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Antimicrobial Resistance in Food-Animal Production INDIA OVERVIEW

Action on Anitbiotic Resistance (ReAct) (2018) C2

Indian markets caused a stir across the country.1 According to the Centre for Science and the Environment (CSE), a respected New Delhi-based NGO, most honey brands sold in India contained varying amounts of antibiotics. Their consumption over time could induce resistance to antibiotics, putting p... more

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Chagas Disease in Dogs: Transmission, Diagnosis, Treatment, and Prevention

Saunders, A. & Hamer, S. Today's Veterinary Practice (2020) CC

Chagas disease is caused by Trypanosoma cruzi, a protozoal organism primarily transmitted by triatomine insect vectors, also known as “kissing bugs.” It is a zoonotic disease originally described by Brazilian physician Dr. Carlos Chagas in 1909 and is widespread in Latin America. Although triato... more

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Leptospiral Infection, Pathogenesis and Its Diagnosis

Samrot, A.; Sean, T.; Bhavya, K.; et al. (2021) CC

Leptospirosis is a perplexing conundrum for many. In the existing literature, the pathophysiological mechanisms pertaining to leptospirosis is still not understood in full. Considered as a neglected tropical zoonotic disease, leptospirosis is culminating as a serious problem worldwide, seemingly exi... more

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An update on rabies in South Africa, 2021

National Institute for Communicable Disease NICD (2021) CC

As of 14 December 2021, a total of 19 laboratory-confirmed human rabies cases has been reported in South Africa for 2021. The cases are from Eastern Cape, KwaZuluNatal and Limpopo provinces. In addition, four probable rabies cases were reported from KwaZulu-Natal and the Eastern Cape provinces. A pr... more

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Chagas heart disease: An overview of diagnosis, manifestations, treatment, and care

Saraiva R.M., Mediano M.F.F., Mendes F.S. et al World Journal of Cardiology (WJC) (2021) C2

Chagas heart disease (CHD) affects approximately 30% of patients chronically infected with the protozoa Trypanosoma cruzi. CHD is classified into four stages of increasing severity according to electrocardiographic, echocardiographic, and clinical criteria. CHD presents with a myriad of clinical man... more

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Clinical Management of Yellow Fever in the Region of the Americas. Experiences and Recommendations for Health Services

Pan American Health Organisation PAHO (2023) CC

The waves of yellow fever transmission in the Region of the Americas in 2016–2018 involved the largest number of human and epizootic cases to be reported in several decades. Yellow fever is a serious viral hemorrhagic disease that poses a challenge for health professionals. It requires early recog... more

CVJ Africa

Cardiovascular Journal of Africa (2023) CC

The Cardiovascular Journal of Africa (CVJA) is an international peer-reviewed journal that keeps cardiologists up to date with advances in the diagnosis and treatment of cardiovascular disease. Topics covered include coronary disease, electrophysiology, valve disease, imaging techniques, congenital ... more

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HEARTS technical package for cardiovascular disease management in primary health care: risk based CVD management

World Health Organization WHO (2020) C_WHO

Development of cardiovascular disease (CVD) is influenced by risk factors such as: tobacco use, an unhealthy diet, physical inactivity, obesity (which can result from a combination of unhealthy diet, physical inactivity, and other factors), elevated blood pressure (hypertension), abnormal blood l... more

National User Guide on the Prevention and Treatment of Hypertension in Adults at the PHC Level 2021

Health Department: Republic of South Africa (2021) CC

Hypertension is referred to as a “silent killer”. Most people with hypertension are unaware of their condition as in most cases, they experience no warning signs or symptoms hence they are not identified or treated. Hypertention is associated with a number of conditions, disability, and causes o... more

Global Heart & Circulatory Diseases Factsheet

British Heart Foundation (2023) CC

Heart & Circulatory Diseases (Cardiovascular Disease; CVD) Heart and circulatory diseases is an umbrella term for all diseases of the heart and circulation. It includes everything from conditions that are inherited or that a person is born with, to those that develop later, such as coronary heart d... more

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Cardiovascular diseases in Africa in the twenty-first century: Gaps and priorities going forward

Minja, N.W.; Nakagaayi, D.; Aliku, T. et al. Frontiers in Cardiovascular Medicine (2022) CC

In 2015, the United Nations set important targets to reduce premature cardiovascular disease (CVD) deaths by 33% by 2030. Africa disproportionately bears the brunt of CVD burden and has one of the highest risks of dying from non-communicable diseases (NCDs) worldwide. There is currently an epide...miological transition on the continent, where NCDs is projected to outpace communicable diseases within the current decade. Unchecked increases in CVD risk factors have contributed to the growing burden of three major CVDs—hypertension, cardiomyopathies, and atherosclerotic diseasesleading to devastating rates of stroke and heart failure. The highest age standardized disability-adjusted life years (DALYs) due to hypertensive heart disease (HHD) were recorded in Africa. The contributory causes of heart failure are changing—whilst HHD and cardiomyopathies still dominate, ischemic heart disease is rapidly becoming a significant contributor, whilst rheumatic heart disease (RHD) has shown a gradual decline. In a continent where health systems are traditionally geared toward addressing communicable diseases, several gaps exist to adequately meet the growing demand imposed by CVDs. Among these, high-quality research to inform interventions, underfunded health systems with high out-of-pocket costs, limited accessibility and affordability of essential medicines, CVD preventive services, and skill shortages. Overall, the African continent progress toward a third reduction in premature mortality come 2030 is lagging behind. More can be done in the arena of effective policy implementation for risk factor reduction and CVD prevention, increasing health financing and focusing on strengthening primary health care services for prevention and treatment of CVDs, whilst ensuring availability and affordability of quality medicines. Further, investing in systematic country data collection and research outputs will improve the accuracy of the burden of disease data and inform policy adoption on interventions. This review summarizes the current CVD burden, important gaps in cardiovascular medicine in Africa, and further highlights priority areas where efforts could be intensified in the next decade with potential to improve the current rate of progress toward achieving a 33% reduction in CVD mortality. more

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South African cardiovascular risk stratification guideline for non-cardiac surgery

Alphonsus, C.; Naidoo, N.; Motshabi, P. et al. South African Medical Journal (2021) CC

The South African (SA) guidelines for cardiac patients for non-cardiac surgery were developed to address the need for cardiac risk assessment and risk stratification for elective non-cardiac surgical patients in SA, and more broadly in Africa. The guidelines were developed by updating the Canadian ...Cardiovascular Society Guidelines on Perioperative Cardiac Risk Assessment and Management for Patients Who Undergo Non-cardiac Surgery, with a search of literature from African countries and recent publications. The updated proposed guidelines were then evaluated in a Delphi consensus process by SA anaesthesia and vascular surgical experts. The recommendations in these guidelines are: 1. We suggest that elective non-cardiac surgical patients who are 45 years and older with either a history of coronary artery disease, congestive cardiac failure, stroke or transient ischaemic attack, or vascular surgical patients 18 years or older with peripheral vascular disease require further preoperative risk stratification as their predicted 30-day major adverse cardiac event (MACE) risk exceeds 5% (conditional recommendation: moderate-quality evidence). 2. We do not recommend routine non-invasive testing for cardiovascular risk stratification prior to elective non-cardiac surgery in adults (strong recommendation: low-to-moderate-quality evidence). 3. We recommend that elective non-cardiac surgical patients who are 45 years and older with a history of coronary artery disease, or stroke or transient ischaemic attack, or congestive cardiac failure or vascular surgical patients 18 years or older with peripheral vascular disease should have preoperative natriuretic peptide (NP) screening (strong recommendation: high-quality evidence). 4. We recommend daily postoperative troponin measurements for 48 - 72 hours for non-cardiac surgical patients who are 45 years and older with a history of coronary artery disease, or stroke or transient ischaemic attack, or congestive cardiac failure or vascular surgical patients 18 years or older with peripheral vascular disease, i.e. (i) a baseline risk >5% for MACE 30 days after elective surgery (if no preoperative NP screening), or (ii) an elevated B-type natriuretic peptide (BNP)/N-terminal-prohormone B-type natriuretic peptide (NT-proBNP) measurement before elective surgery (defined as BNP >99 pg/mL or a NT-proBNP >300 pg/mL) (conditional recommendation: moderate-quality evidence). Additional recommendations are given for the management of myocardial injury after non-cardiac surgery (MINS) and medications for comorbidities. more

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Cardiovascular Diseases in Sub-Saharan Africa Compared to High-Income Countries: An Epidemiological Perspective

Yuyun, M.F.; Sliwa, K.; Kengne, A.P. et al. Global Heart (2020) CC

Non-communicable diseases (NCDs) are the second common cause of death in sub-Saharan Africa (SSA) accounting for about 35% of all deaths, after a composite of communicable, maternal, neonatal, and nutritional diseases. Despite prior perception of low NCDs mortality rates, current evidence suggests t... more

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Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association

Tsao, C.W.; Aday, A.W.; Almarzooq, Z.I. et al. Circulation (2022) CC

The American Heart Association, in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, diet, and weight) and health factors ... more

Diabetes Key Facts

World Health Organization Africa WHO (2014) C_WHO

The number of people with diabetes has risen from 108 million in 1980 to 422 million in 2014. The global prevalence of diabetes* among adults over 18 years of age has risen from 4.7% in 1980 to 8.5% in 2014. Diabetes prevalence has been rising more rapidly in middle- and low-income countries. Dia... more

Diabetes WHO - Arabic version

World Health Organisation (WHO) World Health Organization (WHO) (2023) C_WHO

The World Health Organization's fact sheet on diabetes provides an overview of the disease, highlighting its increasing prevalence, particularly in low- and middle-income countries. It outlines the main types of diabetes—Type 1, Type 2, and gestational diabetes—detailing their characteristics an... more

Diabetes WHO - Chinese version

World Health Organisation (WHO) World Health Organization (WHO) (2023) C_WHO

Cardiovascular Journal of Africa

Cardiovascular Journal of Africa (2024) CC

Cystic fibrosis on the African continent

Stewart, C.; Pepper, M. (2015) CC2

Our awareness necessity of cystic fibrosis (CF) significantly predates our ability to comprehend the molecular factors that underpin its cause and affect prognosis. The dire warning “Woe to that child which when kissed on the forehead tastes salty. He is bewitched and soon must die” has been cir... more

Burden of asthma and chronic obstructive pulmonary disease and access to essential medicines in low-income and middle-income countries

The Lancet Respiratory Medicine (2015) CC2

Demographic and epidemiological transitions are changing the age structure of the population and the most common diseases. Non-communicable respiratory diseases are an increasing problem at both ends of the age range in low-income and middle-income countries. In children, who represent a large propo... more