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The cardiovascular disease continuum begins with risk factors such as diabetes mellitus (DM), progresses to vasculopathy and myocardial dysfunction, and finally ends with cardiovascular death. Diabetes is associated with a 2- to 4-fold increased risk for heart failure (HF). Moreover, HF patients wit
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h DM have a worse prognosis than those without DM. Diabetes can cause myocardial ischemia via micro- and macrovasculopathy and can directly exert deleterious effects on the myocardium. Hyperglycemia, hyperinsulinemia, and insulin resistance can cause alterations in vascular homeostasis. Then, reduced nitric oxide and increased reactive oxygen species levels favor inflammation leading to atherothrombotic progression and myocardial dysfunction. The classification, diagnosis, and treatment of HF for a patient with and without DM remain the same. Until now, drugs targeting neurohumoral and metabolic pathways improved mortality and morbidity in HF with reduced ejection fraction (HFrEF). Therefore, all HFrEF patients should receive guideline-directed medical therapy. By contrast, drugs modulating neurohumoral activity did not improve survival in HF with preserved ejection fraction (HFpEF) patients. Trials investigating whether sodium-glucose cotransporter-2 inhibitors are effective in HFpEF are on-going. This review will summarize the epidemiology, pathophysiology, and treatment of HF in diabetes.
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These draft guidelines are designed to encourage humanitarian and development non-governmental organisation (NGO) practitioners to think about the types of scientific information and expertise they may need, how to access and use them, and how to ensure that they are applied in an ethical and accoun
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table manner. The publication addresses the need to defines the problem and the purpose of integrating science with the users of science, issues around access to science and understanding scientific information, how to apply the science and the important of monitoring and evaluation of impact. Case studies include a project from Christian Aid and the Evangelical Association of Malawi which brought together community members from Village Civil Protection Committees with scientists from the Department of Climate Change and Meteorology and District Council staff responsible for water management and disaster risk reduction in order to tackle a problem of flooding
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The guide is designed to help disaster managers in national Governments gain basic knowledge of how to use international tools and services. It aims to support the growing disaster response and disaster response preparedness capabilities that exist at national level across Asia and the Pacific.
... The guide is for national disaster management organizations (NDMOs) and line ministries involved in disaster response and disaster response preparedness. It is also a reference document for representatives of intergovernmental organizations, civilsociety actors and disaster-affected people.
The guide concentrates on key tools and services that can be helpful to disaster managers during the response and response preparedness phases of the disaster programme cycle. more
... The guide is for national disaster management organizations (NDMOs) and line ministries involved in disaster response and disaster response preparedness. It is also a reference document for representatives of intergovernmental organizations, civilsociety actors and disaster-affected people.
The guide concentrates on key tools and services that can be helpful to disaster managers during the response and response preparedness phases of the disaster programme cycle. more
The second edition of the WHPCA Global Atlas of Palliative Care was launched during World Hospice & Palliative Care Day 10 October. The Atlas is an update of the original WHPCA/WHO Global Atlas of Palliative care at the end of life published in 2014. It is full of useful facts and figures to support
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palliative care advocacy and development. In this edition we have switched from using the WHO methodology for need for palliative care to the evolving Lancet Commission on Palliative Care and Pain Relief methodology. As a result the number of people needing palliative care has gone from 40 million per year to almost 57 million and more accurately reflects the need for palliative care globally models of palliative care worldwide? What resources are devoted to palliative care? What is the way forward?
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The Antimicrobial Resistance Benchmark has evaluated for the second time how the most important players in the antibiotic market are addressing the rise of resistance and the global need for appropriate access to antibiotics. Although we can see progress — it’s hanging by a thread.
We have reac
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hed a tipping point where large and prominent drugmakers have retreated from the antibiotics field and smaller innovative biotech companies have gone bankrupt due to the poor financial rewards on offer.
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Trachoma causes more vision loss and blindness than any other infection in the world. This disease is caused by Chlamydia trachomatis bacteria. Other variants or strains of these bacteria can cause a sexually transmitted infection (chlamydia) and disease in lymph nodes.
This is photomicrograph
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of a conjunctival smear that revealed the presence of what are known as, intracytoplasmic inclusions Trachoma is easily spread through direct personal contact such as from fingers, through shared towels and clothes, and through flies that have been in contact with the eyes or nose of an infected person. When left untreated, repeated Chlamydia trachomatis infections in the eye can cause severe scarring on the inside of the eyelid. This can cause the eyelashes to scratch the cornea (trichiasis). In addition to causing pain, trichiasis permanently damages the cornea and can lead to irreversible blindness.
Chlamydia trachomatis infections spread in areas that lack access to safely managed drinking water and sanitation systems. Trachoma affects the most resource-limited communities in the world. Globally, almost 1.9 million people have vision loss because of trachoma, and it causes 1.4% of all blindness worldwide.1 In 2021, 136 million people lived in trachoma-endemic areas and were at risk of trachoma blindness.
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Applying the evidence of what works from HIV-related stigma and discrimination in six settings to the COVID-19 response
This brief provide evidence-informed guidance to countries on the intersection of stigma related to HIV and COVID-19 in national
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responses.
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Myanmar continues to experience a severe - and worsening - humanitarian and human rights crisis. Conflict and violence have escalated across the country, impacting children and their families and displacing more than 1.5 million people. Access of conflict-affected populations to services and deliver
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y of humanitarian assistance has been further constrained by restrictions imposed on movement of both people and goods.
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Little is known about foreign aid provided by private donors. This paper contributes to closing this research gap by comparing the allocation of private humanitarian aid to that of official humanitarian aid awarded to 140 recipient countries over the 2000-2016 period. We construct a new database tha
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t offers information on the country in which the headquarters of private donors are located to test whether private donors follow the aid allocation pattern of their home country. Our empirical results confirm that private aid “follows the flag.” This finding is robust against the inclusion of various fixed effects, estimating instrumental variables models, and disaggregating private aid into corporate aid and NGO aid. Donor country-specific estimations reveal that private aid from China, Sweden, the United Kingdom, and the United States “follow the flag.”
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How the Greek reception system is failing to protect the most vulnerable people seeking asylum.
Greece and its EU partners are failing pregnant women, unaccompanied children, victims of torture or sexual violence and other vulnerable people who seek protection in Europe. These people are being put
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at risk by flawed processes and chronic understaffing in EU ‘hotspot’ camps on the Greek islands. They do not receive adequate support from the authorities that are legally responsible for protecting them and are being abandoned in overcrowded camps in squalid conditions. Many people live in unheated tents and do not have sufficient access to washing facilities and toilets, and winter is only making their situation worse
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Burkina Faso remains one of the poorest countries in the world, with 44.5% of the population living below the poverty line. To promote the rights of persons with disabilities, the country has adopted almost all of the relevant initiatives and international legal texts
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on the rights of persons with disabilities including the Convention on the Rights of Persons with Disabilities (CRPD) that was ratified in 2009. The country has also adopted a National Strategy for the Protection and Promotion of Persons with Disabilities (SN-3PH, 2012), based on, amongst other approaches, Community Based Rehabilitation (CBR), promoted by the WHO and LIGHT FOR THE WORLD. Following on from the 2011-2015 country strategy that enabled LIGHT FOR THE WORLD to contribute strongly to the national dialogue on disability, the present strategy 2016-2020 aims to strengthen our achievements in order to work towards an inclusive society in which persons with disabilities fully enjoy their rights.
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Between 1992 and 2012, disasters caused more than 1.3 million deaths, affected more than 4.4 billion people and led to US$ 2 trillion in economic damages and losses around the world. This Disaster Risk Management Strategy explains how the Agency for Technical Cooperation and Development (ACTED) anti
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cipates disasters and advocates for more upstream consideration of their occurrence. There are sections on community based disaster risk management and ecosystem based disaster resilience, as well as a look to the future
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The report provides an overview of the disaster risk reduction and management in Nepal, a country under threat of multiple natural hazards: earthquakes, floods, landslides, fires, storms, the epidemics, and others. It presents background information on
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the country, its disaster profile, its legal and institutional framework, the country's achievements in regards to the Hyogo Framework for Action, and looks at the challenges and future steps in the area of disaster management in Nepal.
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Version 10.1_5 October 2020
These Guidelines are available in different formats: As a paper booklet, a PDF, a mobile app, and now also as a website.
The 2019 version of the Guidelines introduces a new drug-drug interaction panel and now consists of six main sections, including a general overview
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table of all major issues in PLWH, recommendations on antiretroviral treatment, drug-drug interactions, diagnosis, monitoring and treatment of co-morbidities, co-infections and opportunistic diseases.
Available in English, French, Spanish, German, Portuguese, Russian, Chinese and Japanese
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Epidemiologisches Bulletin ; 12. Dezember 2016 / Nr. 49 aktuelle daten und informationen zu infektionskrankheiten und public health
This publication explores how housing, land and property rights issues have been addressed in peace agreements concluded over the past three decades. It provides practical guidance for peace negotiators on all sides in Myanmar and outlines how addre
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ssing these rights in the peace process will build the groundwork needed for an eventual peace agreement or agreements in the country.
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An 82 percent funding gap is putting the lives of 2.5 million people in north-west Syria at risk this winter.
The first cholera case in north-west Syria was confirmed on 19 September. See below for the latest updates.
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On 17 September, at least six airstrikes were reported in Idleb, 10 km away from the road used by the 7th cross-line convoy. One man was injured.
On 27 September, an airstrike reportedly hit in the vicinity of five IDP camps in Idleb, near the Bab AlHawa border crossing, injuring a woman, child and seven men.
HNAP recorded 19,545 new internal displacements in north-west Syria in September – the highest record so far in 2022 - largely driven by the deteriorating economy.
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This document provides a systematic approach in developing a coordinated, standardized, reliable, efficient, cost-effective, and sustainable specimen transport and referral system to support IVHD and VL testing networks. This document provides technical and programmatic recommendations
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on the appropriate specimen storage and transportation of specimens for HIV VL and IVHD testing. Along with the national guidelines for specimen storage and transport, these standards should provide guidance on the creation or improvement of specimen referral networks and specimen transport systems. In addition, standard operating procedures (SOPs) targeting drivers and persons responsible for packing of specimens and results return are included in this document.
No publication year indicated in the document. more
No publication year indicated in the document. more
Democratic dispensation in 1994 created a political and social platform that reshaped life in South Africa. There was a surge in common belief that the inequity and wrong of Apartheid should and could be rectified. Equity of access to water and sanitation were obvious targets for improvement. In 199
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4, an estimated 14–15 million South Africans were without access to an improved water supply, while close to 21 million - more than half of the population at that time - did not have access to improved sanitation facilities. These problems were most severe in poorer rural areas. The water and sanitation sector became unified by the vision of universal access for all South Africans. This case study documents the progression of the sector between 1994 and 2016, and analyzes the impact of local systems created in South Africa to respond to the water and sanitation challenge.
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Guidelines for Good Clinical Laboratory Practices (GCLP) outlines the principles and procedures to be followed by medical laboratories involved in clinical research and/or patient care so as to provide quality data which can be used for health resea
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rch and patient treatment. As the use of laboratory tests (often expensive) are increasingly becoming a part of medical diagnosis and research, generation of quality data would be a cost-effective and ethically sound strategy.
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