WHO has published the first-ever guidance on the clinical management of diphtheria. The only previously available guidance was an operational protocol. The new guidance followed the rigorous process for developing guidance at WHO.
It addresses the use of Diphtheria Antitoxin (DAT) in the treatmen...t of diphtheria. There is a worldwide shortage of DAT and evidence based recommendations on the use of DAT were requested by many Member States.
The guidance also includes new recommendations on antibiotics. In patients with suspected or confirmed diphtheria, WHO recommends using macrolide antibiotics (azithromycin, erythromycin) rather than penicillin antibiotics.
This clinical practice guideline has been rapidly developed recognizing the global increase in diphtheria outbreaks. Outbreaks of diphtheria in Nigeria, Guinea and neighbouring countries in 2023 have highlighted the urgent need for evidence-based clinical practice guidelines for the treatment of diphtheria. Given the sporadic nature of outbreaks, many clinicians in the affected regions have never managed acute diphtheria and its related complications. Diphtheria remains a neglected disease and vaccination is the top priority. At the same time, for patients with diphtheria, access to antibiotics, DAT and supportive care can be lifesaving.
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Vaksen DTaP (Difteri, Tetanòs, Koklich): Sa Ou Bezwen Konnen
Infographic/Map on Cholera and Diphteria cases in Yemen
SITUATION OVERVIEW as of 30 Jan.
- 688 000 refugees into Bangladesh (of which 585 000 in Kutupalong and Bulukhali camps)
- over 5000 clinically suspected Diphtheria cases and 37 deaths (reported in refugee camps)
Vaksen Td
Sa Ou Bezwen Konnen
As of 21 September, the diphtheria oubreak has resulted in a total of 453 deaths recorded among all confirmed cases (Case Fatality Rate/ CFR: 6.3%). A total of 11,587 suspected and 7,202 confirmed cases have been reported with 99 local government areas (LGAs) affected across 18 states. Event has be...en categorized as Grade 2 Emergency, requiring moderate 3 level coordinated support to the Government Response.
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This document provides detailed guidance on laboratory testing for suspected diphtheria cases during significant outbreaks or in low-resource settings. It aims to supplement and build on other existing WHO guidance documents on surveillance standards, diagnostics and research on Corynebacterium by p...roviding key considerations for laboratories that allow the rationalization and optimization of testing during outbreaks. The recommendations given here have been prepared by WHO in consultation with, and reviewed by, global experts with experience in laboratory analysis of Corynebacterium species and in outbreak settings, or with expertise in developing new technologies for diphtheria research and diagnosis. Unless otherwise stated, the considerations provided apply to diphtheria outbreaks caused by toxin-producing C. diphtheriae with a classical respiratory diphtheria presentation.
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Diphtherie gibt es auf der ganzen Welt. Früher starben bei Ausbrüchen dieser Infektionskrankheit viele Tausende Menschen, besonders Kinder. Weil die meisten Kinder in Europa geimpft sind, ist die Diphtherie hier seit den 1960er Jahren stark zurückgegangen. In Deutschland gab es lange Zeit nur noc...h Einzelfälle.
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To survive and thrive from early childhood through to adolescence and beyond, children need to be healthy. This enables them to access education so that every child in Ukraine, irrespective of background or circumstance, has an equal chance to fulfill their potential.
To ensure children thrive and ...remain in good health, the United Nations Children's Fund (UNICEF) has delivered to Ukraine 700,000 doses of tetanus-diphtheria (Td) vaccine to protect children after six and adults.
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Six maladies évitables par la vaccination ont été incluses dès le
début dans le PEV : la diphtérie, la rougeole, la coqueluche, la
poliomyélite, le tétanos et la tuberculose.
Large-Scale UN Response Needed to Address Health and Food Crises
This report is based on interviews with more than 150 health care professionals, Venezuelans seeking or in need of medical care who recently arrived in Colombia and Brazil, representatives from international and nongovernmental humani...tarian organizations. In addition, researchers analyzed data on the situation inside Venezuela from official sources, hospitals, international and national organizations, and civil society organizations.
We found a health system in utter collapse with increased levels of maternal and infant mortality; the spread of vaccine-preventable diseases, such as measles and diphtheria; and increases in numbers of infectious diseases such as malaria and tuberculosis (TB). Although the government stopped publishing official data on nutrition in 2007, research by Venezuelan organizations and universities documents high levels of food insecurity and child malnutrition, and available data shows high hospital admissions of malnourished children.
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3rd edition.
National immunization programme in Bangladesh has marched a long way to reach more than 7 million infants and pregnant mothers in each year. The goal of the immunization programme is to protect the individuals and public from vaccine preventable disease like Polio, Measles, Rubella, Di...phtheria, Tetanus, Hepatitis B, Whooping cough, Tuberculosis and Pneumonia
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Lancet Glob Health 2019 Published Online January 24, 2019 http://dx.doi.org/10.1016/S2214-109X(18)30479-0
The health-care system collapse underway in Venezuela is a cause of utmost concern for its people and, increasingly, for the wider region. Declines in provision of basic services, such as ...childhood immunisation, malaria control, water, sanitation, and nutritional support, have led to increasing morbidity and mortality rates from an array of preventable diseases, including malaria, measles, and diphtheria. Secondary and tertiary care have also been greatly affected, due to declining investment, out-migration of providers, and spiralling hyperinflation that has driven the country and its people into poverty.1 As is so often, and so tragically, the case, the most affected populations have been the most vulnerable: infants and children, their mothers, the poor (now the great majority of the populations), and indigenous people
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