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There is no secret to our procedure: the daily scanning of the literature helps us to stay afloat in the never-ending waves of new publications about SARS-CoV-2 and COVID-19. Many papers discussed in the Top 10 will eventually make it into subsequent editions of COVID Reference.
Environmental Research Volume 151, November 2016, Pages 115-123 Dengue is the world’s most important arboviral disease in terms of number of people affected. Over the past 50 years, incidence increased 30-fold: there were approximately 390 million infections in 2010. Globalization, trade, travel, ... more
Climate change is already having severe impacts across our planet, bringing new and previously unimaginable challenges to the people least responsible for greenhouse gas emissions. This report, the first we’ve released jointly in the history of our organizations, provides a sobering review of h ... more

Tuberculosis control in prisons (Russian edition)

A. Bone; A. Aerts, M. Grzemska World Health Organization; International commitee of the Red Cross (2002) C_WHO
A manual for programme managers.
This evaluation is the fifth in a series of structured evaluations of CFS and was completed as part of three-year collaboration with World Vision and Columbia University. It was conducted with Syrian refugees in an urban setting in Zarqa, Jordan during the months of February to August 2014. The CFS ... more
orientations provisoires, première publication : 8 janvier 2021, mise à jour : 15 juin 2021, mise à jour : 19 novembre 2021, mise à jour : 21 janvier 2022
orientations provisoires, première publication le 25 janvier 2021, mise à jour le 15 juin 2021, mise à jour le 19 novembre 2021
Настоящее руководство «Клиническое ведение случаев COVID-19» базируется на вышеуказанных стратегических приоритетах и адресовано клиницистам, участвующим в оказа ... more
Guidelines for treatment of drug-susceptible tuberculosisand patient care 2017 Update
Q8.SCOPING QUESTION: In adults and older adolescents with depressive disorder, what is the comparative effectiveness of different formats of psychological treatments?
Guidelines for the care and treatment of persons diagnosed with chronic hepatitis C virus infection
Se sabe que las mujeres embarazadas experimentan cambios inmunológicos y fisiológicos que pueden hacerlas más susceptibles a las infecciones respiratorias virales, incluido COVID-19. Varios estudios revelaron que las mujeres embarazadas con diferentes enfermedades resp ... more
orientaciones provisionales, 23 de abril de 2020
As of 15 May 2020, more than 4 million confirmed cases of COVID-19, including more than 285,000 deaths have been reported to WHO. The risk of severe disease and death has been highest in older people and in persons with underlying noncommunicable diseases (NCDs), such as hypertension, cardiac diseas ... more
Improvements in water sanitation and hygiene (WASH) and wastewater management in all sectors are critical elements of preventing infections and reducing the spread of antimicrobial resistance (AMR) as identified in the Global Action Plan to combat AMR. Yet, at present, WASH and wastewater management ... more
Nota INformatIva Nº 13/2020 - SE/GaB/SE/mS September 2020
Resumen ejecutivo guía de práctica clínica manejo de la infección por Sars-CoV 2
Phil. Trans. R. Soc. B (2010) 365, 2959–2971; doi:10.1098/rstb.2010.0143. Agricultural ecosystems provide humans with food, forage, bioenergy and pharmaceuticals and are essential to human wellbeing. These systems rely on ecosystem services provided by natural ecosystems, including pollination, b ... more
Este documento ha sido revisado y aprobado por la Ponencia de Alertas y Planes de Preparación y Respuesta. Este protocolo está en revisión permanente en función de la evolución y nueva información que se disponga de la infección por el nuevo coronavirus (SARS-CoV-2 ) .
Stenotrophomonas maltophiliais a nonfermenting Gram-negative rod that is ubiquitous in nature (predominantly occurring in aquatic environments and on plants). Biochemically, it iscatalase positive and oxidase negative, and it produces acid frommaltose (hence the name“maltophilia”). Due to it ... more
Доклад на тему злоупотребление алкоголем в Российской Федерации: социально-экономические последствия и меры противодействия, который был утвержден Советом Общес ... more
International Journal of Science Annals DOI 10.26697/ijsa.2018.1-2.05; UDC 159.9.072(477)
Il nuovo mini-textbook Nei prossimi mesi, COVID Reference presenterà aggiornamenti regolari e racconterà i dati scientifici nel modo più completo possibile.
This chapter addresses the biogeochemical cycles of carbon dioxide. (CO2), methane (CH4) and nitrous oxide (N2O)
Mais pessoas morrem a cada ano de doenças cardiovasculares do que de qualquer outra causa. Mais de três quartos das mortes por doenças cardíacas e acidentes vasculares cerebrais ocorrem em países de baixa e média renda. A hipertensão - ou pressão alta - é uma condição médica grave que au ... more
The guide to implementing the One Health Joint Plan of Action (OH JPA) at national level provides practical guidance on how countries can adopt and adapt the OH JPA to strengthen and support national One Health action. Building on the OH JPA theory of change, this guide describes three pathways a ... more
There is no secret to our procedure: the daily scanning of the literature helps us to stay afloat in the never-ending waves of new publications about SARS-CoV-2 and COVID-19. Many papers discussed in the Top 10 will eventually make it into subsequent editions of COVID Reference.
La evolución de los acontecimientos y el esfuerzo conjunto de la comunidad científica mundial, hangeneradogran cantidad de información que se modificarápidamente con nuevas evidencias. Este documento pretende hacer unresumen analítico de la evidencia científica dispo ... more
The goal of this Global Action Plan is to articulate synergistic actions that will be required to prevent HIVDR from undermining efforts to achieve global targets on health and HIV, and to provide the most effective treatment to all people living with HIV including adults, key populations, pregnant ... more
ДОПОЛНЕНИЕ СЛУГИ ТЕСТИРОВАНИЯ НА ВИЧ ДЕКАБРЬ 2016 г.
РУКОВОДСТВО ПО ДОПОЛНЕНИЕ К СВОДНОМУ РУКОВОДСТВУ ПО УСЛУГАМ ТЕСТИРОВАНИЯ НА ВИЧ ДЕКАБРЬ 2016 г. УСЛУГИ ТЕСТИРОВАНИЯ НА ВИЧ
La presente publicación describe las medidas de bioseguridad para disminuir el riesgo de infección por COVID-19 durante la atención estomatológica., así como las actividades y procedimientos del personal que brinda atención estomatológica para disminuir el riesgo de infección por COVID-19.
This policy brief aims to provide a review of the current progress on implementing the Burkina Faso national action plan on AMR, identifies critical gaps, and highlights findings to accelerate further progress in the human health sector. The target audience includes all those concerned with implemen ... more
This policy brief aims to provide a review of the current progress on implementing the Kenya national action plan on AMR, identifies critical gaps, and highlights findings to accelerate further progress in the human health sector. The target audience includes all those concerned with implementing ac ... more
The report presents current information (updated to September 2015) on candidate vaccines, therapies and medical devices for Ebola and gives an overview of completed and on-going trials.

El control de la Tuberculosis en prisones

A. Bone; A. Aerts, M. Grzemska Organizaición Mundial de la Salud; Comité internacional de la Cruz roja (2000) C_WHO
Manual para directores de programas
Update 2021; Immunization, Vaccines and Biologicals
Silicosis is not a new disease; the impact of silica dust on respiratory function was observed by Hippocrates in 430 B.C. and in the 16th century by Agricol. In 1713, Rammazini described silicotic nodules in post-mortems of stone cutters presenting with respiratory symptoms. In the mid-late 1800s, ... more
Guidance on Implending Publi-Private Mix Approaches
Guidelines HIV testing services July 2015
Este documento apresenta uma orientação provisória aos laboratórios e diferentes atores envolvidos na realização de exames laboratoriais para o vírus COVID-19. Ele baseia-se parcialmente na orientação provisória para os exames laboratoriais do coronavírus da Síndrome Respiratória do Ori ... more
Child friendly spaces (CFS) are safe spaces where communities create nurturing environments in which children can access free and structured play and learning activities. CFS, also commonly referred to as Child Centred Spaces or Safe Spaces for Children, may provide educational and psychosocial ... more
ESTA NOTA INFORMATIVA SUBSTITUI A NOTA INFORMATIVA Nº 11/2020-SE/GAB/SE/MS, DE 15 DE JUNHO DE 2020, QUE SUBSTITUIU A NOTA INFORMATIVANº 9/2020-SE/GAB/SE/MS, DE 20 DE MAIO DE 2020
Community health nurses have the potential to make significant contributions to meet the health care needs of various population groups in a variety of community settings. In order to assess the extent to which CHNs are achieving this potential, WHO conducted a study between 2010 and 2014 that exami ... more
orientaciones provisionales, 14 de junio de 2021
Uso de doxiciclina para prevenção e tratamento de pacientes com Covid-19
Considerations on the implementation and adjustment of public health and social measures in the context of COVID-19 Interim guidance 14 June 2021
The Quadripartite Organizations – the Food and Agriculture Organization of the United Nations (FAO), the United Nations Environment Programme (UNEP), the World Organisation for Animal Health (WOAH, founded as OIE), and the World Health Organization (WHO) – collaborate to drive the change and tra ... more

One Health Joint Plan of Action (2022-2026)

World Organisation for Animal Health Food and Agriculture Organization of the United Nations; United Nations Enviroment Programme; Wolrd Health Organization; World Organisation for Animal Health (2022) C_WHO
The desired impact of the OH JPA is a world better able to prevent, predict, detect and respond to health threats and improve the health of humans, animals, plants and the environment while contributing to sustainable development. The OH JPA aims to work towards this vision in the following way: ... more
El presente informe incluye análisis de consultas informales en cinco de las regiones de la OMS: la Región de África, la Región de las Américas (donde se realizaron consultas separadas para el Caribe y América del Norte, y para América Latina), la Región de Asia Sudoriental, la Región de Eu ... more
El presente informe incluye análisis de consultas informales en cinco de las regiones de la OMS: la Región de África, la Región de las Américas (donde se realizaron consultas separadas para el Caribe y América del Norte, y para América Latina), la Región de Asia Sudoriental, la Región de Eu ... more
Guidance for clinical case management of thrombosis syndrome with thrombocytopenia (TTS) following vaccination to prevent coronavirus disease (COVID-19) Interim guidance 19 July 2021

WHO Expert Consultation on Rabies. 3rd report

Abela-Ridder, B. World Health Organisation (WHO) (2018) C_WHO
WHO TRS N°1012. Key updates include: (i) surveillance strategies, including cross-sectoral linking of systems and suitable diagnostics; (ii) the latest recommendations on human and animal immunization; (iii) palliative care in lowresource settings; (iv) risk assessment to guide management of bite ... more
10 May 2021 This scientific brief replaces the WHO Scientific Brief entitled “’Immunity passports’ in the context of COVID-19”, published 24 April 2020. This update is focused on what is currently understood about SARS-CoV-2 immunity from natural infection. More information about considera ... more
6 June 2022 These WHO interim recommendations on the use of the Janssen Ad26.COV2.S (COVID-19) vaccine were developed on the basis of advice issued by the Strategic Advisory Group of Experts on Immunization (SAGE) and the evidence summary included in the background document referenced below. Th ... more
Esta orientação provisória foi desenvolvida com base na recomendação emitida pelo Grupo Consultivo Estratégico de Especialistas (SAGE) em imunização, em sua reunião extraordinária de 5 de janeiro de 2021, e atualizada durante sua reunião extraordinária de 27 de maio de 2021 (2), sendo no ... more
21 January 2022 The overall threat posed by Omicron largely depends on four key questions: (i) how transmissible the variant is; (ii) how well vaccines and prior infection protect against infection, transmission, clinical disease and death; (iii) how virulent the variant is compared to other varian ... more
Updated Treatment Guidelines
O SAGE aplica os princípios da medicina baseada em evidências e estabeleceu um processo metodológico completo para emitir ou atualizar recomendações. Especificamente para vacinas contra a COVID-19, uma descrição detalhada dos processos metodológicos pode ser encontrada no esquema de evidênc ... more
SARS-CoV-2 infections among children and adolescents cause less severe illness and fewer deaths compared to adults. While a less severe course of infection is a positive outcome, there are concerns that mild symptoms may have led to less testing, resulting in fewer identified cases of COVID-19 in ch ... more
At present at least 2.2 billion people around the world have a vision impairment, of whom at least 1 billion have a vision impairment that could have been prevented or is yet to be addressed. The world faces considerable challenges in terms of eye care, including inequalities in the coverage and qua ... more
Stand 2.10.2020
The Core Elements of Outpatient Antibiotic Stewardship provides a framework for antibiotic stewardship for outpatient clinicians and facilities that routinely provide antibiotic treatment. This report augments existing guidance for other clinical settings. In 2014 and 2015, respectively, CDC release ... more
Scientific Brief 9 July 2020
4 April 2020 This interim guidance on oxygen sources and distribution strategies for COVID-19 treatment has been adapted from WHO and UNICEF’s technical specifications and guidance for oxygen therapy devices, which is part of the WHO medical device technical series. This guidance is intended for ... more
Severe cases of COVID-19 are associated with rehabilitation needs related to the consequences of ventilatory support, and prolonged immobilization and bed rest. These may include: − Impaired lung function; − Physical deconditioning and muscle weakness; − Delirium and other cognitive impairment ... more
COVID-19 e oxigênio: Os dados da China sugerem que embora a maioria das pessoas com COVID-19 tenham doença leve (40%) ou moderada (40%), cerca de 15% apresentam doença grave que requer oxigenoterapia, e 5% ficam em estado crítico e precisam de tratamento em uma unidade de terapia intensiva. Alé ... more
Updated 10 August 2020 This document presents an essential medicines list (EML) to manage patients in intensive care units (ICUs) with suspected or confirmed COVID-19 diagnosis, which includes active ingredients with dosage form and concentration, and are preferably in the WHO Model Lists of Essent ... more
Consensual Recommendation for treatment of COVID-19 in older adults
Update, 23 de junio de 2022
The objective of this document is to guide the preparation and implementation of national preparedness plans for the safety of substances of human origin during outbreaks of Zika virus infection, both in affected and non-affected areas.
Journal of Infectious Diseases and Therapeutics, 2013, 1, 17-24
Report of the Joint World Health Organization–Brien Holden Vision Institute Global Scientific Meeting on Myopia | University of New South Wales, Sydney, Australia 16–18 March 2015
The Guidelines for the Diagnosis, Treatment and Prevention of Leprosy provide state-of-the-art knowledge and evidence on leprosy diagnosis, treatment and prevention based on a public health approach in endemic countries. The target audience of this document includes policy-makers in leprosy or infec ... more

Policy in action

World Health Organization (Europe) (2017) C_WHO
A tool for measuring alcohol policy implementation
Defending Rights Breaking Barriers Reaching People with HIV Services Global Aids Update 2019

Miles to go

UNAIDS (Joint United Nations Programme on HIVAIDS) UNAIDS (Joint United Nations Programme on HIVAIDS) (2018) C2
Global AIDS Update 2018 Closing Gaps Breaking Barriers Righting injustices
Antimicrobials are widely used in food animal production, and use is rapidly increasing. In an era of growing demand for animal products, there is an increasing trend towards the industrial production of food animals, especially in lower- and middle-income countries (LMICs). One hallmark of this me ... more
Updated Interim guidance 29 July 2020 The provision of safe water, sanitation and waste management and hygienic conditions is essential for preventing and for protecting human health during all infectious disease outbreaks, including of coronavirus disease 2019 (COVID-19). Ensuring evidenced-based ... more
6th edition 13 January 2021 CR 2021.6.10, uploaded on 27 May 2021 Find eight editions: Deutsch | English | Español | Français | Italiano | Português | Tiếng Việt | Türkçe https://covidreference.com/download
4ª edição Nos próximos meses, a COVID Reference apresentará atualizações regulares e narrará os dados científicos o mais coerente possível.
Este documento dá orientações sobre o uso de máscaras na comunidade durante a assistência domiciliar e em serviços de saúde em regiões que têm relatado casos de COVID-19. É dirigido a indivíduos na comunidade, profissionais de saúde pública e de prevenção e controle de infecção (PCI ... more
This document provides guidance on the implementation of the shielding approach in camps and camp-like settings for refugees and internally displaced persons. It is intended for the displaced community itself, humanitarian actors and camp coordination / management authorit ... more
This document updates the earlier version published in April 2020. In recent weeks, information on the potential use of chloroquine or hydroxychloroquine for the treatment of people with COVID-19 has been disseminated in academic journals and public media. Although there are now ongoing clinical tri ... more
Infection preventions Hygiene
Scientific Brief, 17 June 2020
Primary care health centers and providers who care for individuals with hypertension and cardiovascular disease have an important role to play in ensuring continued access to care, reducing the risk of coronavirus infection, and appropriately managing people with these co-morbidities who acquire COV ... more
В настоящем документе представлен первоначальный обзор поступающей информации (по состоянию на 2 июля 2020 г.) о взаимосвязи между COVID-19, НИЗ и факторами риска НИЗ. Ре ... more