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New Therapeutics for Chagas Disease: Charting a Course to Drug Approval

Man, A. & Segal, F. Intechopen (2022) CC
DOI: 10.5772/intechopen.102891Little progress has been made since the 1960s and 19. 70s to widen the therapeutic arsenal against Trypanosoma cruzi, the causative pathogen of Chagas disease, which remains a frustrating and perplexing infectious .... This chapter focuses on the strategic and operational challenges in the clinical drug development of a novel antitrypanosomal agent for Chagas disease. The various elements that contribute to a robust assessment of treatment effect including dose selection, choice of patient population, trial methodology, endpoint measures, and regulatory perspectives are discussed. The learnings herein should serve as resource to help researchers and other stakeholders optimize their clinical development plans and speed delivery of new medicines to patients with Chagas disease. more
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Global leprosy (‎Hansen disease)‎ update, 2023: Elimination of leprosy disease is possible – Time to act!

World Health Organisation (WHO) (2024) C_WHO
English and French
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New generations free of HIV, syphilis, hepatitis B and Chagas disease in the Americas 2018

M. Alonso González; M. B. Mello; L. Sereno; et al. Pan American Health Organization; World Health Organization (Americas); Unicef (2019) C_WHO
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Case definitions, clinical classification, and disease phases

Pan American Health Organization PAHO (2023) C_WHO
The purpose of this document is to present concise information on the current case definitions for dengue, chikungunya, and Zika proposed by PAHO, as well as information on the clinical phases and severity classification of dengue and chikungunya.
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Epidemiología y factores de riesgo

Centers for disease control and prevention CDC (2022) CC
La enfermedad de Chagas, también conocida como tripanosomiasis americana, es causada por el parásito Trypanosoma cruzi. La forma más común de contraer la infección es a través del contacto con las heces de un insecto triatominio (conocido con los nombres de chinche besucona, benchuca, vinchuca... more
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Laboratory diagnosis of Buruli ulcer
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Portaels, F- World Health Organization WHO (2014) C_WHO
A manual for health care providers. This manual provides expert guidance on the laboratory techniques and procedures used in the diagnosis of Buruli ulcer, a disease caused by Mycobacterium ulcerans. Aimed at laboratory technicians and scientists w... more
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Buruli ulcer [comic]
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World Health Organization (WHO) (2011) C_WHO
Buruli ulcer mostly affects children. This comic is aimed at giving them a better knowledge of the disease.
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Prevention of disability in Buruli ulcer-Health Education

World Health Organization WHO (2006) C_WHO
Prevention of disability in Buruli ulcer Learn how to identify and treat the disease early. Learn how to prevent disability.
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Principaux repères Ulcère de Buruli (infection à Mycobacterium ulcerans)

Organisation Mondiale de la Santé OMS (2022) C_WHO
Principaux faits L’ulcère de Buruli est une infection chronique débilitante causée par la bactérie Mycobacterium ulcerans. L’ulcère de Buruli a été signalé dans au moins 33 pays situés dans des régions au climat tropical, s... more
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Nota descriptiva Úlcera de Buruli (infección por Mycobacterium ulcerans)

Organización Mundial de la Salud OMS (2022) C_WHO
Datos y cifras La úlcera de Buruli es una enfermedad crónica y debilitante causada por una micobacteria ambiental: Mycobacterium ulcerans. Al menos 33 países de clima tropical, subtropical o templado han notificado casos de úlcera de... more
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Target product profile for a diagnostic test to confirm visceral leishmaniasis

World Health Organisation (WHO) (2024) C_WHO
In 2007, the Sixtieth World Health Assembly adopted resolution WHA60.13 on control of leishmaniasis, urging Member States, among other actions: to strengthen prevention, active detection and treatment of cases of both cutaneous and visceral leishmaniasis in order to decrease the ... burden; and to strengthen the capacity of peripheral health centres to deliver primary and secondary care, so that they provide appropriate affordable diagnosis and treatment and act as sentinel surveillance sites. more
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Risk communication and community engagement readiness and response toolkit: dengue fever

World Health Organisation (WHO) (2024) C_WHO
This toolkit is a comprehensive set of practical tools and resources designed to support country-level risk communication and community engagement (RCCE) practitioners, decision-makers, and partners to plan and implement readiness and response activities for dengue fever outbreaks. The toolkit conta... more
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Diagnostic de l’ulcère de Buruli au laboratoire
recommended

Portaels, F. Organisation Mondiale de la Santé (2014) C_WHO
Manuel destiné au personnel de santé. Le présent manuel est un guide spécialisé sur les techniques et les méthodes de laboratoire à utiliser pour le diagnostic de l’ulcère de Buruli, une maladie provoquée par Mycobacterium ulcerans. Destiné aux techniciens et aux scientifi ques de labora... more
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L'ulcère de Buruli [bande dessinée]
recommended

Organisation mondiale de la Santé (OMS) (2011) C_WHO
L'ulcère de Buruli touche surtout les enfants. Cette bande dessinée vise à leur donner une meilleure connaissance de la maladie.
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Mapping the global distribution of Buruli ulcer: a systematic review with evidence consensus

Hope Simpson, Kebede Deribe, Earnest Njih Tabah, Adebayo Peters et al. The Lancet Journal (2019) CC
The Lancet Global Health Volume 7, ISSUE 7, e912-e922, July 01, 2019
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First meeting of the network on Buruli ulcer PCR laboratories in the WHO African Region Centre Pasteur du Cameroon, Yaoundé, 21–24 October 2019

World Health Organization WHO (2020) CC
Research to develop point-of-care tests is in progress. Treatment of Buruli ulcer comprises 8 weeks of combined antibiotics (rifampicin and clarithromycin). Complementary therapies such as wound care, skin graft and prevention of disability are needed in some cases to ensure full recovery. The targ... more
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Première réunion du réseau de laboratoires PCR pour l’ulcère de buruli dans la région africaine de l’OMS, Centre Pasteur du Cameroun, Yaoundé, 21–24 octobre 2019

Organisation Mondiale de la Santé OMS (2020) CC
L’ulcère de Buruli, une infection causée par Mycobacterium ulcerans, touche plus de 33 pays dans le monde, mais un peu moins de la moitié seulement de ces pays communiquent régulièrement des données sur la maladie à l’OMS.
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Mandat Réseau de laboratoires et nouveau modèle de programme d’évaluation externe de la qualité des tests de diagnostic par PCR de l’ulcère de Buruli dans la Région africaine de l’OMS

Organisation Mondiale de la Santé OMS (2020) C1
Au total, 18 laboratoires de 13 pays ont participé aux quatre cycles d'AQE : 10 laboratoires de huit pays africains endémiques, dont quatre ont participé aux quatre cycles et trois à trois cycles. Les résultats globaux ont montré que la performance médiane de ces laboratoires s'est amélioré... more
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WHO Meeting on Buruli ulcer and other skin NTDs. Final report.

World Health Organization WHO (2019) C_WHO
The World Health Organization (WHO) convened a meeting of the Technical Advisory Group on Buruli ulcer at its headquarters in Geneva, Switzerland on 25 to 27 March 2019
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Report of a WHO–FIND meeting on diagnostics for Buruli ulcer

WHO Tecnical Advisory Group and FIND (2018) CC
The meeting was held from 26 to 27 March 2018 to review and discuss the following topics: Advances and challenges in the use of fTLC, and new approaches to detecting mycolactone using monoclonal antibodies (mAbs). The status of development of rapid diagnostic tests (RDTs) targeting the MUL... more