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1
Interim emergency guidelines
The report presents current information (updated to September 2015) on candidate vaccines, therapies and medical devices for Ebola and gives an overview of completed and on-going trials.
Interim Guidance.
A number of medical problems have been reported in survivors, including mental health issues. Ebola virus may persist in some body fluids, including semen. Ebola survivors need comprehensive support for the medical and psychosocial challenges they face and also to minimize the ... more
WHO has published the first-ever guidance on the clinical management of diphtheria. The only previously available guidance was an operational protocol. The new guidance followed the rigorous process for developing guidance at WHO. It addresses th ... more
Journal of the ASEAN Federation of Endocrine Societies ; Vol.27 No.1 May 2012 ; Page 34-39
Document No. : FDA/SMC/CTD/GL-CCT/2013/01
The use of Delamanid and Bedaquiline for Children with Drug-Resistant Tuberculosis.

Controlled clinical trails in Tuberculosis

A. Jindani, A. Nunn, D. A. Enarson International Union Against Tuberculosis and Lung Disease (2004)
A Guide For Multicentre Trials in High-Burden Countries
Introduction Chapter A.3
Introduction Chapter A.4 2017 edition
Introduction Chapter A.5
Miscellaneous Chapter J.8
The purpose of the Clinical Practice Guideline for Treatment of Patients with Anxiety Disorders in Primary Care is to provide professionals with practical recommendations based on scientific evidence to assist in the detection and effective treatmen ... more
Provides clinical descriptions, diagnostic guidelines, and codes for all mental and behavioural disorders commonly encountered in clinical psychiatry. The book was developed from chapter V of the Te ... more

Mental Health Promotion. Case Studies from Countries

Shekhar Saxena and Preston J. Garri World Federation for Mental Health; World Health Organization WHO (2004) C_WHO
Petersenet al.International Journal of Mental Health Systems2011,5:8http://www.ijmhs.com/content/5/1/8
Accessed: 29.09.2019
Supplement Article www.jaids.com J Acquir Immune Defic Syndr  Volume 78, Supplement 1, August 15, 2018
Solidarity” is an international clinical trial to help find an effective treatment for COVID-19, launched by the World Health Organization and partners. The Solidarity Trial will compare four treatment options against standard of care, to asses ... more
Updated July 3, 2020
In the Region of the Americas, the leishmaniases are a group of diseases caused by various species of Leishmania, which cause a set of clinical syndromes in infected humans that can involve the skin, mucosa, and visceral organs. The spectrum of ... more
WHO has developed a clinical case definition of post COVID-19 condition by Delphi methodology that includes 12 domains, available for use in all settings. This first version was developed by patients, researchers and others, representing all WHO reg ... more
Interim rapid response guidance, 10 June 2022. It includes considerations for certain populations such as patients with mild disease with considerations for community care, patients with moderate to severe disease, sexually active persons, pregnant or breastfeeding women, children and young persons ... more
Update, 23 de junio de 2022
Diabetes mellitus is a major cause of morbidity and mortality in Scotland and worldwide, with an increasing prevalence. In 2009 there were around 228,000 people registered as having diabetes in Scotland, an increase of 3.6% from the preceding year. This increase relates, in part, to the increasing a ... more
HIV/AIDS Programme
The case for evidence- based communication of science
BMJ Open Science 2021;5:e100202. doi:10.1136/ bmjos-2021-100202
This curriculum can be used freely in order to stimulate means of ethical analysis, reflection and decision-making.
This handbook was designed primarily as a tool for district clinical specialist teams (DCSTs), and for the provincial specialists who will guide and support their work. This handbook will also be useful to managers of health facilities, heads of ... more
The 2014–2015 Ebola epidemic in western Africa was the longest and most deadly Ebola epidemic in history, resulting in 28,616 cases and 11,310 deaths in Guinea, Liberia, and Sierra Leone. The Ebola virus has been known since 1976, when two separate outbreaks were identified in the Democratic Repub ... more
Online interactive electronic ICF-based Documentation Tool. To facilitate the use of ICF Core Sets, a manual outlining one approach for using them in clinical practice was published in 2012, including an accompanying electronic documentation tool ww ... more
The clinical guidelines and protocols for the practice of emergency medicine presented in this document are designed to be a useful resource not only for those wishing to become emergency medicine specialists, but also for general practitioners and ... more
BMJ 2009; 338 doi: https://doi.org/10.1136/bmj.b158 (Published 05 February 2009) Cite this as: BMJ 2009;338:b158 Correspondence to: A Burns alistair.burns@manchester.ac.uk
The current document is anupdate of the guidelines developed by the EUCAST subcommittee on detection of resistance mechanisms. The EUCAST Steering Committee has carried out the current update. The document has been developed mainly for routine use in clini ... more
The latest on the COVID-19 global situation & long term sequelae, March 2021
Evidence-based guidelines are one of the most useful tools for improving public health and clinical practice. Their purpose is to formulate interventions based on strong evidence of efficacy, avoid unnecessary risks, use resources efficiently, reduc ... more
Pathogens . 2021 Nov 16;10(11):1493.doi: 10.3390/pathogens10111493 .Chronic manifestations of Chagas disease present as disabling and life-threatening condi-tions affecting mainly the cardiovascular and gastrointestinal systems. Although meaningful research has outlined the different molecular mech ... more
Human schistosomiasis, a parasitic and often chronic illness, is one of the major neglected tropical diseases worldwide. It is estimated that 240 million people suffer from schistosomiasis, with more than 200000 fatalities recorded each year. Schistosomiasis is caused by an infection of the blood fl ... more
Background: The World Health Organization (WHO) published a clinical case definition of post COVID-19 condition, by a Delphi consensus, on 6 October 2021. That process concluded that a separate definition may be applicable for children. It is impo ... more
The 2023 meeting of the WHO Clinical Consortium on Healthy Ageing (CCHA) was the group’s ninth gathering and took place in Geneva 5–7 December 2023. The meeting was structured around seven panels, with a series of technical presentations, plenar ... more

Guidelines for Clinical and Operational Management of Drug-Resistant Tuberculosis

José A. Caminero International Union Against Tuberculosis and Lung Disease (The Union) (2013)
This Review summarizes many of the persistent biological alterations associated with childhood maltreatment including changes in neuroendocrine and neurotransmitter systems and pro-inflammatory cytokines in addition to specific alterations in brain areas associated with mood regulation. Finally, I d ... more
Of the 50 antibiotics in the pipeline, 32 target WHO priority pathogens but the majority have only limited benefits when compared to existing antibiotics. Two of these are active against the multi-drug resistant Gram-negative bacteria, which are spreading rapidly and require urgent solutions. Gr ... more

Guide for HIV/AIDS Clinical Care

Susa Coffey,et al. AECT; HRSA; US Dept.Health; et al. (2014) C1
Version 10.1_5 October 2020 These Guidelines are available in different formats: As a paper booklet, a PDF, a mobile app, and now also as a website. The 2019 version of the Guidelines introduces a new drug-drug interaction panel and now consists of six main sections, including a general overview ... more
Article published in: Journal of Intensive Care (2015) 3:16
Guidelines for Good Clinical Laboratory Practices (GCLP) outlines the principles and procedures to be followed by medical laboratories involved in clinical research and/or patient care so as to prov ... more
This new guideline on non-clinical interventions to reduce unnecessary caesarean sections incorporates the views, fears and beliefs of both women and health professionals about caesarean sections. It also considers the complex dynamics and limitatio ... more
Epilepsia, 55(4):475–482, 2014 doi: 10.1111/epi.12550
Treat 3 Million by 2005 WHO/HIV/2005.02 African Region
Accessed: 11.03.2020

Guidelines on Clinical Management of COVID – 19

Government of India Ministry of Health & Family Welfare Directorate General of Health Services (EMR Division) Government of India Ministry of Health & Family Welfare Directorate General of Health Services (EMR Division) (2020) C2
17th March 2020
Accessed: 16.04.2020
A thesis submitted for the Degree of Master of Theology at the South African Theological Seminary
The Zambia Population Based HIV impact assessment of 2016, reported the prevalence of viral hepatitis in Zambia as ranging between 5.6% among adults aged 15 to 59% in the general population, and 7.1% among HIV infected individuals. It is estimated that the majority of persons with chronic hepatitis ... more
The World Health Organization invites clinicians and patients to collect information on COVID-19 in a systematic way and contribute clinical data to the WHO Clinical Platform to expand our knowledge ... more
Med Princ Pract 2021;30:17–28 An overview of ethics and clinical ethics is presented in this review. The 4 main ethical principles, that is beneficence, nonmaleficence, autonomy, and justice, are defined and explained. Informed consent, ... more

National Contraception Clinical Guidelines 2019

Department of Health National Department of Health South Africa (2019) CC
The Department of Health (DOH) has developed a National Integrated Sexual and Reproductive Health and Rights (SRHR) Policy.1 This policy addresses the many cross-cutting issues relating to SRH service provision, drawing together the principles, rights, and guidance for planning and implementation th ... more
This report presents an analysis of antibacterial agents in preclinical (third annual review) and clinical (fifth annual review) development. The analysis covers traditional (direct-acting small molecules) and non-traditional antibacterial agents in ... more
For health care providers. Sub-Saharan Africa has the highest maternal mortality in the world. According to estimates by the United Nations Maternal Mortality Estimation Inter-Agency Group (UN MMEIG)1 in September 2017, while the African Region had recorded a significant decline in maternal mortali ... more
The socioeconomic factors and public health inadequacies that facilitated the rapid spread of this infection continue to exist. As it is a new and emerging disease it has not received sufficient coverage yet in the medical curricula of Member States. Specific treatment is not available, and there is ... more
Research and Reports in Tropical Medicine 2022:13 25–40. Chagas disease (CD) is caused by the parasite Trypanosoma cruzi, and it is endemic in Central, South America, Mexico and the South of the United States. It is an important cause of early mortality and morbidity, and it is associated with po ... more
Plos Neglected Tropical Diseases 8(11): e3229 (20 November 2014)
The present booklet is about gender-responsive substance abuse treatment services for women. It is part of the United Nations Office on Drugs and Crime (UNODC) project to develop tools to support the development and improvement of substance abuse treatment services, based on evidence from the litera ... more
Supplement Article J Acquir Immune Defic Syndr  Volume 78, Supplement 1, August 15, 2018 www.jaids.com
Review Article: Journal of Nutritional Health & Food Science Vitamin Deficiency and Tuberculosis: Need for Urgent Clinical Page 1- 6
This research aims to identify a core set of clinical skills for working in a Community Based Rehabilitation (CBR) setting, and to discuss whether they are appropriate for task shifting to a new or an alternative cadre of rehabilitation workers.
World J Meta-Anal. Aug 26, 2017; 5(4): 103-123 Published online Aug 26, 2017. doi: 10.13105/wjma.v5.i4.103

Epilepsy - A manual for Medical and Clinical Officers in Africa

International League Against Epilepsy; World Health Organization; International Bureau for Epilepsy (2002) C_WHO
Research Article Received: August 21, 2017; Accepted: August 29, 2017; Published: Spetember 05, 2017 This article is available in: http://www.imedpub.com/advanced-techniques-in-clinical-microbiology/

Introduction to HIV, AIDS and STI Surveillance - HIV Clinical Staging and Case Reporting

United States Department of Health and Human Services; Centers for Disease Control and Prevention (HHS-CDC); Global AIDS Program (GAP); et al. United States Department of Health and Human Services; Centers for Disease Control and Prevention (HHS-CDC); Global AIDS Program (GAP); et al. (2009) C2
Participant Manual September 2009
Technical Update HIV Treatment July 2017