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Recency assays use one or more biomarkers to identify whether HIV infection in a person is recent (usually within a year or less) or longstanding. Recency assays have been used to estimate incidence in representative cross-sectional surveys and in epidemiological studies to better understand the pat ... more
Revised and expanded version of the Guidelines
Rabies is a fatal viral disease, but is preventable in humans. The rabies virus is transmitted to humans through virus-laden saliva from a rabid animal, mostly dogs. The virus is shed in the saliva of an infected animal and can be introduced into another body through bites, scratches and any other ... more
Due to high routine vaccination coverage, overall counts of diphtheria case have significantly declined in the Western Pacific Region recently. However, diphtheria is still prevalent in several countries and areas of the Region and remains a public health issue due to its high case fatality rate. ... more
CEPI is seeking to raise $3.5 billion to implement CEPI’s next 5-year plan. To mitigate the immediate threat of COVID-19 variants, it is activating key elements of this plan now—and seeking to mobilise a portion of this $3.5 billion in 2021. We have already launched R&D programmes to initiate de ... more
The Democratic Republic of Timor-Leste has the highest TB incidence rate in the South East Asian Region - 498 per 100,000, which is the seventh highest in the world. In Timor-Leste TB is the eighth most common cause of death. The salient observations are as follows: In 2018, 487 (12.5%) of the ... more
This publication aims to provide updated guidance on the specific use of yellow fever laboratory assays in the context of surveillance to be used across the Global Yellow Fever Laboratory Network for disease surveillance. In the recent years, new commercial assays became available and are now recomm ... more
Antimicrobials are medicines, including antibiotics, antivirals, antifungals, and antiparasitics, that are used to prevent and treat infections in humans, animals, and plants. Antimicrobial Resistance (AMR) arises when bacteria, viruses, fungi, and parasites no longer respond to these medicines, ren ... more

Revised National Guidelines on Mpox

Wasif Malik, M.; et al. National Institute of Health, Pakistan (2024) CC
This document serves to provide interim guidance/ recommendations to carry out mpox surveillance activities mainly case investigation, contact tracing and isolation. For the development of this document WHO, UKHSA and CDC guidelines were referred to and adopted within the country context.
Quick reference guide
This Clinic Supervisor’s Manual is helpful for focusing managers on the key elements of integrated primary health care as they simultaneously integrate new interventions for HIV/AIDS, tuberculosis, and malaria. This tool contains 12 sections. Section 1 explains how to use the manual. Section 2 hel ... more
Accessed November 2014
PLoS One. 2012; 7(4): e29656. Published online 2012 Apr 20. doi: 10.1371/journal.pone.0029656
The Lancet Global Health 2016 Published Online August 30, 2016 http://dx.doi.org/10.1016/S2214-109X(16)30175-9
This manual describes some of the strategic, managerial, financial, technical and scientific aspects to be considered in establishing a national EQA programme for clinical laboratories and other testing services at all health care levels
Final Report
Accessed Oktober 18, 2017
WHO/CDS/CSR/EDC/99.2 Plague Manual Epidemiology, Distribution, Surveillance and Control
PLOS ONE 10(12): e0144040. doi:10.1371/journal.pone.0144040

Controlled clinical trails in Tuberculosis

A. Jindani, A. Nunn, D. A. Enarson International Union Against Tuberculosis and Lung Disease (2004)
A Guide For Multicentre Trials in High-Burden Countries
DHS Working Papers No. 85
Detection, confirmation and management Salmonella Typhi outbreak
2nd Generation HIV Surveillance in Pakistan, Round 5
This job aid provides information for laboratorians about how to receive, process, and store dried blood spot specimens collected for early infant diagnosis, viral load, or drug resistance testing.
Following the encouraging initial results of the pilot project, the Ministry of Health is committed to increasing access to MDR-TB diagnosis, treatment and care. An expansion plan for the programmatic management of drug-resistant TB has been developed and forms part of the Five Year National Strateg ... more
This document contains: The systematic reviews and GRADE assessments used at the Index-TB Guideline Panel in July 2015; The Evidence to Decision tables that record the Panel’s assessment and recommendations from this meeting
Final Report
HIV drug resistance , Users Manual December 2017
PQDx 0197-045-00 WHO PQDx PR March /2016, version 2.0
PQDx 0006-005-00 WHO PQDx PR February/2016, version 2.0
PQDx 0018-010-00 WHO PQDx PR July/2016, version 3.0
PQDx 0198-071-00 WHO PQDx PR April/2016, version 2.0
PQDx 0181-031-00 WHO PQ Public Report March/2017, version 3.0
30 April 2020 | COVID-19: Essential health services
Molecular methods for antimicrobial resistance (AMR)diagnostics to enhance the Global Antimicrobial Resistance Surveillance System
On the 31st December 2019, the World Health Organization (WHO) China country office reported a cluster of pneumonia cases in Wuhan City, Hubei Province of China now known to be caused by a novel virus. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been confirmed as the causative v ... more
Временное руководство 19 марта 2020 г. Данный документ предоставляет временное руководство лабораториям и заинтересованным сторонам, участвующим в лабораторном ... more
This study addresses part of the Terms of Reference for a scoping report ‘An analysis of approaches to laboratory capacity strengthening for drug resistant infections in low and middle income countries’. It has been produced as a separate report because it is also very relevant for a second stud ... more
Qualitative assay for use on the cobas®6800/8800 Systems. For in vitro diagnostic use
Covid19 - Standard Operating Procedures – UNHAS ROSS This SOP defines WFP Aviation/UNHAS procedures to be followed when operating in areas affected by the current outbreak of the coronavirus disease (COVID-19). This SOP will be communicated to UNHAS staff, Operators, and user organisations. Acco ... more
Accessed: 02.05.2020 These interim IPC recommendations for health settings have been developed through the contributions of many individuals and institutions, such as the Centers for Disease Control-Kenya; ITECH; US Agency for International Development (USAID) Medicines, Technologies, and Pharmaceu ... more
Short Version This clinical practice guideline was developed in order to provide recommendations for the management of critically ill adult patients with COVID-19 in intensive care units (ICUs).
Weekly epidemiological update on COVID-19, 28 September 2022
COVID-19 outbreak is associated with the generation of many types of infectious wastes, including infected masks, gloves and other protective equipment, together with a higher volume of general waste of the same nature.
The overall goal of surveillance, case investigation and contact tracing in this context is to stop human-to-human transmission to control the outbreak. The key objectives of surveillance and case investigation are to rapidly identify cases and clusters in order to provide optimal clinical care; to ... more
Here you can find the latest reports
Leptospirosis is a zoonotic disease with epidemic potential, especially after a heavy rainfall, caused by a bacterium called Leptospira. Leptospira interrogans is pathogenic to humans and animals, with more than 200 serologic variants or serovars. Humans usually acquire leptospirosis through dire ... more
BMJ Open 2021;11:e042279. doi:10.1136/bmjopen-2020-042279. Neglected tropical diseases tend to cluster in the same poor populations, and to make progress with their control, they will have to be dealt with in an integrated manner. Peptide microarrays may be a solution to tese problems, where diagnos ... more
Diagnosis, Case Management Prevention and Control of Leptospirosis
i. A person who is a contact of a probable or confirmed mpox case in the 21 days before the onset of signs or symptoms, and who presents with any of the following: acute onset of fever (>38.5°C), headache, myalgia (muscle pain/body aches), back pain, profound weakness or fatigue. OR ii. A per ... more
Developing protocols for use with refugees and internally displaced persons

District Laboratory Practice in Tropical Countries Part-2

Cheesbrough, M. Cambridge University Press (2006) C4
These guidelines are designed for settings with limited resources to provide inexpensive and effective control strategies for prevention of TB transmission in health care workers (HCW).
The government of Rwanda conducted the 2010 Rwanda Demographic and Health Survey (RDHS) to gather up-to-date information for monitoring progress on healthcare programs and policies in Rwanda, including the Economic Development and Poverty Reduction Strategy (EDPRS), the Millennium Development Goals ... more

Laboratory diagnosis of Buruli ulcer

Portaels, F- World Health Organization WHO (2014) C_WHO
A manual for health care providers. This manual provides expert guidance on the laboratory techniques and procedures used in the diagnosis of Buruli ulcer, a disease caused by Mycobacterium ulcerans. Aimed at laboratory technicians and scientists working on this disease, the manual details the exac ... more
3rd edition
The new WHO guidelines provide recommended steps for safe phlebotomy and reiterate accepted principles for drawing, collecting blood and transporting blood to laboratories/blood banks.
Ebola Virus Disease Outbreak Response Plan in West Africa July to December 2014. Annex 1
Morbidity and Mortality Weekly Report (MMWR):
Guide to monitoring and evaluating