhance their capacity to work with people with disabilities within the community: assess their abilities and inabilities, design rehabilitation interventions, provide care and support and refer appro
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priately. It consists of different chapters – covering various types of impairments – organised according to the International Classification of Functioning, Disability and Health, commonly known as the ICF.
The RehApp is available for free, and once downloaded, it can be used in any setting without internet access. It is currently available in English, French, Nepali, and Portuguese. Several chapters area also available in Amharic, Burmese, Khmer, Spanish, Tajik and Vietnamese. The App is available for Apple and for Android.
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Esta guía va dirigida a los profesionales de la salud que proporcionan asistencia curativa en dispensarios y hospitales. Hemos intentado responder a las preguntas y problemas con los que se enfrenta el personal sanitario, procurando dar soluciones prácticas y aunando la experiencia adquirida por M
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édicos Sin Fronteras en el terreno, las recomendaciones de organismos de referencia como la Organización Mundial de la Salud y aquellas obras especializadas en la materia.
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The booklet starts with a general overview of how illicit drugs and the environment are linked within the bigger picture of the Sustainable Development Goals, climate change and environmental sustainability. It highlights direct and indirect linkages and gives examples of the significant local and i
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ndividual-level impact that drugs can have on the environment. This is followed by a more in-depth overview of the latest scientific evidence for plant-based drugs and for synthetic drugs. For plant-based drugs, for example, this includes an analysis of the relationship between illicit crop cultivation and deforestation. For synthetic drugs, it includes an analysis of waste composition, volumes, and dumping and discharge, as well as the relation with wastewater treatment.
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