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Submitted to the US Agency for International Development by the Systems for Improved Access to Pharmaceuticals and Services (SIAPS) Program.

Controlled clinical trails in Tuberculosis

A. Jindani, A. Nunn, D. A. Enarson International Union Against Tuberculosis and Lung Disease (2004)
A Guide For Multicentre Trials in High-Burden Countries
Year one report
54th directing council; 67th session of the regional Committee of WHO for the Americas CD54/11, Rev. 1, 2 October 2015, Original: Spanish
Research Article BMC Infectious Diseases 2012, 12:262; doi:10.1186/1471-2334-12-262
17–24 November 2015
4–15 February 2013
Report of a mission 20–24 April 2015
PLOS ONE | www.plosone.org September 2014 | Volume 9 | Issue 9 | e103657
The National Tuberculosis Programme (NTP) of Rwanda (known as TB & ORD Division/IHDPC/RBC) is preparing to write their next National Strategic Plan and for this reason Rwanda was selected as a country to received technical assistance (TA) to conduct an assessment of their surveillance system using t ... more
These guidelines have been developed to provide guidance to the Ministry of Health in managing applications for registration of human pharmaceutical products in Rwanda. It was compiled by the Technical Working Group (TWG) on Medicines Evaluation and Registration (MER) of the East African Community M ... more
The purpose of these guidelines is to help health workers to participate in the process of continuous surveillance of safety and efficacy of the pharmaceutical products which are used in clinical practice, thus help to achieve the ultimate goal to make safer and more effective treatment available to ... more
This document describes the key areas that national governments should consider for the introduction and scale-up of point-of-care (POC) diagnostics within national programmes, as new innovative POC technologies are being introduced into the market. The next steps taken to include these new innovati ... more
Recent systematic reviews and meta-analysis of the impact of chemical-based mollusciciding (King et al., 2015, Sokolow et al., 2016) have concluded that regular mollusciciding is likely to contribute significantly towards elimination of schistosomiasis in high-risk areas. The WHO roadmap’s new foc ... more
This year marked the beginning of the WHO biennium 2016-2017 action plan; this annual report highlights WHO’s key achievements in 2016 It also documents the extraordinary efforts by a broad coalition of government ministries, municipalities, international agencies, community groups, women’s or ... more
Operational Guidelines
The International Journal of Tuberculosis and Lung Disease 21(5) DOI: 10.5588/ijtld.16.0518
The guidelines reiterate that the general principles of ethics for biomedical research involving human participants shall also be applicable. In addition, the guidelines specify unique provisions for stem cells, because of their inherent property for unlimited proliferation, differentiation to cells ... more
This treatment guideline is intended to assist clinicians in the Behavioral Health department in treatment planning and service delivery for patients with Post Traumatic Stress Disorder (PTSD). It may also assist clinicians treating patients who have some of the signs and symptoms of PTSD but who do ... more
Published: 5 January 2010 Received: 30 January 2009 BMC Neurology 2010, 10:1 doi:10.1186/1471-2377-10-1 This article is available from: http://www.biomedcentral.com/1471-2377/10/1
Ausgehend von allgemeinen Informationen zum Land über Hintergrundinformationen zum Konflikt (Wirtschaftskrise und politische Krise) werden auch die Menschenrechtsverletzungen durch die Regierung beschrieben. Der Bericht geht in diesem Zusammenhang auf die Aktivitäten der zahlreichen bewaffneten Gr ... more
Куріння, вживання алкоголю та наркотичних речовин серед підлітків, які навчаються: поширення й тенденції в Україні : За результатами дослідження 2015 року в рамках м ... more

WHO mhGAP Guideline update

WHO WHO (2015) C_WHO
Update of the Mental Health Gap Action Programme (mhGAP) Guideline for Mental, Neurological and Substance use Disorders May 2015
Externalising disorders Chapter D.2
Anxiety disorders Chapter F.5
Psychiatry and Pediatrics Chapter I.4
Introduction Capter A.1 Ethics and international child and adolescent psychiatry
BMC Public Health, Volume 18, Article number: 303 (2018) https://doi.org/10.1186/s12889-018-5208-0 Published: 02 March 2018
Meeting Report Bangkok, Thailand 8-11 August 2016
UNAIDS/99.31E (English original, June 1999) 1st revision, April 2000

Prevention Gap Report

UNAIDS; AIDSinfo (2016) C2
Joint United Nations Programme on HIV/AIDS
A case study from Bosnia and Herzegovina Eurasian Harm Reduction Network The case study was prepared by Samir Ibisevic, President of PROI between March and June 2016 and edited by Graham Shaw. EHRN is grateful to all who contributed to this document, especially: Dr. Serifa Godinjak, Chairperson ... more
A case study from Albania June 2016 EHRN is grateful to all who contributed to this document, especially (in alphabetical order): Alena Alba, Program Officer, Eastern Europe and Central Asia Team, Asia, Europe, Latin America and the Caribbean Department, The Global Fund to Fight AIDS, Tuberc ... more
Research Article Hindawi Publishing Corporation AIDS Research and Treatment Volume 2011, Article ID 621078, 7 pages doi:10.1155/2011/621078
Original Article SAGE Open Medicine Volume 5: 1–7 © The Author(s) 2017 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav httpDs:O//dIo: i1.o0r.g1/107.171/2770/52035013212171773311977 journals.sagepub.com/home/smo

HIV Programme Review in Georgia

J. V. Lazarus; A. Sönnerborg; H. Fuenzalida; E. Subata World Health Organization (Europe); Centre for Health & Infectious Disease Research (2015) C_WHO
March 2015

JPS 2012-2016

UNAIDS (2019) C2
Zero new HIV infections Zero Discrimination Zero AIDS related deaths Accessed: 04.10.2019
MSF provides treatment for HIV and tuberculosis (TB) in more than 20 countries around the world. The report Burden sharing or burden shifting? How the HIV/TB response is being derailed examines the situation in nine countries where MSF runs programmes: Central African Republic, Democratic Republic ... more
J Acquir Immune Defic Syndr  Volume 78, Supplement 1, August 15, 2018

Stigmatization and Discrimination toward People Living with HIV/AIDS in a Coastal City of South India

N. Kumar; B. Unnikrishnan; R. Thapar Journal of the International Association of Providers of AIDS Care; SAGE Journals (2017) C2
Journal of the International Association of Providers of AIDS Care 2017, Vol. 16(3) 226–232

Annex 3. Dosages of ARV drugs

World Health Organization (2019) C_WHO
Accessed: 19.10.2019
Supplement Article www.jaids.com J Acquir Immune Defic Syndr  Volume 78, Supplement 1, August 15, 2018

Factors associated with depression among HIV/AIDS children in China

E. Zhou; Z. Qiao; Y. Cheng; et al. International Journal of Mental Health Systems; BioMed Central (2019) CC
Zhou et al. Int J Ment Health Syst (2019) 13:10 https://doi.org/10.1186/s13033-019-0263-1

Effective Laws to End HIV and AIDS: Next Steps for Parliaments

V. Oakeshott; L. Davies; T. Khumalo; et al. Inter-Parliamentary Union (For democracy, For everyone); UNDP (Empowered lives, Resilient nations) (2013) C2
International Journal of Infectious Diseases 80 (2019) 10–15 journal homepage: www.elsevier.com/locate/ijid
Research Article PLOS ONE | DOI:10.1371/journal.pone.0164619 October 13, 2016
HIV i-Base July 2018
Technical Update HIV Treatment July 2017
Patients with retreatment tuberculosis (TB) represent those who have been treated previously for onemonth ormorewith anti-TB drugs and who have been diagnosed once again with the disease.These patientsmainly include relapses, treatment after failure, or loss to follow-up on a first-line treatmen ... more
Research Article Hindawi BioMed Research International Volume 2018, Article ID 9619684, 10 pages https://doi.org/10.1155/2018/9619684
Nature Reviews Microbiology Vol. 17 (2019)pp.51-62 Antimicrobial susceptibility testing (AST) technologies help to accelerate the initiation of targeted antimicrobial therapy for patients with infections and could potentially extend the lifespan of current narrow- spectrum antimicrobials. Althoug ... more

Monitoring HIV impact using population-based surveys

UNAIDS (Joint United Nations Programme on HIVAIDS); World Health Organization (WHO) UNAIDS (Joint United Nations Programme on HIVAIDS); World Health Organization (WHO) (2015) C2
UNAIDS/WHO Working group HIV/AIDS and STI surveillance 2015 / Reference
1st edition This resource provides practical guidance for front line health workers responsible for the diagnosis, management and care of patients with these two diseases. Published in collaboration with the World Diabetes Foundation
The Antimicrobial Resistance Benchmark has evaluated for the second time how the most important players in the antibiotic market are addressing the rise of resistance and the global need for appropriate access to antibiotics. Although we can see progress — it’s hanging by a thread. We have reac ... more
Unstable settings present challenges for the effective provision of antiretroviral treatment (ART). In this paper, we summarize the experience and results of providing ART and implementing contingency plans during acute instability in the Central African Republic (CAR) and Yemen.
Antimicrobial resistance (AMR) is a serious public health concern with economic, social and political implications that are global in scope, and cross all environmental and ethnic boundaries. As a global threat, AMR risks the achievements of modern medicine, and has the po ... more
The Ghanaian Cabinet approved the antimicrobial resistance (AMR)Policy and Implementation plan(hereafter referred to as the national action plan or NAP)in December 2017, whilst the country case study was in progress. This has set in motion the implementation phase for Ghana, which is a long awaited ... more
This document updates the 2014 Core Elements for Hospital Antibiotic Stewardship Programs and incorporates new evidence and lessons learned from experience with the Core Elements. The Core Elements are applicable in all hospitals, regardless of size. There are suggestions specific to small and criti ... more
Methicillin-resistant Staphylococcus aureus(MRSA) strainsor multidrug-resistant S.aureus, initially described in 1960s,emerged in the last decade as a cause of nosocomial infections responsible for rapidly progressive, potential fatal diseases including life-threatening pneumonia, necrotizing fascii ... more
Global actions to reduce antimicrobial resistance (AMR) include optimising the use of antimicrobial medicines in human and animal health. In countries with weak healthcare regulation, this requires a greater understanding of the drivers of antibiotic use from the perspective of providers and consume ... more

Situation Analysis and Recommendation: Antibiotic Use and Resistance in Tanzania

Aboud S., R. Mdegela Global Antibiotic Resistance Partnership—Tanzania Working Group (2015) C2
Antibiotics and other antimicrobial agents are invaluable life savers, particularly in resource-limited countries where infectious diseases are abundant. Both uncomplicated and severe infections are potentially curable as long as the aetiological agents are susceptible to the ... more
Antimicrobial resistant (AMR) organisms are increasing globally, threatening to render existing treatments ineffective against many infectious diseases. In Africa, AMR has already been documented to be a problem for HIV and the pathogens that cause malaria, tuberculosis, typhoid, cholera, meningitis ... more
The purpose of these guidelines is to give practical advice to doctors so that all services and models of care used by doctors and health workers are encouraged to consider the use of telemedicine as a part of normal practice. These guidelines will assist the medical practitioner in pursuing a sound ... more
9 April 2020 WHO has published the guidance “Clinical management of severe acute respiratory infection (SARI) when COVID-19 disease is suspected” This document is intended for clinicians taking care of hospitalized adult and paediatric patients with severe acute respiratory infection (SARI) whe ... more
The Global Fund’s product and delivery outlook shows the overall impact of COVID-19 on health product supply chains for Global Fund grants has increased from "low to moderate" to "moderate."
Oxygen is an essential medicine required at all levels of the health care system; only high quality, medical-grade oxygen should be given to patients. Pressure swing adsorption (PSA) oxygen generating plants are a source of medical-grade oxygen. This document provides technical specifications as th ... more
Volume 2019, Article ID 4157574, 7 pages https://doi.org/10.1155/2019/4157574
The document "Priority medical devices list for the COVID-19 response and associated technical specifications" complements this guideline. This document provides interim guidance on the quality, performance characteristics and related standards of personal protective equipment (PPE) to be used i ... more
The conduct of COVID-19 vaccine trials in the context of a candidate vaccine being issued with Emergency Use Designation raises challenging ethical questions, including in relation to the use of placebo controls and unblinding of trial participants in current and future COVID-19 vaccine trials. This ... more
Vatican lays out 20 points for a universal and fair destination of vaccines, for a fairer and healthier world
Taking the whole of Africa approach to fighting the COVID-19 pandemic has and will continue to require coordinated efforts from multiple stakeholders from across the continent. Africa CDC would like to acknowledge the deep partnership and continued support of AUDA-NEPAD, AVAREF, WHO AFRO, the Bill a ... more
21.12.2020 Available in English, Spanish, Italian and Portuguese
This report challenges policy-makers and political leaders to tackle fossil fuel production and consumption as a health control issue, in the same way that smoking has been reduced and regulated. Fossil fuel combustion is a major source of toxic air pollution that kills 7 million people every year, ... more
Annex 5, WHO Technical Report Series 1010, 2018
The Kenyan Health Sector has been playing a critical role in providing health care services in response to the population needs in line with the Kenya Health Policy, 2014-2030’s goal of attaining the highest possible health standards in a manner responsive to the population needs.
Good Manufacturing Practice (GMP) describes a set of principles and procedures that, when followed, ensure that medicines and related substances are of high quality, safety and efficacy. SAHPRA is a participating authority of the Pharmaceutical Inspection Cooperation Scheme (jointly known as PIC/S) ... more
While COVID-19 virus continues to circulate and evolve, new variants are constantly emerging. Most of the current COVID-19 cases are driven by the circulation of the BA.5 subvariant of Omicron. The COVID-19 vaccines are being updated with Omicron variants to provide broader immunity against circulat ... more
The report aims to capture lessons from the COVID-19 pandemic and to highlight the opportunity for more ambitious global action: expanding sustainable access to vaccines for all towards the Immunization Agenda 2030 and pandemic prevention, preparedness and response efforts. The report is organized ... more
In response to the recent publication “Is onchocerciasis elimination in Africa feasible by 2025: a perspective based on lessons learnt from the African control programmes” by Dadzie et al., it is important to clarify and highlight the positive and unequivocal research and operational contributio ... more
Many low- and middle-income countries (LMICs) are undergoing an epidemiological transition. With an improvement in socioeconomic conditions and an aging population, cardiovascular diseases (CVDs), like cardiac arrhythmias, are expected to increase in these countries. However, there are limited studi ... more
Malawi is a landlocked country with a surface area of 118,484 km2. Administratively, the country is divided into three regions, namely the Northern, Central and Southern regions. The country has 28 districts, which are further divided into traditional authorities (TA) ruled by chiefs. The TAs are su ... more
Time has seen management for Cystic Fibrosis (CF) advance drastically, most recently in the development of the disease-modifying triple combination therapy ivacaftor/tezacaftor/elexacaftor. There is currently limited evidence regarding both the global epidemiology of CF and access to this transforma ... more
Provide guidance to HIV care practitioners on the optimal use of antiretroviral (ARV) agents for the treatment of HIV infection in adults and adolescents.