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Mpox Testing Strategy - November 2024

Africa Center for Disease Control and Prevention (2024) CC

Mpox is an emerging zoonotic disease caused by the mpox virus, a member of the Orthopoxvirus genus closely related to the variola virus that causes smallpox. Mpox was first discovered in 1958 when outbreaks of a pox-like disease occurred in monkeys kept for research. The first human case was recorde...d in 1970 in the Democratic Republic of the Congo (DRC) during a period of intensified effort to eliminate smallpox and since then the infection has been reported in a number of African countries. Mpox can spread in humans through close contact, usually skin-to-skin contact, including sexual contact, with an infected person or animal, as well as with materials contaminated with the virus such as clothing, beddings and towels, and respiratory droplets in prolonged face to face contact. People remain infectious from the onset of symptoms until all the lesions have scabbed and healed. The virus may spread from infected animals through handling infected meat or through bites or scratches. Diagnosis is confirmed by polymerase chain reaction (PCR) testing of material from a lesion for the virus’s DNA. Two separate clades of the mpox virus are currently circulating in Africa: Clade I, which includes subclades Ia and Ib, and Clade II, comprising subclades IIa and IIb. Clade Ia and Clade Ib have been associated with ongoing human-to-human transmission and are presently responsible for outbreaks in the Democratic Republic of the Congo (DRC), while Clade Ib is also contributing to outbreaks in Burundi and other countries. In 2022‒2023 mpox caused a global outbreak in over 110 countries, most of which had no previous history of the disease, primarily driven by human-to-human transmission of clade II through sexual contact. In just over a year, over 90,000 cases and 150 deaths were reported to the WHO. For the second time since 2022, mpox has been declared a global health emergency as the virus spreads rapidly across the African continent. On 13 Aug 2024, Africa CDC declared the ongoing mpox outbreak a Public Health Emergency of Continental Security (PHECS), marking the first such declaration by the agency since its inception in 2017.7 This declaration empowered the Africa CDC to lead and coordinate responses to the mpox outbreak across affected African countries. On August 14, 2024, the WHO declared the resurgence of mpox a Public Health Emergency of International Concern (PHEIC) emphasizing the need for coordinated international response. As of August 2024, Mpox has expanded beyond its traditional endemic regions, with new cases reported in countries including Sweden, Thailand, the Philippines, and Pakistan. Sweden has confirmed its first case of Clade 1 variant, which has been rapidly spreading in Africa, particularly in DRC. The emergence of this new variant raises concerns about its potential for higher lethality and transmission rates outside Africa. more

Integrating disease outbreaks and strengthening of health in whole-of-society disaster risk management

UN Office for Disaster Risk Reduction (2024) CC

The guide aims to provide health and DRM practitioners, planners and policymakers across sectors with targeted information to help them strengthen national health systems and integrate the risks of disease outbreaks in national DRR strategies The following are some of the principles and approache... more

A comprehensive review of cystic fibrosis in Africa and Asia

Abubakar, B.K.; Ahmad, U., Chau, D.M. et al. Saudi Journal of Biological Sciences (2023) CC

Cystic ﬁbrosis (CF) was earlier thought to be a disease prevalent in the West among Caucasians. However, quite a number of recent studies have uncovered CF cases outside of this region, and reported hundreds of unique and novel variant forms of CFTR. Here, we discuss the evidence of CF in parts of... more

Femicides in 2023: Global Estimates of Intimate Partner/Family Member Femicides
recommended

UN Women Reliefweb OCHA (2024) C2

Globally, 85,000 women and girls were killed intentionally in 2023. 60 per cent of these homicides—51,000—were committed by an intimate partner or other family member. 140 women and girls die every day at the hands of their partner or a close relative, which means one woman or girl is killed eve... more

Considerations for wastewater and environmental surveillance for monkeypox virus: interim guidance, 25 November 2024

World Health Organization WHO (2024) C_WHO

interim guidance, 25 November 2024

Guideline on management of pneumonia and diarrhoea in children up to 10 years of age

World Health Organization WHO (2024) C_WHO

Pneumonia and diarrhoea account for 23% of under-five mortality and were responsible for an estimated 1.17 million deaths in children under five globally. Furthermore, pneumonia and diarrhoea were responsible for 18% of mortality in children 5–9 years of age, resulting in an estimated 86 000 preve... more

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WHO Recommendations for the Prevention and Treatment of Postpartum Haemorrhage
recommended

World Health Organization WHO (2012) C_WHO

To provide a foundation for the strategic policy and programme development needed to ensure the sustainable implementation of effective interventions for reducing the global burden of PPH

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Food Security Program Lifecycle Toolkit

Food for the Hungry (2006) CC

It is our hope and prayer that the guidance and multiple tools provided herein to manage the entire lifecycle of a food security program are useful to our food security staff, our local partners, and our fellow international Cooperating Sponsors throughout the world.

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The Handwashing Handbook

The Global Public Private Partnership for Handwashing The World Bank Group (2020) CC

A guide for developing a hygiene promotion program to increase handwashing with soap

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Malaria Control in Humanitarian Emergencies. An Inter-Agency Field Handbook
recommended

Jose Nkuni, Natasha Howard, Abraham Mnzava et al. World Health Organization (2013) C_WHO

2nd edition. The interagency field handbook on malaria control was developed to set out effective malaria control responses in humanitarian emergencies, particularly during the acute phase when reliance on international humanitarian assistance is greatest. This second edition represents a thorough u... more

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The Humanitarian Emergency Settings Perceived Needs Scale (HESPER)

World Health Organization WHO (2011) C_WHO

Manual with Scale

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Essential Guide to Humanitarian Good Practice, 5th ed.
recommended

All in Diary (AID) (2016) C2

A practical tool for field based humanitarian workers. It provides up-to-date, clear and succint guidance on topics accross the humanitarian sector including references to current, relevant resources and practical tools.

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Oxfam's Approach to Nutrition Surveys in Emergencies

Susanne Jaspars and Hisham Khogali Oxfam (2001) C1

Nutrition Surveys

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Tuberculosis. Practical guide for clinicians, nurses, laboratory technicians and medical auxiliaries

Médecins sans Frontières MSF (2022) C2

This Tuberculosis guide has been developed jointly by Médecins Sans Frontières and Partners In Health. It aims at providing useful information to the clinicians and health staff for the comprehensive management of tuberculosis. Forms of susceptible and resistant tuberculosis, tuberculosis in child... more

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Guidelines for Addressing HIV in Humanitarian Settings (IASC)
recommended

Inter-Agency Standing Committee UNAIDS (2010)

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Humanitarian Supply Management And Logistics In The Health Sector
recommended

Pan American Health Organization (2001)

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Helminth control in school age children: a guide for managers of control programmes

WHO (2011)

2nd ed.

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Consolidated guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection
recommended

World Health Organization WHO (2016) C_WHO

2nd edition. These guidelines provide guidance on the diagnosis of human immunodeficiency virus (HIV) infection, the use of antiretroviral (ARV) drugs for treating and preventing HIV infection and the care of people living with HIV. They are structured along the continuum of HIV testing, prevention,... more

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Cholera Outbreak Guidelines Preparedness, Prevention and Control
recommended

Elizabeth Lamond, and Jesee Kinyanjui Oxfam (2012) C1

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The Role of Laboratories and Blood Banks in Disaster Situations

Pan American Health Organization (2001) C_WHO

Femicides in 2023: Global Estimates of Intimate Partner/Family Member Femicides recommended

WHO Recommendations for the Prevention and Treatment of Postpartum Haemorrhage recommended

Malaria Control in Humanitarian Emergencies. An Inter-Agency Field Handbook recommended

Essential Guide to Humanitarian Good Practice, 5th ed. recommended

Guidelines for Addressing HIV in Humanitarian Settings (IASC) recommended

Humanitarian Supply Management And Logistics In The Health Sector recommended

Consolidated guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection recommended

Cholera Outbreak Guidelines Preparedness, Prevention and Control recommended