Preventive chemotherapy with praziquantel (PZQ) is the cornerstone of schistosomiasis control. However, a single dose of PZQ (40 mg/kg) does not cure all infections. Repeated doses of PZQ at short intervals might increase efficacy in terms of cure rate (CR) and intensity reduction rate (IRR). Here, ...we determined the efficacy of a single versus four repeated treatments with PZQ on Schistosoma mansoni infection in school-aged children from Côte d'Ivoire, using two different diagnostic tests.
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Website last accessed on 10.04.2023
Soil transmitted helminth (STH) infections are among the most common human infections worldwide with over 1 billion people affected. Many estimates of STH infection are often based on school-aged children (SAC). This study produced predictive risk-maps of STH on a more finite scale, estimated the nu...mber of people infected, and the amount of drug required for preventive chemotherapy (PC) in Ogun state, Nigeria. Georeferenced STH infection data obtained from a cross-sectional survey at 33 locations between July 2016 and November 2018, together with remotely-sensed environmental and socio-economic data were analyzed using Bayesian geostatistical modelling. Stepwise variable selection procedure was employed to select a parsimonious set of predictors to predict risk and spatial distribution of STH infections. The number of persons (pre-school ages children, SAC and adults) infected with STH were estimated, with the amount of tablets needed for preventive chemotherapy. An overall prevalence of 17.2% (95% CI 14.9, 19.5) was recorded for any STH infection. Ascaris lumbricoides infections was the most predominant, with an overall prevalence of 13.6% (95% CI 11.5, 15.7), while Hookworm and Trichuris trichiura had overall prevalence of 4.6% (95% CI 3.3, 5.9) and 1.7% (95% CI 0.9, 2.4), respectively. The model-based prevalence predictions ranged from 5.0 to 23.8% for Ascaris lumbricoides, from 2.0 to 14.5% for hookworms, and from 0.1 to 5.7% for Trichuris trichiura across the implementation units. The predictive maps revealed a spatial pattern of high risk in the central, western and on the border of Republic of Benin. The model identified soil pH, soil moisture and elevation as the main predictors of infection for A. lumbricoides, Hookworms and T. trichiura respectively. About 50% (10/20) of the implementation units require biannual rounds of mass drug administration. Approximately, a total of 1.1 million persons were infected and require 7.8 million doses. However, a sub-total of 375,374 SAC were estimated to be infected, requiring 2.7 million doses. Our predictive risk maps and estimated PC needs provide useful information for the elimination of STH, either for resource acquisition or identifying priority areas for delivery of interventions in Ogun State, Nigeria.
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La schistosomiase est une parasitose aiguë et chronique provoquée par des vers (trématodes) du genre Schistosoma. Au moins 249 millions de personnes ont eu besoin d’un traitement préventif en 2012. Le traitement préventif, qui doit être répété sur plusieurs années, permettra de réduire ...et de prévenir la morbidité.
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Aide-mémoire - Chikungunya
Aide-mémoire - Leishmaniose
Website last accessed on 14.04.2023
Food-borne trematode infections are zoonotic, and their pathogens can be transmitted to humans only after the completion of a complex life cycle, some stages of which take place in the body of an intermediate animal host. The first intermediate hosts of all tr...ematode species are freshwater snails. The second host varies depending on the species: in the case of clonorchiasis and opisthorchiasis it is freshwater fish, and in the case of paragonimiasis it is crustaceans.
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Website last accessed on 14.04.2023
Food-borne trematode infections are zoonotic, and their pathogens can be transmitted to humans only after the completion of a complex life cycle, some stages of which take place in the body of an intermediate animal host. The first intermediate hosts of all tr...ematode species are freshwater snails. The second host varies depending on the species: in the case of clonorchiasis and opisthorchiasis it is freshwater fish, and in the case of paragonimiasis it is crustaceans.
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Website last accessed on 14.04.2023
The GARC Education Platform (GEP) is a set of free online courses developed to improve the skills and knowledge of people working in rabies awareness and prevention. Through the GEP, we aim to empower people to become rabies advocates, focal persons, and exper...ts across the globe. After completing each course, you become a certified graduate and receive a unique certificate of completion!
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oil-transmitted helminth (STH) infections are among the most common infections worldwide and affect the poorest and most deprived communities.
They are transmitted by eggs present in human faeces which in turn contaminate soil in areas where sanitation is poor.
The main species that infect peopl...e are the roundworm (Ascaris lumbricoides), the whipworm (Trichuris trichiura) and the hookworms (Necator americanus and Ancylostoma duodenale).
Intestinal worms produce a wide range of symptoms including intestinal manifestations (diarrhoea, abdominal pain), general malaise and weakness. Hookworms cause chronic intestinal blood loss that result in anaemia.
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Soil-transmitted helminth (STH) infections are among the most common infections worldwide with an estimated 1.5 billion infected people or 24% of the world’s population. These infections affect the poorest and most deprived communities with poor access to clean water, sanitation and hygiene in tro...pical and subtropical areas, with the highest prevalence reported from sub-Saharan Africa, China, South America and Asia. They are transmitted by eggs present in human faeces, which in turn contaminate soil in areas where sanitation is poor. Over 260 million preschool-age children, 654 million school-age children,108 million adolescent girls and 138.8 million pregnant and lactating women live in areas where these parasites are intensively transmitted, and are in need of treatment and preventive interventions.
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Las geohelmintiasis son una de las parasitosis más comunes en el mundo, y se estima que 1500 millones de personas, el 24 % de la población mundial, están infestadas. Estas infestaciones afectan a las comunidades más pobres y desfavorecidas de zonas tropicales y subtropicales con un acceso defici...ente a servicios de agua limpia, saneamiento e higiene, y la prevalencia más alta se ha notificado en el África subsahariana, China, América del Sur y Asia. Las geohelmintiasis transmiten a través de los huevos de los parásitos eliminados con las heces fecales de las personas infestadas, que, a su vez, contaminan el suelo en zonas donde el saneamiento es deficiente. Más de 260 millones de niños en edad preescolar, 654 millones de niños en edad escolar, 108 millones de niñas adolescentes y 138,8 millones de embarazadas y madres lactantes viven en zonas donde la transmisión de esos parásitos es intensa y, por esa razón, necesitan tratamientos e intervenciones preventivas.
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Les géohelminthiases comptent parmi les infections les plus courantes dans le monde, plus de 1,5 milliard de personnes, soit près de 24 % de la population mondiale, étant infestées à l’échelle mondiale. Ces infections touchent les communautés les plus pauvres et les plus défavorisées ayan...t un accès limité à l’eau potable, à l’assainissement et à l’hygiène dans les régions tropicales et subtropicales, la plus forte prévalence étant recensée en Afrique subsaharienne, en Chine, en Amérique du Sud et en Asie. Elles se transmettent par des œufs présents dans les excréments humains, qui contaminent les sols là où les conditions d’assainissement sont insuffisantes. Plus de 260 millions d’enfants d’âge préscolaire, 654 millions d’enfants d’âge scolaire, 108 millions d’adolescentes et 138,8 millions de femmes enceintes ou allaitantes vivent dans des zones où il existe une transmission à grande échelle de ces parasites et nécessitent un traitement et la mise en place de mesures préventives.
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Передающиеся через почву гельминтозы (ППГ) относятся к наиболее распространенным инвазиям во всем мире и, согласно расчетам, поражают 1,5 млрд человек, или 24% мирово...о населения. Они поражают беднейшие и наиболее обездоленные группы населения, не имеющие полноценного доступа к чистому водоснабжению и санитарно-гигиеническим средствам, на территории тропических и субтропических районов и, по имеющимся данным, наиболее распространены в странах Африки к югу от Сахары, Китае, Южной Америке и Азии. Они передаются через яйца, присутствующие в фекалиях человека, которые в неблагополучных с санитарной точки зрения районах попадают в почву. В районах интенсивной передачи данных паразитов проживает более 260 млн детей дошкольного возраста, 654 млн детей школьного возраста, 108 млн девочек-подростков и 138,8 млн беременных и кормящих грудью женщин, все из которых нуждаются в лечении и профилактике.
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عد عدوى الديدان الطفيلية المنقولة بالتربة من بين أكثر أنواع العدوى شيوعاً في العالم، مع وجود ما يقدّر بـ1,5 مليار شخص مصاب بها في جميع أنحاء العالم، أو ما يعادل 24٪ من ...كان العالم. وتؤثر هذه الإصابات على أفقر المجتمعات وأكثرها حرماناً، حيث تعاني هذه المجتمعات من ضعف فرص الحصول على المياه النظيفة والصرف الصحي والنظافة الصحية في المناطق المدارية وشبه المدارية، مع الإبلاغ عن أعلى معدل انتشار لها في أفريقيا جنوب الصحراء الكبرى والصين وأمريكا الجنوبية وآسيا. وتنتقل العدوى عن طريق البيوض الموجودة في البراز البشري الذي يلوث التربة في المناطق التي تعاني من رداءة مرافق الصرف الصحي. ويعيش أكثر من 260 مليون طفل في سن ما قبل المدرسة، و654 مليون طفل في سن المدرسة، و108 ملايين مراهق، و138,8 مليون حامل ومرضع في مناطق تنتقل فيها هذه الطفيليات بشكل مكثف، ويحتاجون إلى العلاج والتدخلات الوقائية.
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Soil-transmitted helminth (STH) infections are among the most common infections worldwide and affect the poorest and most deprived communities. They are transmitted by eggs present in human faeces which in turn contaminate soil in areas where sanitation is poor.
Mycetoma - Report by the Secretariat - WHO
Accessed on 22.04.2023
To target helminth elimination, a new consortium of research institutes, universities, not-for-profit organizations, and pharmaceutical companies have joined forces and expertise to establish a research and development pipeline for the development of anthelminthics targeti...ng nematodes. The focus is on STH as well as onchocerciasis.
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Human African trypanosomiasis (HAT), also called sleeping sickness, is a parasitic infection that almost invariably progresses to death, unless treatment is provided. HAT caused devastating epidemics during the 20th century. Thanks to sustained and coordinated efforts during the past 15 years the nu...mber of reported cases has fallen to a historic low. Fewer than 3,000 cases were reported in 2015, and the disease is targeted for elimination by the World Health Organization. Despite recent success, HAT still poses a heavy burden on the rural communities where this highly focal disease occurs, most notably in Central Africa. Since patients are also reported from non-endemic countries outside Africa, HAT should be considered in differential diagnosis for all travellers, tourists, migrants and expatriates who have visited or lived in endemic areas. In the absence of a vaccine, disease control relies on case detection and treatment, and vector control. Available drugs are sub-optimal, but ongoing clinical trials give hope for safer and simpler treatments.
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Website last accessed on 08.05.2023
Identificar las formas de transmisión de la leishmaniasis - Youtube Video