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An evaluation of the prescribing patterns for under-five patients at a Tertiary Paediatric Hospital in Sierra Leone. J Basic Clin Pharma 2015;6:109-14.
Antimicrobial resistance (AMR) is an increasing worldwide public health problem with important implications for the European Union (EU). When antibiotics become ineffective, bacterial infections lead to increased morbidity, use of healthcare, mortality and cost. Globally, estimates suggest that ... more

Tuberculosis. Diagnostics Technology Landscape. 5th edition

UNITAID World Health Organisation (WHO) (2017) C2
Accessed Oktober 18, 2017
The objective of this guidance document is to support the public health professionals in implementing effective surveillance of cholera in at-risk, endemic and epidemic areas. This document has been developed by the Surveillance Working Group of the Global Task Force for Cholera Control (GTFCC) a ... more
3rd edition
Lancet Planet Health 2017 Published Online November 6, 2017 http://dx.doi.org/10.1016/S2542-5196(17)30141-9
Mission report: June 11-20, 2017

Fever Diagnostic Technology Landscape

UNITAID World Health Organisation (WHO) (2018) C_WHO
1st edition. Unitaid’s report describes a slate of new devices that can more efficiently identify dangerously ill children so that they can be treated immediately. These tools make it easier to recognize danger signs, and support integrated approaches to reducing childhood deaths from the three ... more
This manual provides practical guidelines for the management of children with severe malnutrition. It seeks to promote the best available therapy so as to reduce the risk of death, shorten the length of time spent in hospital, and facilitate rehabilitation and full recovery. Emphasis is given to the ... more
This pocket guide offers basic information needed for the medical management of victims of radiation incidents in an easy-to-understand manner.

A Decision Makers Guide: Medical Planning and Response for a Nuclear Detonation

U.S. Department of Health & Human Services (2017) C1
Successful detonation of an improvised nuclear device (IND) would be a catastrophic event, causing an unprecedented number of injuries and lives lost, as well as economic, political, and social disruption. However, an effective medical response and an infrastructure prepared to protect itself from f ... more
Draft version 2017
Third edition. The main changes within the third edition of the JEE tool include the split of the technical area National legislation, policy, and financing into two technical areas (Legal instruments and Financing); the drop of the technical area previously titled Reporting and the move of indicat ... more
This working paper was conceived to offer practical tips and suggestions on how to establish and sustain the multisectoral coordination needed to develop and implement National Action Plans on AMR (NAPs). It is intended for anyone with responsibility for addressing AMR at country level. Drawing on b ... more
Standard Operating Procedures | RBC/IHDPC/EID Division | 9/30/2011
Conducted November 2011 to February 2012: Summary Report
This summary report has five sections. Following the introduction (Section 1), Section 2 sets out summary findings and recommendations of the assessment team. Section 3 describes the context in which artemisinin resistance is being tackle ... more
The report reflects on the trends, achievements and challenges in global health over the past decade during which Dr Margaret Chan has been Director-General of WHO. It discusses the role of WHO in dealing with such issues as the rise of noncommunicable diseases, leaps in life expectancy, and emergin ... more
The current guidelines on Integrated Management of Acute Malnutrition (IMAM), addresses the issue of improved management of severe acute malnutrition (SAM), particularly in children under 5 years of age. In the absence of standard protocols, mortality in children admitted to hospital with SAM can ra ... more
This document was prepared in response to a need to review and potentially update the current recommendations for the antibiotic treatment of both inpatient and outpatient management of severe acute malnutrition (SAM). The current recommendations (Table 1) are based on guidelines published in 2013 i ... more
The purpose of this document is to present and promote the minimum requirements for IPC programmes at the national and health care facility level, identified by expert consensus according to available evidence and in the context of the WHO core components. The minimum requirements are defined as: I ... more
Journal of The Association of Physicians of India, Vol. 63 November 2015,, pp.77-96
Formularies are lists of antibiotics that are suggested for certain healthcare settings. In developing a recommended formulary, countries should consider the needs of patients and facilities where they receive care. For example, clinicians in rural or primary health centers may need wide access to f ... more
It provides insight into WHO’s work that aims to improve the health of the people of the United Republic of Tanzania in collaboration with key stakeholders.
These guidelines have been developed for scientific purpose with the main aim to guide the regulatory authority for evaluating probiotic products in our country.
African Journal of Laboratory Medicine | Vol 7, No 2 | a770 | 06 December 2018
Antimicrobial resistance is one of the most important threats to the health worldwide. Antimicrobial resistance or drug resistance is the reduction of the pharmaceutical effects of a drug against a disease or reduction of its effectiveness in improving the clinical signs of a disease. Antimicrobial ... more
This paper focuses on the Sustainable Development Goals related to poverty, economic growth, inequality, health, food production and the environment. It presents concrete examples of the underlying and complex aspects of antibiotic resistance and its impacts across different Sustainable Development ... more

Developmental Disabilities

Institute of Medicine (US); Committee on Nervous System Disorders in Developing Countries; National Academy of Sciences (2001) C2
Neurological, Psychiatric, and Developmental Disorders: Meeting the Challenge in the Developing World Institute of Medicine (US) Committee on Nervous System Disorders in Developing Countries. Washington (DC): National Academies Press (US); 2001.
Deeply concerned by the morbidity and mortality caused by the COVID-19 pandemic, the negative impacts on physical and mental health and social well-being, the negative impacts on economies and societies and the consequent exacerbation of inequalities within and between countries. ... more
The Infection Prevention and Control (IPC) Assessment Framework (IPCAF) is a tool to support the implementation of the World Health Organization (WHO) Guidelines on core components of IPC programmes at the acute health care facility level. The user should be familiar with the contents of these guide ... more
WHO’s Essential Medicines List and List of Essential Diagnostics are core guidance documents that help countries prioritize critical health products that should be widely available and affordable throughout health systems. The updated Essential Medicines List adds 23 medicines for children.
Ethiopia Antimicrobial Resistance Surveillance Plan
6th edition
(Published with Decision No. 3003/Qð­BYT dated 19/8/2009 of the Minister of Health)
The objective of this briefis to set outlinkages between food safety and the Sustainable Development Goals(SDGs), to identify priority issues,and to suggest how investments in food safety can help attain SDGs.

TB and HIV concept note - Investing for impact against tuberculosis and HIV

The Global Fund To fight AIDS, Tuberculosis and Malaria (2015) C2
Single TB and HIV Concept Note Albania 2016-2018 27 April 2015
The overall objective of the Global Action Plan is to enhance collaboration among 12 global organizations engaged in health, development and humanitarian responses to accelerate country progress on the health-related SDG targets. The Plan presents a new approach to strengthening collaboration among ... more
В настоящем отчете (это уже четвертое его издание) анализируются препятствия и факторы, затрудняющие доступ к препаратам для лечения лекарственно-устойчивого туб ... more

Special edition: HIV in MSM

I. Steffens; K. Hagmaier; K. Wilson; et al. Eurosurveillance (Europe’s journal on infectious disease epidemiology, prevention and control); European Centre for Disease Prevention and Control (2015) C2
Eurosurveillance Impact Factor 5.7 June 2015 www.eurosurveillance.org Featuring a series of articles on HIV and STI epidemiology, prevention and control among MSM in Europe

56o Conselho director - 70a sessão do comitê regional da OMS para as Américas

Organização Pan-Americana da Saúde; Organização Mundial da Saúde (Américas) (2018) C_WHO
Tema 8.22 da agenda provisória Washington, D.C., EUA, 23 a 27 de setembro de 2018 CD56/INF/22 31 de agosto de 2018 Original: inglês/espanhol

56.o consejo directivo - 70.a sesión del comité regional de la OMS para las Américas

Organización Panamericana de la Salud; Organización Mundial de la Salud (Americas) (2018) C_WHO
Washington, D.C., EUA, del 23 al 27 de septiembre del 2018 Punto 8.22 del orden del día provisional CD56/INF/22 31 de agosto del 2018 Original: inglés/español

56th directing council - 70th session of the regional committee of WHO for the Americas

Pan American Health Organization; World Health Organization (Americas); Observatorio Regional de Recursos Humanos de Salud (2018) C_WHO
Washington, D.C., USA, 23-27 September 2018 Provisional Agenda Item 4.6 CD56/10, Rev. 1 31 August 2018 Original: Spanish

Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV.

AIDSinfo; CDC Centers for Disease Control and Prevention; National Institutes of Health; et al. (2019) C2
Downloaded from https://aidsinfo.nih.gov/guidelines on 11/27/2019 Visit the AIDSinfo website to access the most up-to-date guideline. Register for e-mail notification of guideline updates at https://aidsinfo.nih.gov/e-news.
The GAP articulates five objectives for tackling AMR, and sets out the tasks required to achieve them, highlighting roles and responsibilities for country governments, the One Health Tripartite organizations (FAO, OIE and WHO) and other national and international partners. To ensure that all stakeh ... more
Accessed Febr. 6, 2020
Accessed Febr. 6, 2020
Accessed Febr. 6, 2020
The global tripartite self-assessment survey of country progress in addressing antimicrobial resistance (AMR) is a component of a broader approach for monitoring and evaluation of the global action plan on AMR. This report analyses the results of the second tripartite self-assessment survey
Textes du Codex concernant la résistance aux antimicrobiens d’origine alimentaire Textos del Codex sobre la resistencia a los antimicrobianos transmitida por los alimentos Antimicrobial resistance (AMR) is a major global public health concern and a food safety issue. When pathogens become r ... more
The Antimicrobial Resistance Benchmark has evaluated for the second time how the most important players in the antibiotic market are addressing the rise of resistance and the global need for appropriate access to antibiotics. Although we can see progress — it’s hanging by a thread. We have reac ... more
Antibiotic resistant bacteria are spreading at an alarming rate and some bacterial infections may once again be untreatable. Antibiotic resistance (ABR), conservatively calculated, causes more than 500 000 deaths every year. This number is projected to rise dramatically if radical actions are not ta ... more
Antibiotic resistant bacteria are spreading at an alarming rate and some bacterial infections may once again be untreatable. Antibiotic resistance (ABR), conservatively calculated, causes more than 500 000 deaths every year. This number is projected to rise dramatically if radical actions are not ta ... more
Antibiotic resistant bacteria are spreading at an alarming rate and some bacterial infections may once again be untreatable. Antibiotic resistance (ABR), conservatively calculated, causes more than 500 000 deaths every year. This number is projected to rise dramatically if radical actions are not ta ... more
Food safety and antimicrobial resistance research: A One Health perspective. Presented at the Emerging Pathogens Institute Seminar Series, Gainesville, Florida, 26 July 2019
Scientists have known for more than half a century that patients could develop resistance to the drugs used to treat them. Alexander Fleming, who is credited with creating the first antibiotic, penicillin, in 1928, cautioned of the impending crisis while accepting his Nobel prize in 1945: “There ... more
The global tripartite self-assessment survey of country progress in addressing antimicrobial resistance (AMR) is a component of a broader approach for monitoring and evaluation of the global action plan on AMR. This report analyses the results of the second tripartite self-assessment survey. It has ... more
This manual for developing national action plans to address antimicrobial resistance has been developed at the request of the World Health Assembly to assist countries in the initial phase of developing new, or refining existing national action plans in line with the strategic objectives of the Glo ... more
AMR is a serious and growing global problem. A WHO report released in 2014 stated that this serious threat is no longer a prediction for the future it is happening now in every region of the world and has potential to affect anyone, of any age in any community – a real threat to the public health. ... more
This National Action Plan addresses actions needed to be taken in order to combat antimicrobial resistance (AMR) in the country. It is obligatory to raise awareness of antimicrobial resistance and promote behavioral change through public communication programmes that targets human, animal and plant ... more
Antimicrobial agents play an indispensable role in animal health and welfare management. At the same time, the need for prudent use is obvious to ensure good food safety outcomes and to manage the potential risk of antimicrobial resistance. The emergence of multi-resistant bacteria is posing challen ... more
As the number of transboundary pest and animal and foodborne disease outbreaks rises, so does the number of people who are chronically hungry due to these and other factors. The correlation can be explained by the link between our health and that of the planet. We rely on land and sea for the produc ... more
MICROBIAL DRUG RESISTANCEVolume 24, Number 5, 2018ªMary Ann Liebert, Inc.DOI: 10.1089/mdr.2017.0383 Antibiotic resistance (ABR) is a worldwide publichealth concern, with serious health, economic, and so-cietal repercussions. Its emergence is attributed to the se-lective pressure exerted by antib ... more
This book provides significantly expanded content and experience in relation to a broader stewardship context- for example, stewardship in specific populations, different countries as well as the role of different professions in stewardship to political and media engagement. We hope this book has so ... more
The systematic surveillance of antibiotic use and antibiotic re-sistance prevalence in humans and animals is imperative for managingbacterial infectious disease (JPIAMR, 2019;WHO, 2015). Many low-income countries currently face substantial challenges in building national surveillance systems due to ... more
Handbook of COVID-19 Prevention and Treatment, expecting to share their invaluable practical advice and references with medical staff around the world. This handbook compared and analyzed the experience of other experts in China, and provides good reference to key departments such as hospital infect ... more
The animal health subsector within the agriculture sector is the gatekeeper of antimicrobial resistance (AMR) in livestock, aquaculture, animal products, and the immediate animal environment. In support of member countries taking responsibility for and moving forward with putting AMR monitoring and ... more
Molecular methods for antimicrobial resistance (AMR)diagnostics to enhance the Global Antimicrobial Resistance Surveillance System
User GuideThe toolkit is composed of three sections: Hospital and Health System Resources - includes a readiness assessment tool, the starting point in developing or enhancing a successful Antimicrobial Stewardship Program (ASP). The tool, a checklist developed by the CDC, should be shared with se ... more
The Ghanaian Cabinet approved the antimicrobial resistance (AMR)Policy and Implementation plan(hereafter referred to as the national action plan or NAP)in December 2017, whilst the country case study was in progress. This has set in motion the implementation phase for Ghana, which is a long awaited ... more
Le présent document de travail a été conçu pour offrir des conseils pratiqueset des suggestions sur la manièred’établir et de maintenir la collaboration multisectorielle nécessaire pour élaborer et mettre en œuvre les plans d’action nationaux (PAN) de lutte contre la RAM. Il s’adresse ... more
This working paper was conceived to offer practical tips and suggestions on how to establish and sustain the multisectoral coordination needed to develop and implement National Action Plans on AMR (NAPs). It is intended for anyone with responsibility for addressing AMR at country level. Drawing on b ... more
This paper was developed to support AMR coordination committees and others tasked with addressing AMR at country level to do just that. Drawing on the published literature and the operational experience and expertise of different LMICs, the paper points to six key strategies for success and offers a ... more
Intensive Care Med (2009) 35:9–29DOI 10.1007/s00134-008-1336-9 Although thousands of papers have been devoted tohospital-acquired pneumonia (HAP), many controversiesremain, and management of HAP is probably often sub-optimal. Several reviews or guidelines have been pub-lished rec ... more
The guidelines are to be used to guide the management of adults with lower respiratory tract infection (LRTI). As will be seen in the following text, this diagnosis, and the other clinical syndromes within this grouping, can be difficult to make accurately. In the absence of agreed definitions of th ... more
This interim guidance has been updated with advice on safe and appropriate home care for patients with coronavirus disease 2019 (COVID-19) and on the public health measures related to the management of their contacts.
While infections that develop during hospitalization may appear to be an uncommon but recognized risk of hospital care today, the incidence of these infections has been increasing dramatically during the last 2 to 3 decades, and the risk of acquiring an organism that is resistant to 1 or more antibi ... more
The infectious disease burden in India is among the highest in the world. A large amount of antibiot-ics are consumed in fighting infections, some of them saving lives, but every use adding to antibiotic resistance in bacteria. Antibiotic use is increasing steadily (table 1), particularly ... more
Internationally, there is a growing concern over antimicro-bial resistance (AMR) which is currently estimated to ac-count for more than 700,000 deaths per year worldwide. If no appropriate measures are taken to halt its pro-gress, AMR will cost approximately 10 million lives andabout US$100 trillion ... more
The escalating antimicrobial resistance (AMR) pandemic is a global public health threat with extensive health, economic and societal implications. Resistance emerges because of selection pressure from rational and indiscriminate antimicrobial use in human health as well as in the veterinary, agricul ... more
Overuse of antimicrobial agents occurs globally in both community and hospital settings. Misuse of antibiotics can lead to a variety of adverse outcomes, including the development of antimicrobial resistanceand increased cost of hospitalization. This issuehas been particularly problematic in de ... more
WHO would like to express its gratitude and appreciation to all Member States that provided information to the WHO survey on policies and activities at the national level in the area of antimicrobial resistance. The contribution of staff in WHO Regional and Country Offices has been invaluable: in ga ... more
El abuso y el uso indebido de los antibióticos en animales y humanos están contribuyendo al aumento de la resistencia a estos fármacos. Algunos tipos de bacterias causantes de infecciones humanas graves ya son resistentes a la mayoría o a la totalidad de los tratamientos ... more
Antibiotic stewardship refers to coordinated efforts and activities that seek to measure and improve use of antibiotics. Implementation of ASPs has demonstrated positive public health and clinical impacts including reducing costs, lengths of hospital stays, and the burden of antibiotic resistance wh ... more