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Therapeutics and COVID-19 (Living Guideline, 10 November 2023)

World Health Organization WHO (2023) C_WHO

WHO has updated its guidelines for COVID-19 therapeutics, with revised recommendations for patients with non-severe COVID-19. This is the 13th update to these guidelines. Updated risk rates for hospital admission in patients with non-severe COVID-19 The guidance includes updated risk rates for... hospital admission in patients with non-severe COVID-19. The current COVID-19 virus variants tend to cause less severe disease while immunity levels are higher due to vaccination, leading to lower risks of severe illness and death for most patients. This update includes new baseline risk estimates for hospital admission in patients with non-severe COVID-19. The new ‘moderate risk’ category now includes people previously considered to be high risk including older people and/or those with chronic conditions, disabilities, and comorbidities of chronic disease. The updated risk estimates will assist healthcare professionals to identify individuals at high, moderate or low risk of hospital admission, and to tailor treatment according to WHO guidelines: **High: **People who are immunosuppressed remain at higher risk if they contract COVID-19, with an estimated hospitalization rate of 6%. **Moderate: **People over 65 years old, those with conditions like obesity, diabetes and/or chronic conditions including chronic obstructive pulmonary disease, kidney or liver disease, cancer, people with disabilities and those with comorbidities of chronic disease are at moderate risk, with an estimated hospitalization rate of 3%. Low: Those who are not in the high or moderate risk categories are at low risk of hospitalization (0.5%). Most people are low risk. Review of COVID-19 treatments for people with non-severe COVID-19 WHO continues to strongly recommend nirmatrelvir-ritonavir (also known by its brand name ‘Paxlovid’) for people at high-risk and moderate risk of hospitalization. The recommendations state that nirmatrelvir-ritonavir is considered the best choice for most eligible patients, given its therapeutic benefits, ease of administration and fewer concerns about potential harms. Nirmatrelvir-ritonavir was first recommended by WHO in April 2022. If nirmatrelvir-ritonavir is not available to patients at high-risk of hospitalization, WHO suggests the use of molnupiravir or remdesivir instead. WHO suggests against the use of molnupiravir and remdesivir for patients at moderate risk, judging the potential harms to outweigh the limited benefits in patients at moderate risk of hospital admission. For people at low risk of hospitalization, WHO does not recommend any antiviral therapy. Symptoms like fever and pain can continue to be managed with analgesics like paracetamol. WHO also recommends against use of a new antiviral (VV116) for patients, except in clinical trials. The update also includes a strong recommendation against the use of ivermectin for patients with non-severe COVID-19. WHO continues to advise that in patients with severe or critical COVID-19, ivermectin should only be used in clinical trials. more

Guía para el cuidado de pacientes adultos críticos con COVID-19 en las Américas. Versión 3

Organización Panamericana de la Salud OPAS (2021) C_WHO

Este documento incluye los resultados de un proceso de elaboración rápida de guías. La información incluida en esta guía refleja la evidencia a la fecha publicada en el documento. Las recomendaciones se basaron en la evidencia disponible y su calidad (metodología GRADE) en el momento en que s... more

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Nurse practioner in critical care (Post Graduate-Residency Program)

Ministry of Health & Family Welfare ,India (2021) CC

Management of critical COVID-19: Acute hypoxaemic respiratory failure and COVID-19: Recognize ARDS
recommended

World Health Organization WHO (2022) C_WHO

WHO recommends prompt recognition of progressive acute hypoxaemic respiratory failure when a patient with respiratory distress is failing to respond to standard oxygen therapy and adequate preparation to provide advanced oxygen/ventilatory support. Hypoxaemic respiratory failure in ARDS commonly ... more

Competencies for critical care nurse specialist (Adult)

South African Nursing Council (2020) CC

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Steps Framework for Adult Critical Care Nurses.

Critical Care Networks - National Nurse Leads (2015) C1

tep 1 Competencies have been designed to provide staff with the core skills required to care for a critically ill patient safely, whilst under supervision. It is expected that Step 1 competencies will be completed prior to commencing an academic critical care programme. Steps 2 & 3 Competencies hav... more

Critical preparedness, readiness and response actions for COVID-19
recommended

World Health Organization WHO (2021) C_WHO

27 May 2021 All countries should increase their level of preparedness, alert and response to identify, manage and care for new cases of COVID-19. Countries should prepare to respond to different public health scenarios, recognizing that there is no one-size-fits-all approach to managing cases and o... more

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Management of critical COVID-19 Advanced non-invasive respiratory support: high-flow nasal oxygen and non-invasive ventilation- Part 2: NIPPV High-flow nasal oxygen (HFNO)
recommended

World Health Organization WHO (2022) C_WHO

For patients on HFNO with persistent hypoxaemia or respiratory distress: • Check the equipment: inspect the exterior of the machine, the tubing (circuit), the prong for any sign of mechanical damage, confirm it fits and the filters are in place. Ensure the settings are appropriate and flow is max... more

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Critical Care in Neurology

Kitchener – Hashem – Wahba – Khalaf – Zarif – Mansoor Flying Publisher (2012)

Essential critical care skills 1: what is critical care nursing?

Credland, N.; et al. (2021) C2

Nursing Times [online]; 117: 11, 18-21.

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A guide for caregivers of people with mental illness

MHFA MHFA (2009)

Mental illness can affect not only the life of the person with the illness, but also their close family, partners and friends. Significant people in a person’s life are often a source of support with the illness. However, family, partners and friends may be faced with a loved one’s men... more

The Critical Role of the Staff Nurse in Antimicrobial Stewardship—Unrecognized, but Already There

Olans R. N. , R. D. Olans, A. DeMaria Jr Clinical Infectious Diseases (2016) C2

An essential participant in antimicrobial stewardship who has been unrecognized and underutilized is the“staff nurse.”Although the role of staff nurses has not formally been recognized in guidelines for implementing and operating antimicrobial stewardship programs (ASPs) or defined in the medica... more

Emergency Illnesses and Major Injuries Affecting Infants and Children; Including Adolescent Girls Who Are Pregnant

Maternal & Childhealth Advocacy International MCAI (2021) C1

Handbook 1

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Guidelines for the clinical management of severe illness from influenza virus infections

World Health Organization WHO (2022) C_WHO

Management of critical COVID-19 Advanced non-invasive respiratory support: high-flow nasal oxygen and non-invasive ventilation- Part 1: Characteristics of NIV
recommended

World Health Organization WHO (2022) C_WHO

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Management of critical COVID-19 Advanced non-invasive respiratory support: high-flow nasal oxygen and non-invasive ventilation -Part 3: NIPPV (CPAP and BiPAP)
recommended

World Health Organization WHO (2022) C_WHO

For patients on NIPPV or HFNO with persistent hypoxaemia or respiratory distress: • Check the equipment: inspect the exterior of the machine, the tubing (circuit), the mask for any sign of mechanical damage, confirm it fits securely without leak (if CPAP/BiPAP) and the filters are in place. Ensur... more

Guidelines on Clinical management of severe acute respiratory illness (SARI) in suspect/confirmed novel coronavirus (nCoV) cases

National Centre for Disease Control (formerly National Institute of Communicable Diseases) National Centre for Disease Control (formerly National Institute of Communicable Diseases) (2020) C2

Accessed: 16.04.2020

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Caregiving and Experiences of Health, Illness and Coping in the Context of Paediatric and Adolescent HIV and Poverty

A. G. Lentoor Web of Science; INTECH (2018) C2

We are IntechOpen, the world’s leading publisher of Open Access books Built by scientists, for scientists Selection of our books indexed in the Book Citation Index in Web of ScienceTM Core Collection (BKCI) http://dx.doi.org/10.5772/intechopen.68759

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Crisis Management of Critical Incidents

Pete Buth, European Interagency Security Forum (EISF) (2010) C2

This EISF Briefing Paper seeks to outline the requirements of crisis management structures, providing a general guideline of crisis management planning, Crisis Management Teams (CMTs) and post-crisis follow-up. It is followed by the May 2010 EISF Briefing Paper, Abduction Management, that will focu... more

Community Case Management Essentials: Treating Common Childhood Illnesses in the Community

David Marsh, Ashley Aakesson, Kechi Anah et al. CORE Group; Save the Children; BASICS; MCHIP (2012)

2nd edition. Known as “Community Case Management of Sick Children” (CCM), this approach sends community-based health workers out to find, diagnose, and successfully treat sick children, in partnership with their families. Inspired by the classic “Immunization Essentials”, this guide methodic... more

Management of critical COVID-19: Acute hypoxaemic respiratory failure and COVID-19: Recognize ARDS recommended

Critical preparedness, readiness and response actions for COVID-19 recommended

Management of critical COVID-19 Advanced non-invasive respiratory support: high-flow nasal oxygen and non-invasive ventilation- Part 2: NIPPV High-flow nasal oxygen (HFNO) recommended

Management of critical COVID-19 Advanced non-invasive respiratory support: high-flow nasal oxygen and non-invasive ventilation- Part 1: Characteristics of NIV recommended

Management of critical COVID-19 Advanced non-invasive respiratory support: high-flow nasal oxygen and non-invasive ventilation -Part 3: NIPPV (CPAP and BiPAP) recommended

Management of critical COVID-19: Acute hypoxaemic respiratory failure and COVID-19: Recognize ARDS
recommended

Critical preparedness, readiness and response actions for COVID-19
recommended

Management of critical COVID-19 Advanced non-invasive respiratory support: high-flow nasal oxygen and non-invasive ventilation- Part 2: NIPPV High-flow nasal oxygen (HFNO)
recommended

Management of critical COVID-19 Advanced non-invasive respiratory support: high-flow nasal oxygen and non-invasive ventilation- Part 1: Characteristics of NIV
recommended

Management of critical COVID-19 Advanced non-invasive respiratory support: high-flow nasal oxygen and non-invasive ventilation -Part 3: NIPPV (CPAP and BiPAP)
recommended