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Therapeutics and COVID-19 (Living Guideline, 10 November 2023)

World Health Organization WHO (2023) C_WHO

WHO has updated its guidelines for COVID-19 therapeutics, with revised recommendations for patients with non-severe COVID-19. This is the 13th update to these guidelines. Updated risk rates for hospital admission in patients with non-severe COVID-19 The guidance includes updated risk rates for... hospital admission in patients with non-severe COVID-19. The current COVID-19 virus variants tend to cause less severe disease while immunity levels are higher due to vaccination, leading to lower risks of severe illness and death for most patients. This update includes new baseline risk estimates for hospital admission in patients with non-severe COVID-19. The new ‘moderate risk’ category now includes people previously considered to be high risk including older people and/or those with chronic conditions, disabilities, and comorbidities of chronic disease. The updated risk estimates will assist healthcare professionals to identify individuals at high, moderate or low risk of hospital admission, and to tailor treatment according to WHO guidelines: **High: **People who are immunosuppressed remain at higher risk if they contract COVID-19, with an estimated hospitalization rate of 6%. **Moderate: **People over 65 years old, those with conditions like obesity, diabetes and/or chronic conditions including chronic obstructive pulmonary disease, kidney or liver disease, cancer, people with disabilities and those with comorbidities of chronic disease are at moderate risk, with an estimated hospitalization rate of 3%. Low: Those who are not in the high or moderate risk categories are at low risk of hospitalization (0.5%). Most people are low risk. Review of COVID-19 treatments for people with non-severe COVID-19 WHO continues to strongly recommend nirmatrelvir-ritonavir (also known by its brand name ‘Paxlovid’) for people at high-risk and moderate risk of hospitalization. The recommendations state that nirmatrelvir-ritonavir is considered the best choice for most eligible patients, given its therapeutic benefits, ease of administration and fewer concerns about potential harms. Nirmatrelvir-ritonavir was first recommended by WHO in April 2022. If nirmatrelvir-ritonavir is not available to patients at high-risk of hospitalization, WHO suggests the use of molnupiravir or remdesivir instead. WHO suggests against the use of molnupiravir and remdesivir for patients at moderate risk, judging the potential harms to outweigh the limited benefits in patients at moderate risk of hospital admission. For people at low risk of hospitalization, WHO does not recommend any antiviral therapy. Symptoms like fever and pain can continue to be managed with analgesics like paracetamol. WHO also recommends against use of a new antiviral (VV116) for patients, except in clinical trials. The update also includes a strong recommendation against the use of ivermectin for patients with non-severe COVID-19. WHO continues to advise that in patients with severe or critical COVID-19, ivermectin should only be used in clinical trials. more

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Therapeutics for Ebola virus disease
recommended

World Health Organization WHO (2022) C_WHO

The WHO Ebola Virus Disease (EVD) Clinical management: living guidance contains the Organization’s most up-to-date recommendations for the clinical management of people with EVD. Providing guidance that is comprehensive and holistic for the optimal care of patients with EVD throughout their il... more

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Maintaining essential health services: operational guidance for the COVID-19 context interim guidance

WHO (2021) CC

Countries around the world are facing the challenge of increased demand for care of people with COVID-19, compounded by fear, misinformation and limitations on movement that disrupt the delivery of health care for all conditions. Maintaining essential health services: operational guidance for the CO... more

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ARTs Based Therapy for Survivors of Trauma and Abuse in Government and NGO-Run Children's Home for Girls in Delhi

Save the Children (2016) C1

This article identifies the three core defining characteristics of healing environments for children and young people who have been exposed to chronic adversity and trauma. A large body of evidence highlights the pervasive and devastating developmental impacts of such exposure but there is also emer... more

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Maintaining essential health services: operational guidance for the COVID-19 context
recommended

World Health Organization WHO (2020) C_WHO

1 June 2020 Countries around the world are facing the challenge of increased demand for care of people with COVID-19, compounded by fear, misinformation and limitations on movement that disrupt the delivery of health care for all conditions. Maintaining essential health services: operational guidan... more

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Ukraine - Humanitarian Response Plan 2022 (February 2022)

Office for the Coordination of Humanitarian Affairs OCHA (2022) C1

Almost eight years of active fighting have had profound consequences on the lives of millions of people in the conflict-affected Donetska and Luhanska oblasts of eastern Ukraine. An estimated 2.9 million people are projected to need humanitarian assistance in 2022, with some 55 per cent living in th... more

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Stratégie d’éradication de la poliomyélite 2022–2026: Tenir notre promesse

Global Polio Eradication Initiative GPEI; Organisation mondiale de la Santé (2022) C_WHO

The marathon to eradicate polio is on its final lap: the world is more than 99% of the way to success. After millennia of living with poliovirus and suffering the paralysis it causes, today nearly all the world’s people live in polio-free countries; two of the three strains of wild poliovirus (WPV... more

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Childhood Disability and Poverty

Daniel Mont Leonard Cheshire Disability and Inclusive Development Centre (2014) C2

As the Convention of the Rights of Children recognizes, children are human beings with a distinct set of rights, and not the passive objects of care and charity. They deserve to be full participants in society, and to live lives free of poverty. But for children, living in poverty is particularly im... more

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Guideline ‒ Alternative mass drug administration regimens to eliminate lymphatic filariasis
recommended

World Health Organization WHO (2017) C_WHO

Lymphatic filariasis is a vector-borne neglected tropical disease that causes damage of the lymphatic system and can lead to lymphoedema (elephantiasis) and hydrocele in infected individuals. The global baseline estimate of persons affected by lymphatic filariasis is 25 million men with hydrocele an... more

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National Strategic Plan for HIV/AIDS and STI 2017 – 2024: “Paving Way for an AIDS Free India”

Government of India, Ministry of Health and Family Welfare, National AIDS Control Organisation (NACO) (2017) C1

The National Strategic Plan for HIV/AIDS and STIs 2017-2024 spells out the objectives and targets that we have jointly committed to achieve. The plan describes the strategies and activities that will need to be implemented on the ground across India's 36 States and Union Territories with the help of... more

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Towards a Common Language for Functioning, Disability and Health: ICF (The International Classification of Functioning, Disability and Health)

World Health Organization (WHO) (2002) C_WHO

The International Classification of Functioning, Disability and Health, known more commonly as ICF, provides a standard language and framework for the description of health and health-related states. Like the first version published by the World Health Organization for trial purposes in 1980, ICF is... more

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Rohingya Refugee Crisis Response Plan - Monitoring Report 25

Inter Sector Coordination Group (ISCG) (2017) C1

The Monitoring Report, which covers the first two months of the response from 25 August to 31 October, highlights the work of the Government of Bangladesh, in cooperation with humanitarian partners who are working to provide relief services for the refugee population and Bangladeshi host communities... more

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Dementia - A public health priority

World Health Organization; Alzheimer's Disease International (2012) C_WHO

The report “Dementia: a public health priority” has been jointly developed by WHO and Alzheimer's Disease International. The purpose of this report is to raise awareness of dementia as a public health priority, to articulate a public health approach and to advocate for action at international a... more

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Global air pollution exposure and poverty

Rentschler, J.; Leonova, N. Nature Communications (2023) CC

Air pollution is one of the leading causes of health complications and mortality worldwide, especially affecting lower-income groups, who tend to be more exposed and vulnerable. This study documents the relationship between ambient air pollution exposure and poverty in 211 countries and territories.... more

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The Effects of Severe Burns on Levels of Activity

Hooman Ghrobani, Mahnoush Momeni, Ali Zavareh, Mahshid Aghajanzadeh, Maryam Roham, Hamid Karimi, Hossein Rahbar Disability, CBR & Inclusive Development Journal (DCIDJ) (2017) CC

With the recent advances in medicine, the survival rate of clients with severe burns has improved. This has resulted in greater demand for rehabilitation services. One of the major goals for rehabilitation programmes is to restore these clients to their pre-trauma activity levels. However, there is... more

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Medicinal herbs used by HIV-positive people in Lesotho

Mugomeri, Eltony ; Chatanga, Peter; Chakane, Ntema (2016) CC

Afr J Tradit Complement Altern Med. (2016) 13(4):123-131
Out of 400 questionnaires distributed to the participants, 389 were returned with data acceptable for analysis. Ages of the participants ranged from 18 to 75 years (Mean=43 + 11.6). Out of the 272 (69.9%) participants who conceded that th... more

Therapeutics for Ebola virus disease recommended

Maintaining essential health services: operational guidance for the COVID-19 context recommended

Guideline ‒ Alternative mass drug administration regimens to eliminate lymphatic filariasis recommended

Therapeutics for Ebola virus disease
recommended

Maintaining essential health services: operational guidance for the COVID-19 context
recommended

Guideline ‒ Alternative mass drug administration regimens to eliminate lymphatic filariasis
recommended