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Mpox Testing Strategy - November 2024

Africa Center for Disease Control and Prevention (2024) CC

Mpox is an emerging zoonotic disease caused by the mpox virus, a member of the Orthopoxvirus genus closely related to the variola virus that causes smallpox. Mpox was first discovered in 1958 when outbreaks of a pox-like disease occurred in monkeys kept for research. The first human case was recorde...d in 1970 in the Democratic Republic of the Congo (DRC) during a period of intensified effort to eliminate smallpox and since then the infection has been reported in a number of African countries. Mpox can spread in humans through close contact, usually skin-to-skin contact, including sexual contact, with an infected person or animal, as well as with materials contaminated with the virus such as clothing, beddings and towels, and respiratory droplets in prolonged face to face contact. People remain infectious from the onset of symptoms until all the lesions have scabbed and healed. The virus may spread from infected animals through handling infected meat or through bites or scratches. Diagnosis is confirmed by polymerase chain reaction (PCR) testing of material from a lesion for the virus’s DNA. Two separate clades of the mpox virus are currently circulating in Africa: Clade I, which includes subclades Ia and Ib, and Clade II, comprising subclades IIa and IIb. Clade Ia and Clade Ib have been associated with ongoing human-to-human transmission and are presently responsible for outbreaks in the Democratic Republic of the Congo (DRC), while Clade Ib is also contributing to outbreaks in Burundi and other countries. In 2022‒2023 mpox caused a global outbreak in over 110 countries, most of which had no previous history of the disease, primarily driven by human-to-human transmission of clade II through sexual contact. In just over a year, over 90,000 cases and 150 deaths were reported to the WHO. For the second time since 2022, mpox has been declared a global health emergency as the virus spreads rapidly across the African continent. On 13 Aug 2024, Africa CDC declared the ongoing mpox outbreak a Public Health Emergency of Continental Security (PHECS), marking the first such declaration by the agency since its inception in 2017.7 This declaration empowered the Africa CDC to lead and coordinate responses to the mpox outbreak across affected African countries. On August 14, 2024, the WHO declared the resurgence of mpox a Public Health Emergency of International Concern (PHEIC) emphasizing the need for coordinated international response. As of August 2024, Mpox has expanded beyond its traditional endemic regions, with new cases reported in countries including Sweden, Thailand, the Philippines, and Pakistan. Sweden has confirmed its first case of Clade 1 variant, which has been rapidly spreading in Africa, particularly in DRC. The emergence of this new variant raises concerns about its potential for higher lethality and transmission rates outside Africa. more

Preventing HIV misdiagnosis: implementation guide

World Health Organization WHO (2024) CC

HIV testing programmes need to ensure that all clients who test for HIV are provided with correct diagnoses. The accuracy of HIV testing is critical to prevent misdiagnosis, as the consequences of giving an incorrect test result can be serious for clients, HIV testing services, HIV programmes and pu... more

Standards and recommendations for burns care in mass casualty incidents

World Health Organization WHO (2024) C_WHO

Caring for burns patients from the incident scene to definitive treatment can be a complex, resource-consuming process with the potential to overwhelm health system capacity.This document provides practical guidance for building capacity and capability for burns care from clinical, human resources a... more

Operational Guidance: Breastfeeding Counselling in Emergencies

Emergency Nutrition Network ENN (2021) C2

Women and children, especially pregnant girls and women, infants and young children and postpartum women, are populations that are extremely vulnerable in emergencies. Breastfeeding provides children with hydration, comfort, connection, high quality nutrition and protection against disease, shieldin... more

Essential and actionable measures for enhancing country preparedness for Viral Haemorrhagic Fever outbreaks in the WHO African Region
recommended

World Health Organization WHO (2024) C_WHO

The target audience of this document (and the associated online companion tool) includes WHO country offices in Member States of the African Region; Member States’ ministries of health and their public health emergency operation centres; relevant external assessment teams; and partners looking... more

Guideline on management of pneumonia and diarrhoea in children up to 10 years of age

World Health Organization WHO (2024) C_WHO

Pneumonia and diarrhoea account for 23% of under-five mortality and were responsible for an estimated 1.17 million deaths in children under five globally. Furthermore, pneumonia and diarrhoea were responsible for 18% of mortality in children 5–9 years of age, resulting in an estimated 86 000 preve... more

Targeted and selective strategies in measles and rubella vaccination campaigns: Interim guidance

World Health Organization WHO (2025) C_WHO

The World Health Organization provides regional and national strategies and operational plans that aim to support countries in work to achieve measles control and elimination. These are guided by high level frameworks including the Immunization Agenda 2030 and the Measles and Rubella Strategic Frame... more

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Nutrition Topic Guide

Jessica Meeker, Stephen Thompson, Inka Barnett The Health & Education Advice & Resource Team (HEART) (2013)

This Topic Guide has been compiled to provide an overview of undernutrition in the context of development. The focus of the Guide is on undernutrition, defined as the outcome of insufficient (quantity and quality) of food intake (hunger) and repeated infectious diseases. Undernutrition includes bein... more

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Uganda: UNICEF Annual Report 2015

UNICEF Uganda (2015) C1

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Status of Antiretroviral Therapy Service Delivery in Uganda

Ministry of Health, Uganda (2010) C1

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WHO policy on collaborative TB/HIV activities (Annexes)

World Health Organization (2012) C_WHO

Guidelines for national programmes and other stakeholders Annexes for webposting and CD-Rom distribution with the policy guidelines

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HIV and AIDS in Azerbaijan: A Socio-Cultural Approach

H. Drobna, C. Mallouris Culture and Development Section; Research Gate; UNESCO (2005) C2

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The People Living with HIV Stigma Index - Analytical report

I. Demchenko; O. Artiukh; T. Sosidko; et al. All-Ukraine Network of PLWH (2014) C2

Analytical report

Saudi Arabia National Action Plan on combating AMR

Ministry of Health Saudi Arabia (2017) C2

This action plan for the Kingdom Saudi Arabia to combat antimicrobial resistance has been formulated in the line of the WHO five objectives. It addresses the need for effective “one health” approach involving coordination among numerous national sectors and actors, including human and veterinary... more

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Situational Brief: Palestinian Refugees in the occupied Palestine Territories during Covid-19

Kaloti R., R. Kafri, H. Meghari (2020) CC

As of 12June 2020, there are 667confirmed COVID-19 casesin the OPT (565 of which are recovered cases), and 48% of which (320 cases) are in East Jerusalem and its suburbs. Additionally, there have been 5 reported COVID-19 deaths (1 in the West Bank, 1 in Gaza and 3 in East Jerusalem)

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National Policy and Strategic Plan of Action on Prevention and Control of Non-Communicable Diseases (NCDs) Nigeria

Federal Ministry of Health Nigeria (2013) CC

As part of our commitment to the fight against NCDs, Nigeria was signatory to the political declaration at the UN General Assembly High Level Meeting on NCDs in September 2011. Thus, the purpose of this document is to develop and ensure the implementation of policies and p... more

Enhancing the Role of Community Health Nursing for Universal Health Coverage

World Health Organisation (WHO) (2017) C_WHO

Community health nurses have the potential to make significant contributions to meet the health care needs of various population groups in a variety of community settings. In order to assess the extent to which CHNs are achieving this potential, WHO conducted a study between 2010 and 2014 that exami... more

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Investment guidelines for youth in agrifood systems in Africa

Food and Agriculture Organization of the United Nations FAO and African Union AU (2022) C1

The Investment guidelines for youth in agrifood systems in Africa, developed jointly by FAO and the African Union Commission (AUC) through a multi-stakeholder and participatory process, highlight the importance of youth as change agents and key stakeholders contributing to sustainable agrifood syste... more

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Key considerations: Indigenous Peoples in COVID-19 response and recovery

Social Science in Humanitarian Action Platform (2021) C2

English Analysis on Brazil about Health, Protection and Human Rights and Epidemic; published on 26 May 2021 by SSHAP

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National Guidelines for Diabetic Eye Care

Ministry of Health Malawi (2021) CC

Diabetes mellitus (DM) is a global epidemic with significant morbidity. Diabetic retinopathy (DR) is the specific microvascular complication of DM and affects 1 in 3 persons with DM. DR remains a leading cause of vision loss in working adult populations. Patients with severe levels of DR are report... more

Essential and actionable measures for enhancing country preparedness for Viral Haemorrhagic Fever outbreaks in the WHO African Region recommended

Essential and actionable measures for enhancing country preparedness for Viral Haemorrhagic Fever outbreaks in the WHO African Region
recommended