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COVID-19 Vaccines: 1 Safety Surveillance 2 Manual While there is no indication that pregnant women have an increased susceptibility to infection with SARS-CoV-2, there is evidence that pregnancy may increase the risk of severe illness and mortality ... more
13 July 2021 The module provides an overview of factors to consider when monitoring the safety of COVID-19 vaccines administered to pregnant and breastfeeding women. It describes how national routine AEFI surveillance should be adapted to cater fo ... more
Injection practices worldwide and especially in low- and middle-income countries (LMICs) include multiple, avoidable unsafe practices that ultimately lead to the large-scale transmission of bloodborne viruses among patients, health care providers and the community at large.
Maintaining proper storage conditions for health commodities is vital to ensuring their quality. Product expiration dates are based on ideal storage conditions and protecting product quality until their expiration date is important for serving customers and conserving resources. Guidelines for the S ... more
World Journal of Pharmaceutical and Medical Research vol. 5 (2019) 3, 129-132
A desk guide for health facilities . It outlines a comprehensive approach to respiratory health, which health facilities can adapt and implement in resource-limited settings
During fresh fruit and vegetables (FFV) production, water is used for a variety of purposes. Even the water was conventionally treated and disinfected, it may still potentially contain human pathogens, albeit at low concentrations. A risk assessment, appropriate to the national or local production c ... more
Today, patient harm due to unsafe care is a large and growing global public health challenge and is one of the leading causes of death and disability worldwide. Most of this patient harm is avoidable. As countries strive to achieve universal health coverage and the Sustainable Development Goals, t ... more
The coronavirus disease (COVID-19) pandemic exacerbated pre-existing inequalities in the treatment and care of noncommunicable diseases (NCDs). This report examines the effect of the COVID-19 pandemic on access to NCD medicines, and the policies and ... more
Factors to take into account when choosing, reviewing and changing medicines. Rescue therapy: For symptomatic hyperglycaemia, consider insulin or a sulfonylurea and review when blood glucose control has been achieved. Diet and lifestyle advice: ... more
The coronavirus disease (COVID-19) pandemic exacerbated pre-existing inequalities in the treatment and care of noncommunicable diseases (NCDs). This report examines the effect of the COVID-19 pandemic on access to NCD medicines, and the policies and ... more
Fourth Edition
The "Primary Healthcare Standard Treatment Guidelines and Essential Medicines List" by the South African National Department of Health provides evidence-based guidelines for diagnosing and managing common medical conditions at the primary healthcare ... more
International Review of the Red Cross Volume 91 Number 874 June 2009
6th edition
Fourth Edition
The Kenya Essential Medicines List 2019 is an indispensable guide to the medicines recommended for the management of common conditions in Kenya. It is primarily directed at health care providers and ... more
The essential medicines are those that meet the priority needs of the healthcare of the population. While reviewing the 5th edition of the essential Medicines, special attention focused on the heal ... more
SCOPING QUESTION: For adults and children with medication-resistant convulsive epilepsy, which anti-epileptic medications produce benefits and/or harm in the specified outcomes when compared to a placebo or a comparator?

Drug use and road safety

World Health Organization (2016) C_WHO
Psychoactive substance use affects the functioning of the brain and leads to impaired driving
WHO today published the new edition of its Model Lists of Essential Medicines and Essential Medicines for Children, which include new treatments for various cancers, insulin analogues and new oral ... more
Research Article PLOS ONE | DOI:10.1371/journal.pone.0164619 October 13, 2016
Using the WHO model list of essential medicines to update a national essential medicines list Since 1977, WHO has been working with countries to design the package of essential ... more
28 Dec 2020. The main objective of these guidelines is to provide tools for staff working in the field of immunization to support effective communication between health personnel and the general population, with the aim of strengthening, maintaining or recovering trust in vaccines and the immunizati ... more
100 test methods for 100 active pharmaceutical ingredients For existing Minilab projects that want to replace old manuals or initiatives that want to start new projects, the new "Minilab Edition 2020" can be obtained at the preferential price of 50 € from our logistic partner Technologie Transfer ... more
The procurement of essential medicines and other health products is a critical function in support of the effective discharge of WHO’s mandate, and WHO values the importance of the quality of essential m ... more
This guidance should be followed if an unlicensed medicine is prepared in a registered pharmacy. The preparation of an unlicensed medicine (for example unlicensed methadone, or menthol in aqueous cream) in a pharmacy is called ‘extemporaneous preparation’. The guidance should be read alon ... more

The World Medicines Situation 2011

Milani, B.; and W. Scholten World Health Organization WHO (2011) CC
Access to controlled medicines. 3rd edition
Annex 5, WHO Technical Report Series 1010, 2018
Med J DY Patil Univ 2017;10:229-33
The incidence and mortality of cardiovascular diseases (CVDs) in low and middle income countries (LMICs) have been increasing, while access to CVDs medicines is suboptimal. We assessed selection of essential ... more

Improving Access to and Appropriate Use of Medicines for Mental Disorders

Corrado Barbui, Tarun Dua, Kavitha Kolappa et al. World Health Organization and Calouste Gulbenkian Foundation (2017) C_WHO
Interagency Guidelines - This revised Interagency List of Essential Medicines for Reproductive Health presents the current international consensus on rational selection of essential reproductive health m ... more
Direct acting antivirals (DAAs) have revolutionized treatment for hepatitis C. Combi- nations of DAAs can cure infection with HCV in 12 weeks, are highly effective and have limited side-effects. Affordability of DAAs has improved significantly, but access remains lim- i ... more
The new guidelines provide public health guidance on pharmacological agents for managing hyperglycaemia in type 1 and type 2 diabetes for use in primary health-care in low-resource settings. These guidelines update the recommendations for managing hyperglycaemia in the WHO Package of Essential NCD I ... more
9 April 2020 WHO has published the guidance “Clinical management of severe acute respiratory infection (SARI) when COVID-19 disease is suspected” This document is intended for clinicians taking care of hospitalized adult and paediatric patients with severe acute respiratory infection (SARI) whe ... more
Two test methods on dexamethasone tablets and injections
7 April 2021 Based on current information, a causal relationship between the vaccine and the occurrence of blood clots with low platelets is considered plausible but is not confirmed. Available in Englisch, French and Russian
Technology landscape
WHO recently conducted a survey to assess the availability and cost of a national tracer list of essential medicines in the outpatient sector in Ukraine using a new collection tool – the WHO Essential Me ... more
Millennium Development Goal 8E aims for affordable access to essential medicines. Essential medicines, as defined by WHO, are those that “satisfy the health-care needs of the majority of the popul ... more
Report: A survey conducted among the 27 high MDR-TB burden countries. March – July 2015 Stop TB Partnership in collaboration with Medecins Sans Frontieres (MSF). Accessed November 2017.
This article examines the activities of national and international actors in Pharmaceutical Services (PS) in Mozambique from 2007 to 2012, focusing on the public provision of HIV/Aids, malaria and tuberculosis medicines. It describes how PS function ... more
Full eHandbook under: http://www.msh.org/resources/health-systems-in-action-an-ehandbook-for-leaders-and-managers Effective supply management has the potential to make a powerful contribution to the reliable availability of essential medicines, whi ... more
Annex 7
Severe Acute Malnutrition (SAM) is one of the greatest child survival challenges in the world today and reportedly affects more than 16.2 million children each year1. High impact, proven treatment interventions exist yet sadly approximately only 3.2 million children with SAM have access to treatme ... more
Accessed at 25.03.2014
4th edition. This report – now in its fourth edition – analyses the barriers and factors affecting access to treatment regimens for drug-resistant tuberculosis (DR-TB), including new and repurposed drugs. We provide detailed pricing profiles of key DR-TB drugs, using manufacturer responses to s ... more
Procurement and supply management activities are fundamental to consistent and reliable access to essential medicines and health products. To reduce the impact of CVD, action needs to be taken to improve prevention, diagnosis, care and management of ... more
Afr J Tradit Complement Altern Med. (2013) 10(5):210-229
Plants are important sources of medicines. Herbal medicines in Lesotho are exposed to excessive exploitation and habitat destruction. C ... more

How to take medicines safely

German Agency for Quality in Medicine (ÄZQ) (2011) C1
Patient information on safe medical treatment. Available in: Arabic, English, French, Russian, Spanish, Turkish, German. This is the English version. For other language versions visit: http://www.patienten-information.de/kurzinformationen/arzneimittel-und-impfungen/sichere-arzneimitteltherapie
Accessed November 2017
REG 174 INFORMATION FOR UK HEALTHCARE PROFESSIONALS
7 April 2021
The Zimbabwe National Pharmacovigilance Policy Handbook, 2nd Edition updates the November 2013 version to indicate the Zimbabwe National Pharmacovigilance (PV) Centre’s compliance with the WHO Pharmacovigilance Indicators Handbook 2015.
Introduction Pharmacovigilance (PV) systems to monitor drug and vaccine safety are often inadequate in sub-Saharan Africa. In Malawi, a PV enhancement initiative was introduced to address major barriers to PV. Objective The objective of this initi ... more
First Edition
This guideline provides advice in regards to applications for Marketing Authorisations for antimicrobial veterinary medicinal products (VMPs) on the data required and the methodology to be used for performing an assessment of the risk to public health from antimicrobial resistance (AMR) due to use o ... more
11 March 2021
Guidance for the preparation and submission of dossiers
First Edition
An overview of COVID-19 Vaccine AstraZeneca and why it is authorised in the EU. Available in 22 languages 18 Febr. 2021
Interim Assessement Report The EMA review was started by the Agency’s Committee for Medicinal Products for Human Use (CHMP) to support decision-making by health authorities. This first interim report includes information on seven experimental medicines ... more
First edition, November 1997 | Revised July 2002
PMPB/INS-GUIDE/01
Every day, fake medicines and medical products are sold at street corners, in open air markets or on unregulated websites in several countries in the African Region. These poor quality, unsafe medicines ... more
This Indicator-Based Pharmacovigilance Assessment Tool (IPAT) was developed as a comprehensive performance metric for pharmacovigilance and medicine safety systems.
The purpose of these guidelines is to help health workers to participate in the process of continuous surveillance of safety and efficacy of the pharmaceutical products which are used in clinical practice, thus help to achieve the ultimate goal to m ... more
The WHO Pharmaceuticals Newsletter provides you with the latest information on the safety of medicinal products and regulatory actions taken by authorities around the world. In addition, this edition includes summary and recommendations from the vi ... more
This handbook presents basic content and tips for implementing a school-based risk reduction programme. It is organised into five modules: its importance; approach and process; activities to benefit children up to five years old; activities for students aged 5–17; and activities for young people a ... more
In preparing this paper, the Pharmacovigilance Group of the Pan American Health Organization’s Pan American Network for Drug Regulatory Harmonization (PANDRH) adopted the perspective of PAHO/WHO, which considers Pharmacovigilance, an essential component of public health programs. Its intention was ... more
with recommended essential medicines for common diseases in patients in Stockholm County Council (Healthcare Region), Sweden