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Snakebite epidemiology, outcomes and multicluster risk modelling in Eswatini

Padidar S.; Monadjem A.; Litschka-Koen T. PLOS (2023) CC

Halving snakebite morbidity and mortality by 2030 requires countries to develop both prevention and... more

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Infrastructure, policy and regulatory interventions to increase physical activity to prevent cardiovascular diseases and diabetes: a systematic review

Durão, S.; Burns, J.; Schmidt, B. et al. BMC Public Health (2023) CC

Background Noncommunicable diseases are major contributors to morbidity and mortality worldwide. Modifying the risk factors for these conditions, ...such as physical inactivity, is thus essential. Addressing the context or circumstances in which physical activity occurs may promote physical activity at a population level. We assessed the effects of infrastructure, policy or regulatory interventions for increasing physical activity. Methods We searched PubMed, Embase and clinicaltrials.gov to identify randomised controlled trials (RCTs), controlled before-after (CBAs) studies, and interrupted time series (ITS) studies assessing population-level infrastructure or policy and regulatory interventions to increase physical activity. We were interested in the effects of these interventions on physical activity, body weight and related measures, blood pressure, and CVD and type 2 diabetes morbidity and mortality, and on other secondary outcomes. Screening and data extraction was done in duplicate, with risk of bias was using an adapted Cochrane risk of bias tool. Due to high levels of heterogeneity, we synthesised the evidence based on effect direction. Results We included 33 studies, mostly conducted in high-income countries. Of these, 13 assessed infrastructure changes to green or other spaces to promote physical activity and 18 infrastructure changes to promote active transport. The effects of identified interventions on physical activity, body weight and blood pressure varied across studies (very low certainty evidence); thus, we remain very uncertain about the effects of these interventions. Two studies assessed the effects of policy and regulatory interventions; one provided free access to physical activity facilities and showed that it may have beneficial effects on physical activity (low certainty evidence). The other provided free bus travel for youth, with intervention effects varying across studies (very low certainty evidence). Conclusions Evidence from 33 studies assessing infrastructure, policy and regulatory interventions for increasing physical activity showed varying results. The certainty of the evidence was mostly very low, due to study designs included and inconsistent findings between studies. Despite this drawback, the evidence indicates that providing access to physical activity facilities may be beneficial; however this finding is based on only one study. Implementation of these interventions requires full consideration of contextual factors, especially in low resource settings. more

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Antibiotic Use for Sepsis in Neonates and Children: 2016 Evidence Update

Fuchs A., J. Bielickia, S. Mathur, et.al. World Health Organization (2016) C_WHO

Sepsis remains a leading cause of mortality and morbidity, especially during the first five days of life ... in low and middle-income countries (LMIC) [1]. Hospital infection also remains a major cause of mortality in children despite progress encountered in the last decades. more

Landscape analysis of pregnancy exposure registries in low- and middle-income countries

World Health Organization WHO (2024) C_WHO

Many vaccines and drugs hold the promise of reducing mortality and morbidity among pregnant wome... more

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Provisional CDC Guidelines for the Use and Safety Monitoring of Bedaquiline Fumarate (Sirturo) for the Treatment of Multidrug-Resistant Tuberculosis

Centers for Disease Control and Prevention (2013) C_CDC

MMWR: Recommendations and Reports / Vol. 62 / No. 9 Morbidity and Mortality Weekly Report Octo... more

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A comparison of cardiovascular imaging practices in Africa, North America, and Europe: two faces of the same coin

Lakshmanan, S.; Mbanze, I. European Society of Cardiology (2023) CC

Cardiovascular diseases remain the leading cause of morbidity and mortality worldwide. There are significant differences in the burden of cardiovas... more

The availability, cost, and affordability of essential medicines for asthma and COPD in low-income and middle-income countries: a systematic review

Stolbrink, M.; Thomson, H.; Hadfield, R.M. et al. The Lancet Global Health (2022) CC

Background: Asthma and chronic obstructive pulmonary disease (COPD) cause a considerable burden of morbidity and ... in low-income and middle-income countries (LMICs). Access to safe, effective, quality-assured, and affordable essential medicines is variable. We aimed to review the existing literature relating to the availability, cost, and affordability of WHO’s essential medicines for asthma and COPD in LMICs. more

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Interim Guidelines for the Evaluation and Testing of Infants with Possible Congenital Zika Virus Infection

Staples JE, Dziuban EJ, Fischer M, et al (2016) C2

A printable copy of the article published in Morbidity and Mortality Weekly Report (MMWR) can be found on the CDC Homepage. Follow the Download Lin... more

Prevention, Screening and Control of Common Non-Communicable Diseases: Hypertension, Diabetes an Common Cancers (Oral, Breast, Cervix)

National Health Mission (2016) CC

Comprehensive Primary Health Care has an important role in the primary and secondary prevention of several disease conditions, including non-communicable diseases which today contribute to over 60% of the ... in India. The provision of Comprehensive primary health care reduces morbidity, disability and mortality at much lower costs and significantly reduces the need for secondary and tertiary care. Estimates suggest that almost 52% of all conditions can be managed at the primary care level. In order to ensure comprehensive primary health care, close to where people live, Sub- Centres should be strengthened as Health and Wellness Centres (H&WC), staffed by appropriately trained primary health care team. The Medical officer of the Primary Health Centre would oversee the functioning of the SC/HWC that falls in that area. Services include those that (i) can be delivered at the level of the household and outreach sites in the community by suitably trained frontline workers, (ii) those that are delivered by a team headed by a mid-level health provider, at the level of the Sub-Centre/Health and Wellness Centre and (iii) the referral support and continuity of care within the district health system in rural and urban areas. The package of services is in Box. States would need to either phase in these services or add on additional services based on state specific and local context. more

Understanding and controlling asthma in Latin America: A review of recent research informed by the SCAALA programme

Cooper, P. J.; Figueiredo, C. A.; Rodriguez, A.; et al. (2023) CC2

Asthma is the most common chronic respiratory disease (CRD) worldwide and is estimated to affect 262 million causing significant mortality and ..., and has emerged as an important public health problem in many Latin American (LA) countries over the last 30 or so years. LA is a highly diverse region in terms of geography, climate, wealth, and ethnicity including 20 different countries with 639 million inhabitants, where 40 million are estimated to have asthma. A common feature of LA countries is the high level of social inequalities3 (Figure 1). In LA, asthma prevalence in both children and adults is highly variable and, where high, is among the highest worldwide, particularly in coastal tropical cities. more

Global, regional, and national prevalence of, and risk factors for, chronic obstructive pulmonary disease (COPD) in 2019: a systematic review and modelling analysis

Adeloye, D.; Song, P.; Zhu, Y. et al. (2022) CC2

Chronic obstructive pulmonary disease (COPD) is an increasingly important cause of morbidity, disability, and mortality worldwide. We aimed to esti... more

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Guidelines for the Diagnosis and Treatment of Malaria in Somalia

Federal Government of Somalia, Puntland & Somaliland, Zonal NMCPsMoH (2016) C1

The main objective of the malaria prevention and control programme in Somalia is to prevent mortality and reduce ... due to malaria. The groups most vulnerable to the disease, children aged under 5 years and pregnant women, are especially targeted. Effective case management - early diagnosis and treatment - is a critical component of malaria prevention and control. To achieve the main objective of reducing malaria morbidity and prevention of malaria mortality, the availability of safe, effective, affordable and accessible anti-malarial drugs is a prerequisite. more

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Cardiovascular medicine and research in sub-Saharan Africa: challenges and opportunities

Zühlke, L.; Sliwa, K.; Naidoo, P. et al. Nature Reviews Cardiology (2019) CC

Africa is witnessing an epidemic of cardiovascular disease (CVD), with staggering morbidity and mortality. The spectrum of CVD includes hypertensio... more

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Early Diagnosis of Cancer in Childhood and Adolescence

Pan American Health Organization PAHO (2021) C_WHO

The purpose of this course is to contribute to the reduction of morbidity and mortality in children and... adolescents with cancer by strengthening the capacities of healthcare professionals on the early diagnosis of cancer with concepts and learning instruments that allow them to recognize the signs and symptoms of cancer in a timely and early manner. more

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Research and Evaluation Agenda for HIV and Maternal Health in sub-Saharan Africa

Kendall, Tamil; Danel, Isabella (2014) C1

Women and Health Initiative Working Paper No. 1. Women and Health Initiative
Improving maternal health in the context of the sub-Saharan African HIV epidemic requires greater understanding of the... more

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National Multisectoral Action Plan (NMAP) for Prevention and Control of Common NCDs (2017-22)

Ministry of Health and Family Welfare Government of India; WHO (2017) C_WHO

India is experiencing rapid demographic and epidemiological transitions with NCDs causing significant disability, morbidity and ... both in urban and rural populations and across all socioeconomic strata. According to the ICMR State Level Disease Burden Initiative, in 2016, NCDs accounted to an estimated 6.0 million deaths, constituting 62% of the total mortality of that year. more

Diarrhea and Dehydration Module 6

Yu C, Lougee D, Murno JR American Academy of Pediatrics (2016) C1

Poor sanitary conditions in disaster-stricken areas result in higher risk for diarrheal illness in vulnerable populations, especially children. This disease negatively impacts the nutritional status of affected children and cause... more

Guidelines for diagnosing, preventing and managing cryptococcal disease among adults, adolescents and children living with HIV. Policy brief
recommended

World Health Organization WHO (2022) C_WHO

Cryptococcal disease, particularly cryptococcal meningitis is a significant cause of morbidity and mortality among people living with HIV with adva... more

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Recommendations for Establishing a National Maternal Near-miss Surveillance System in Latin America and the Caribbean

Pan American Health Organization (PAHO) (2022) C_WHO

Maternal mortality has fallen significantly in recent years, especially in countries that have emphasized the prevention of its main causes, such as hemorrhagic and infectious complications ... hypertension , including in the Region of the Americas. In its final report on the Plan of Action to Accelerate the Reduction of Maternal Mortality and Severe Maternal Morbidity, the Pan American Health Organization (PAHO) reported a continuing downward trend in maternal mortality, with an 18.1% reduction in the maternal morbidity ratio during the period 2010-2015 . From a pathophysiological perspective, death events are a common end result of a wide spectrum of complications leading to multi-organ dysfunction. However, there is a group of women in this situation who survive, despite the seriousness of their condition. This high number of patients––who were in serious condition but did not die––reflects the actual health conditions in an institution or a country. For this reason, there is a need to create indicators to estimate morbidity in women due to diseases and incidents that occur during pregnancy, childbirth, and the puerperium. To this end, we propose conducting epidemiological surveillance of an indicator that includes women who survived after presenting a potentially fatal complication during pregnancy, childbirth, or the puerperium, reflecting quality medical attention and care (5, 6). This indicator is maternal near-miss (MNM), which refers to extremely severe maternal morbidity––cases of a severity that brings women very close to the death event. After adjusting the definition to a specific population and time, MNM is defined as a case in which a woman nearly died, but survived a complication that occurred during pregnancy, childbirth, or within 42 days of termination of pregnancy more

Guidelines for diagnosing, preventing and managing cryptococcal disease among adults, adolescents and children living with HIV. Policy brief recommended

Guidelines for diagnosing, preventing and managing cryptococcal disease among adults, adolescents and children living with HIV. Policy brief
recommended