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Methods for the detection and characterisation of SARS-CoV-2 variants: second update, 21 June 2022

World Health Organization WHO, Regional Office of Europe (2022) C_WHO

This document aims to provide interim guidance for microbiology and virology experts, other laboratory professionals, laboratory managers, infectious disease programme managers, public health professionals and other stakeholders that provide primary, confirmatory or advanced testing for SARS-CoV-2, ... more

Buruli ulcer : diagnosis of Mycobacterium ulcerans disease : a manual for health care providers

F. Portaels; Johnson, P.; Meyers, W. World Health Organization WHO (2001) CC

This manual is to assist health care providers and laboratory scientists to diagnose mycobacterium ulcerans disease (Buruli ulcer). The manual aims to achieve a better understanding of the clinical presentation and its diagnosis. The methods described are tailored to various levels of care and avail... more

Buruli ulcer : management of Mycobacterium ulcerans disease : a manual for health care providers
recommended

J. Buntine; Crofts, K. World Health Organization WHO (2001) CC

This manual is addressed to health care providers dealing with Mycobacterium ulcerans disease (Buruli ulcer). The manual aims to achieve a better understanding of the disease, its clinical presentation and its surgical management. The manual is aimed particularly at district health care providers. A... more

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Case definitions, clinical classification, and disease phases Dengue, Chikungunya, and Zika
recommended

World Health Organisation (WHO) (2023) C_WHO

A person who lives in or has traveled in the previous 14 days to areas with dengue transmission, and presents with acute fever that has typically lasted 2 to 7 days, and two or more of the following clinical manifestations: nausea or vomiting, exanthema, headache or retro-orbital pain, myalgia or ar... more

Break COVID Now: The Gavi COVAX AMC Investment Opportunity

Gavi, the Vaccine Alliance (2022) CC

In April 2020, Gavi and COVAX joined the Access to COVID-19 Tools Accelerator (ACT-A) to provide equitable global access to COVID-19 vaccines to tackle the pandemic. In June 2020, the Gavi COVAX Advance Market Commitment (AMC) was launched to finance equitable access in 92 lower-income countries. Si... more

Case definitions, clinical classification, and disease phases

Pan American Health Organization PAHO (2023) C_WHO

The purpose of this document is to present concise information on the current case definitions for dengue, chikungunya, and Zika proposed by PAHO, as well as information on the clinical phases and severity classification of dengue and chikungunya.

Mpox Testing Strategy - November 2024

Africa Center for Disease Control and Prevention (2024) CC

Mpox is an emerging zoonotic disease caused by the mpox virus, a member of the Orthopoxvirus genus closely related to the variola virus that causes smallpox. Mpox was first discovered in 1958 when outbreaks of a pox-like disease occurred in monkeys kept for research. The first human case was recorde...d in 1970 in the Democratic Republic of the Congo (DRC) during a period of intensified effort to eliminate smallpox and since then the infection has been reported in a number of African countries. Mpox can spread in humans through close contact, usually skin-to-skin contact, including sexual contact, with an infected person or animal, as well as with materials contaminated with the virus such as clothing, beddings and towels, and respiratory droplets in prolonged face to face contact. People remain infectious from the onset of symptoms until all the lesions have scabbed and healed. The virus may spread from infected animals through handling infected meat or through bites or scratches. Diagnosis is confirmed by polymerase chain reaction (PCR) testing of material from a lesion for the virus’s DNA. Two separate clades of the mpox virus are currently circulating in Africa: Clade I, which includes subclades Ia and Ib, and Clade II, comprising subclades IIa and IIb. Clade Ia and Clade Ib have been associated with ongoing human-to-human transmission and are presently responsible for outbreaks in the Democratic Republic of the Congo (DRC), while Clade Ib is also contributing to outbreaks in Burundi and other countries. In 2022‒2023 mpox caused a global outbreak in over 110 countries, most of which had no previous history of the disease, primarily driven by human-to-human transmission of clade II through sexual contact. In just over a year, over 90,000 cases and 150 deaths were reported to the WHO. For the second time since 2022, mpox has been declared a global health emergency as the virus spreads rapidly across the African continent. On 13 Aug 2024, Africa CDC declared the ongoing mpox outbreak a Public Health Emergency of Continental Security (PHECS), marking the first such declaration by the agency since its inception in 2017.7 This declaration empowered the Africa CDC to lead and coordinate responses to the mpox outbreak across affected African countries. On August 14, 2024, the WHO declared the resurgence of mpox a Public Health Emergency of International Concern (PHEIC) emphasizing the need for coordinated international response. As of August 2024, Mpox has expanded beyond its traditional endemic regions, with new cases reported in countries including Sweden, Thailand, the Philippines, and Pakistan. Sweden has confirmed its first case of Clade 1 variant, which has been rapidly spreading in Africa, particularly in DRC. The emergence of this new variant raises concerns about its potential for higher lethality and transmission rates outside Africa. more

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Poliomyelitis

Centers for Disease Control and Prevention CDC (2011)

Pink Book's chapter

Nigeria: National Guideline for the Control and Management of Sickle Cell Disease

Federal Ministry of Health, Nigeria (2014) C1

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Polio Laboratory Manual

World Health Organization (2004) C_WHO

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The human qualities needed to complete the global eradication of polio

Dermot Maher World Health Organization (2013)

Bulletin of the World Health Organization Volume 91, Number 4, April 2013, 237-312

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Ethical issues in obstetrics and gynaecology by the FIGO committee for the Study of Ethical aspects of Human Reproduction and Woman's Health

FIGO (2012)

'Ethical Issues in Obstetrics and Gynecology' represents the results of carefully researched and considered discussion. The guidelines are intended to provide material for consideration and debate about ethical aspects of our discipline for member organisations and their constituent membership.

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Clinical Manifestations and Case Management of Ebola Haemorrhagic Fever Caused by a Newly Identified Virus Strain, Bundibugyo, Uganda, 2007–2008

Paul Roddy, Natasha Howard, Maria D. Van Kerkhove, et al. (2012) CC

PLoS ONE 7(12): e52986. doi:10.1371/journal.pone.0052986. Opern Access please download from the website

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A review of the available therapeutic agents that target the different steps of the ebola virus life cycle

Kang Yiu Lai, Wing Yiu George Ng and Fan Fanny Cheng (2014)

Medicinal products under development for the treatment of Ebola

European Medicines Agency EMA (2014)

Interim Assessement Report The EMA review was started by the Agency’s Committee for Medicinal Products for Human Use (CHMP) to support decision-making by health authorities. This first interim report includes information on seven experimental medicines intended for the treatment of people infecte... more

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Possible Sexual Transmission of Ebola Virus — Liberia, 2015

Centers for Disease Control and Prevention (2015)

Morbidity and Mortality Weekly Report (MMWR) Early Release Vol. 64 ; 1 May 2015

External Link

Surveillance strategy during Phase 3 of the Ebola response

World Health Organization (WHO) (2015) C_WHO

The goals of Ebola virus disease (EVD) surveillance during Phase 3 of the Ebola response are to promptly detect new, suspected EVD cases and deaths so as to trigger appropriate response, including rapid diagnosis, case isolation and management, contact tracing, safe burials, and the identification o... more

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Preliminary guidelines for the surveillance of microcephaly in newborns in settings with risk of Zika virus circulation

Pan American Health Organization PAHO; World Health Organization, Regional Office for the Americas (2016) C_WHO

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Briefing notes on Zika and Microcephaly

ReliefWeb (2016) C1

Source: World Health Organisation

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Zika virus PCR-standard

Nitsche, A. Robert-Koch-Institut (2016) CC

Update 19 May 2016

Buruli ulcer : management of Mycobacterium ulcerans disease : a manual for health care providers recommended

Case definitions, clinical classification, and disease phases Dengue, Chikungunya, and Zika recommended

Buruli ulcer : management of Mycobacterium ulcerans disease : a manual for health care providers
recommended

Case definitions, clinical classification, and disease phases Dengue, Chikungunya, and Zika
recommended