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Impact of a Family Clinic Day intervention on paediatric and adolescent appointment adherence and retention in antiretroviral therapy: A cluster randomized controlled trial in Uganda

J. C. Graves; Peter Elyanu; C. J. Schellack; et al. PLOS One (2018) CC
PLOS ONE | https://doi.org/10.1371/journal.pone.0192068 March 9, 2018
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Nothing About Us Without RIGHTS—Meaningful Engagement of Children and Youth: From Research Prioritization to Clinical Trials, Implementation Science, and Policy

C. Oliveras; L. Cluver; S. Bernays; A. Armstrong JAIDS Journal of Acquired Immune Deficiency Syndromes; PubMed (2018) C2
Supplement Article J Acquir Immune Defic Syndr  Volume 78, Supplement 1, August 15, 2018 www.jaids.com
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mHealth intervention “ImTeCHO” to improve delivery of maternal, neonatal, and child care services—A cluster-randomized trial in tribal areas of Gujarat, India

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Community health worker support to improve HIV treatment outcomes for older children and adolescents in Zimbabwe: a process evaluation of the ZENITH trial

C. D. Chikwari; V. Simms; Joanna Busza; et al. Implementation Science; BMC (2018) CC
Dziva Chikwari et al. Implementation Science (2018) 13:70 https://doi.org/10.1186/s13012-018-0762-5
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Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia

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Anti-interleukin-6 therapies for hospitalized patients with COVID-19: a protocol for a prospective meta-analysis of randomized trials

World Health Organization WHO (2021) C_WHO
19 February 2021 The overall objective of this prospective meta-analyses (PMA) is to estimate the effect of anti-IL-6 therapy compared with usual care in hospitalized patients with suspected or confirmed COVID-19. The primary comparison is of the class effect of anti-IL-6 therapies. It will also es... more
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Reducing surgical site infections in low-income and middle-income countries (FALCON): a pragmatic, multicentre, stratified, randomised controlled trial

Biccard, B.M.; V. Msosa, A.L Samateh et al. TheLancet (2021) CC
Surgical site infection (SSI) is the most common postoperative complication worldwide. WHO guidelines to prevent SSI recommend alcoholic chlorhexidine skin preparation and fascial closure using triclosan-coated sutures, but called for assessment of both interventions in low-resource settings. This s... more
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Mobile Tuberculosis Treatment Support Tools to Increase Treatment Success in Patients with Tuberculosis in Argentina: Protocol for a Randomized Controlled Trial

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Routine sterile glove and instrument change at the time of abdominal wound closure to prevent surgical site infection (ChEETAh): a pragmatic, cluster-randomised trial in seven low-income and middle-in

NIHR Global Reserach Health Unit on Global Surgery (2022) CC
The Lancet Vol.400 (2022) p.17-67-1776. Published:October 31, 2022DOI:https://doi.org/10.1016/S0140-6736(22)01884-0. Surgical site infection (SSI) is the most common complication of surgery around the world: ChEETAh trial finds routinely changing gloves and instruments for wound closure could preve... more
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Efficacy and Safety of Pafuramidine versus Pentamidine Maleate for Treatment of First Stage Sleeping Sickness in a Randomized, Comparator-Controlled, International Phase 3 Clinical Trial

Pohlig G, Bernhard SC, Blum J, Burri C, Mpanya A, et al. PLOS Neclected Tropical Diseases (2016) CC
This was a Phase 3, multi-center, randomized, open-label, parallel-group, active control study where 273 male and female patients with first stage Trypanosoma brucei gambiense HAT were treated at six sites: one trypanosomiasis reference center in Angola, one hospital in South Sudan, and four hospita... more
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Assessing the feasibility of interrupting the transmission of soil-transmitted helminths through mass drug administration: The DeWorm3 cluster randomized trial protocol

Ásbjörnsdóttir K.H., Ajjampur S.S.R., Anderson R.M. et al (2018) C2
Soil-transmitted helminths (STH) affect 1.45 billion people worldwide, and high intensity infections are associated with anemia, undernutrition and impaired cognition, particularly among children. Mathematical models suggest it may be possible to interrupt the transmission of STH in a community by e... more
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A household-based community health worker programme for non-communicable disease, malnutrition, tuberculosis, HIV and maternal health: a stepped-wedge cluster randomised controlled trial in Neno Distr

Wroe, E.B.; Nhlema, B.; Dunbar, E.L. et al. BMJ Global Health (2021) CC
Background: Community health worker (CHW) programmes are a valuable component of primary care in resource-poor settings. The evidence supporting their effectiveness generally shows improvements in disease-specific outcomes relative to the absence of a CHW programme. In this study, we evaluated expan... more
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Effect of a single inactivated poliovirus vaccine dose on intestinal immunity against poliovirus in children previously given oral vaccine: an open-label, randomised controlled trial

Jacob John, et al. The Lancet (2014)
The Lancet, Early Online Publication, 11 July 2014 doi:10.1016/S0140-6736(14)60934-X *Free registration is required to view this article
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Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: final results from the Guinea ring vaccination, open-label, cluster-randomised trial (Ebola Ça Suffit!)

Henao-Restrepo, A.M.; et al. (2016)
The Lancet. Published Online December 22, 2016 http://dx.doi.org/10.1016/S0140-6736(16)32621-6. Open Access
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Weekends-off efavirenz-based antiretroviral therapy in HIV-infected children, adolescents and young adults (BREATHER): Extended follow-up results of a randomised, open-label, non-inferiority trial

A. Turkova; C. L. Moore; K. Butler; et al. PLOS One; Pub Med (2018) CC
PLOS ONE | https://doi.org/10.1371/journal.pone.0196239 April 23, 2018
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Interkulturelles Dolmetschen vor Ort – Leitfaden

TRIALOG: Lernplattform zum interkulturellen Dolmetschen (2015) C1
Worauf muss eine Fachperson in der Zusammenarbeit mit einer oder einem professionellen interkulturell Dolmetschenden achten?
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Global roadmap for research and development of tuberculosis vaccines

European & Developing Countries Clinical Trials Partnership EDCTTP; Amterdam Institute for Global health & Development aighd (2021) C1
The roadmap describes the actions needed to achieve the three development goals for TB vaccines set by the WHO: 1. A safe, effective and affordable TB vaccine for adolescents and adults. 2. An affordable TB vaccine for neonates and infants with improved safety and efficacy. 3. A therapeutic v... more
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Shorter treatment for children with minimal TB

SHINE Medical Research Council Clinical Trials Unit (MRC CTU) at UCL (2022) CC
The results of the SHINE trial have been published in the NEJM today. SHINE looked at whether treatment for children with minimal TB could be reduced from 6 months to 4 months. It found that the four month treatment was as good as the standard six months treatment for children with minimal TB
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Answers to common questions about the Ebola prevention marklate study.

Ministry of Health & Sanitation, Sierra Leone (2015)
Sierra Leone Trial to Introduce a Vaccine against Ebola (STRIVE)
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Effectiveness and cost-effectiveness of group support psychotherapy delivered by trained lay health workers for depression treatment among people with HIV in Uganda

Nakimuli-Mpungu, E.; S. Musisi, K. Wamala, et al. (2020) CC
: a cluster-randomised trial. Lancet Glob Health 2020; 8: e387–98